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DEVINSKY, O; EMOTO, S; PORTER, RJ; THEODORE, WH; NADI, NS
"CEREBROSPINAL-FLUID BIOCHEMICAL CORRELATES OF BEHAVIOR IN PARTIAL EPILEPSY"
Journal of epilepsy 1991 FEB ; 4(2):81-85
We correlated interictal (> 6 h after seizure) cerebrospinal fluid (CSF) levels of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), neuropeptides, amino acids, and cortisol with self-report behavioral rating scales in 19 patients with medically intractable complex partial seizures. The Beck Depression Inventory, Spielberger Trait Anxiety Scale, and Personality Disorders Questionnaire-Revised [DSM-IIIR-based personality disorder (PD) rating scale] were used to assess behavior. There were no significant correlations between either HVA or 5-HIAA and behavioral scores. The strongest findings were the positive correlations between CSF levels of neuropeptide Y and depression and between CSF levels of cortisol and antisocial PD. Five other significant correlations were also found. There was no significant effect of the presence or levels of carbamazepine or phenytoin on those CSF neurochemicals that were associated with behavioral scores. This preliminary study suggests that certain behavioral features in epilepsy may have neurochemical markers

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# 104314 (ISI:A1991GX78900004)


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