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ASSOCIATION BETWEEN FOOD INSUFFICIENCY AND MORTALITY: JOINT EFFECT WITH INCOME ON ALL-CAUSE AND CAUSE-SPECIFIC MORTALITY [Meeting Abstract]

Zhu, Jennifer; Parikh, Ankit; Lipsitz, Stuart R; Natarajan, Sundar
ISI:000209142900068
ISSN: 1525-1497
CID: 2782352

CYSTATIN C-BASED GLOMERULAR FILTRATION RATE: AN IMPROVED PREDICTOR OF MORTALITY [Meeting Abstract]

Milin, Alexandra; Parikh, Ankit; Lipsitz, Stuart R; Natarajan, Sundar
ISI:000209142900129
ISSN: 1525-1497
CID: 2782322

Iron Deficiency in Community-Dwelling US Adults With Self-Reported Heart Failure in the National Health and Nutrition Examination Survey III: Prevalence and Associations With Anemia and Inflammation

Parikh, Ankit; Natarajan, Sundar; Lipsitz, Stuart R; Katz, Stuart D
Background- Iron deficiency has been proposed as a potential therapeutic target in heart failure, but its prevalence and association with anemia and clinical outcomes in community-dwelling adults with heart failure have not been well characterized. Methods and Results- Using data from the Third National Health and Nutrition Examination Survey, we evaluated the associations between iron deficiency, hemoglobin, C-reactive protein (CRP), and all-cause and cardiovascular mortality in 574 adults with self-reported heart failure. Iron deficiency was defined in both absolute and functional terms as a ferritin level <100 mug/L or between 100 and 299 mug/L if the transferrin saturation was <20%. Iron deficiency was present in 61.3% of participants and was associated with reduced mean hemoglobin (13.6 versus 14.2 g/dL, P=0.007) and increased mean CRP (0.95 versus 0.63 mg/dL, P=0.04). Over a median of 6.7 years of follow-up, there were 300 all-cause deaths, 193 of which were from cardiovascular causes. In age- and sex-adjusted Cox proportional hazards models, hemoglobin, CRP, and transferrin saturation but not iron deficiency were significantly associated with all-cause and cardiovascular mortality. In multivariate models, hemoglobin remained an independent predictor of cardiovascular mortality, whereas CRP remained an independent predictor of both all-cause and cardiovascular mortality. Conclusions- Iron deficiency is common in heart failure and is associated with decreased hemoglobin and increased CRP. In multivariate analysis, hemoglobin was associated with cardiovascular mortality while CRP was associated with both all-cause and cardiovascular mortality. Iron deficiency was not associated with all-cause or cardiovascular mortality in this cohort
PMCID:3180903
PMID: 21705484
ISSN: 1941-3297
CID: 137836

Prevalence of Functional Iron Deficiency in Adults With Heart Failure and Associations With Anemia, Inflammation, and Mortality [Meeting Abstract]

Parikh, Ankit D.; Natarajan, Sundar; Lipsitz, Stuart R.; Katz, Stuart D.
ISI:000281501800249
ISSN: 1071-9164
CID: 114013

Association Between a DASH-Like Diet and Mortality in Adults With Hypertension: Findings From a Population-Based Follow-Up Study

Parikh, Ankit; Lipsitz, Stuart R; Natarajan, Sundar
BackgroundAlthough the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP) in hypertensive adults, its effect on mortality is unclear.MethodsThis prospective cohort study evaluated the association between diet and mortality in 5,532 hypertensive adults in the Third National Health and Nutrition Examination Survey. Hypertension was determined by self-report, medication use, or BP measurement. Diet was ascertained by 24-h dietary recall using nine nutrient targets. The primary outcome was all-cause mortality. Secondary outcomes included specific causes of mortality (cardiovascular disease (CVD), ischemic heart disease (IHD), stroke, and cancer).ResultsOf the 5,532 participants, 391 (7.1%) consumed a DASH-like diet. During an average of 8.2 person-years of follow-up, there were 1,537 all-cause deaths; this included 312 cancer deaths and 788 cardiovascular deaths, of which 447 were due to IHD and 142 were due to stroke. After adjusting for multiple confounders while accounting for the complex survey design by utilizing survey weights, strata, and clusters in Cox proportional hazards models, a DASH-like diet was associated with lower mortality from all causes (hazard ratio (HR) 0.69, 95% confidence interval (CI) 0.52-0.92, P = 0.01) and stroke (HR 0.11, 95% CI 0.03-0.47, P = 0.003). Mortality risk from CVD (HR 0.92, 95% CI 0.63-1.35, P = 0.67), IHD (HR 0.77, 95% CI 0.47-1.24, P = 0.28), and cancer (HR 0.51, 95% CI 0.23-1.10, P = 0.09) did not reach statistical significance.ConclusionsThough findings for specific causes of mortality are mixed, consumption of a DASH-like diet is associated with lower all-cause mortality in adults with hypertension.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.10American Journal of Hypertension 2009; doi:10.1038/ajh.2009.10
PMID: 19197247
ISSN: 0895-7061
CID: 96811