Try a new search

Format these results:

Searched for:

person:baa300

in-biosketch:true

Total Results:

4


Carotid Body Tumor in Review

DeSilva, Sean; Adelson, Brandon; Vinodkumar, Velayudhan
ORIGINAL:0015723
ISSN: 2638-521x
CID: 5286062

Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease

Dionne, S; Calderon, M R; White, J H; Memari, B; Elimrani, I; Adelson, B; Piccirillo, C; Seidman, E G
Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene expression and its downstream function. We hypothesized that the hormonal form of vD (1,25D) could beneficially modulate innate immune function in CD. Using peripheral mononuclear cells and monocyte-derived dendritic cells (Mo-DCs) from CD, it was found that 1,25D decreased Toll-like receptor (TLR)-induced cytokine production and enhanced cytokine levels induced by muramyl dipeptide (MDP), the NOD2 ligand. 1,25D increased the synergistic effect provided by NOD2 and TLR co-activation on interleukin (IL)-10, IL-23, and tumor necrosis factor-alpha (TNF-α). Whereas 1,25D inhibits Mo-DC TLR-induced cytokines, co-stimulation of NOD2 results in increased IL-10 and IL-23. IL-12p70 was completely abrogated by 1,25D. 1,25D similarly modulated cytokine production by immune cells in ulcerative colitis patients and healthy controls. Mo-DCs from CD patients heterozygous for NOD2 mutations had a response similar to those from patients without NOD2 mutations. Immune cells from patients homozygous for the 1007 fs mutation were unresponsive to MDP and 1,25D. Our in vitro data support 1,25D as a potential modulator of immunity. However, these results cannot be extrapolated to CD patients without further controlled studies.
PMID: 24781050
ISSN: 1935-3456
CID: 5286052

Prevalence of Crohn's Disease in Patients With Spondyloarthropathies: Interim Analysis of the SPaCE study [Meeting Abstract]

Kopylov, Uri; Starr, Michael; Watts, Craig; Adelson, Brandon A.; Seidman, Ernest G.
ISI:000322997202300
ISSN: 0016-5085
CID: 5264422

Influence of NOD2 Genotype on the Modulatory Effect of Vitamin D on NOD2 and TLR- Induced Cytokine Responses in Crohn's Disease [Meeting Abstract]

Dionne, Serge; Adelson, Brandon A.; Piccirillo, Ciriaco; Bitton, Alain; Seidman, Ernest G.
ISI:000322997200022
ISSN: 0016-5085
CID: 5264432