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Kuzniecky, R; Hetherington, H; Ho, S; Pan, J; Martin, R; Gilliam, F; Hugg, J; Faught, E
"Topiramate increases cerebral GABA in healthy humans"
Neurology 1998 Aug; 51(2):627-629
Topiramate (TOP) is a novel anticonvulsant drug with multiple mechanisms of action used in the treatment of epilepsy. Measurements of cerebral GABA were obtained in six controls using 1H MRS at baseline and at 3 and 6 hours following the administration of 3 mg/kg of TOP. Brain GABA concentrations rose by 72% at 3 hours and by 64% at 6 hours compared with baseline (p < 0.004). This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals

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