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Wheless, JW; Vazquez, BR; Kanner, AM; Ramsay, RE; Morton, L; Pellock, JM
"Rapid infusion with valproate sodium is well tolerated in patients with epilepsy"
Neurology 2004 OCT 26 ; 63(8):1507-1508
Many IV antiepileptic drugs administered in emergency situations to patients with prolonged seizures have serious adverse effects. For this reason, the authors conducted a multicenter, open-label, prospective, dose-escalation study of IV valproate sodium administered to patients with epilepsy at rates of infusion of up to 6 mg/kg/minute and doses of up to 30 mg/kg. Valproate sodium had no clinically significant negative effects on blood pressure and pulse rate and caused only mild-to-moderate, reversible adverse events

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