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Vitamin D Deficiency in a Young, Atopic Pediatric Population [Meeting Abstract]

Bantz, Selene K.; Dy, Tiffany; Herzog, Ronit
ISI:000361129600480
ISSN: 0091-6749
CID: 3799632

The Role of Vitamin D in Pediatric Asthma

Bantz, Selene K; Zhu, Zhou; Zheng, Tao
The detrimental effects of vitamin D deficiency in pediatrics have become increasingly apparent and extend beyond skeletal health. Unfortunately, vitamin D deficiency is highly prevalent in atopic pediatric patients, in whom it may disrupt the immune system and induce significant worsening of reactive airways. This review presents evidence that lung development and immune regulatory functions are vitamin D-dependent. We also review clinical studies that explore how vitamin D supplementation may prevent respiratory infections and help improve asthma control, and we elaborate how these effects may vary among populations. We reveal the strong need of screening measures for vitamin D deficiency in high risk pediatric populations, particularly African-Americans, Hispanic-Americans, and children with obesity. Finally, we emphasize that all children, especially those who are asthmatic, should be assessed to ensure adequate intake or supplementation with at least the minimum recommended doses of vitamin D. The simple intervention of vitamin D supplementation may provide significant clinical improvement in atopic disease, especially asthma.
PMCID:4415725
PMID: 25938135
ISSN: 2373-9312
CID: 3799622

The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma

Bantz, Selene K; Zhu, Zhou; Zheng, Tao
The development of atopic dermatitis (AD) in infancy and subsequent allergic rhinitis and asthma in later childhood is known as the atopic march. This progressive atopy is dependent on various underlying factors such as the presence of filaggrin mutations as well as the time of onset and severity of AD. Clinical manifestations vary among individuals. Previously it was thought that atopic disorders may be unrelated with sequential development. Recent studies support the idea of a causal link between AD and later onset atopic disorders. These studies suggest that a dysfunctional skin barrier serves as a site for allergic sensitization to antigens and colonization of bacterial super antigens. This induces systemic Th2 immunity that predisposes patients to allergic nasal responses and promotes airway hyper reactivity. While AD often starts early in life and is a chronic condition, new research signifies that there may be an optimal window of time in which targeting the skin barrier with therapeutic interventions may prevent subsequent atopic disorders. In this review we highlight recent studies describing factors important in the development of atopic disorders and new insights in our understanding of the pathogenesis of the atopic march.
PMCID:4240310
PMID: 25419479
ISSN: 2155-9899
CID: 3799612

Successful Treatment of Refractory Cholinergic Urticaria with Omalizumab in a Pediatric Patient [Meeting Abstract]

Bantz, Selene K.; Calderon, Jose G.; Dreyfus, David H.
ISI:000316550800105
ISSN: 0091-6749
CID: 3799642