Faculty Bibliography

Case Description: Patient with history of HIV, who presented with two weeks of progressive right lower extremity sensory loss and left hemiparesis. Exam was consistent with Brown-Sequard Syndrome (BSS) with left upper and lower extremity weakness, impaired pinprick sensation throughout right lower extremity, and decreased temperature sensation throughout right upper and lower extremity.
Setting(s): Hospital Inpatient Unit Patient: 50-year-old male with Brown-Sequard Syndrome (BSS). Assessment/Results: MRI cervical spine revealed focal nodular enhancement at the left C5-C6 spinal cord with associated extensive cord signal changes and expansion from C2-T1. Labs were notable for elevated inflammatory markers, elevated angiotensin-converting enzyme (ACE) and CSF protein. Chest CTwas significant for mediastinal and left perihilar lymphadenopathy. Bronchoscopy revealed endobronchial studding and non-caseating granulomas most consistent with sarcoidosis. He was started on methylprednisolone for spinal neurosarcoidosis with improvement in strength.
Discussion(s): Sarcoidosis is a multiorgan system disease characterized by noncaseating granulomas. Sarcoidosis involving the spinal cord (spinal neurosarcoidosis) is rare. Moreover, the diagnosis of spinal neurosarcoidosis is challenging due to its significant variability in clinical findings and lack of definitive laboratory or imaging characteristics. In patients with HIV the diagnosis might be even more difficult since there are numerous HIV-associated pathogenic processes that can lead to spinal cord dysfunction. Research on the coexistence of HIV and sarcoidosis has also shown that sarcoidosis can develop during the restoration of Tcell immunity associated with antiretroviral therapy (Immune Reconstitution Inflammatory Syndrome). This phenomenon as well as the diagnostic challenges highlights the importance of considering neurosarcoidosis in the differential of patients with myelopathy, especially patients with HIV.
Conclusion(s):We report an unusual case of neurosarcoidosis presenting as BSS in a patient with HIV. Although neurosarcoidosis is rare, this case underscores the importance of considering this diagnosis in patients presenting with myelopathy and its significance in patients with concurrent HIV

BACKGROUND/OBJECTIVE: To document receipt of certain understudied preventive services and health behaviors in spinal cord injury (SCI) and to compare them to the general adult population. METHODS: Cross-sectional survey. PARTICIPANTS: One hundred ninety-nine community-living adults with SCI residing in New Jersey. MAIN OUTCOME MEASURES: Receipt of recommended general preventive health services, such as screening for colorectal and prostate cancer and dental examinations, and health-related behaviors, including injury prevention, obesity, and tobacco use, as assessed by survey items in the Behavioral Risk Factors Surveillance System. RESULTS: Deficiencies in provision of needed preventive services were evident but were similar to those noted in the general adult population. Among participants 50 years of age or older, 47% had not had either a stool test for occult blood in the last year or a sigmoidoscopy/colonoscopy in the last 5 years. While 43.9% of participants were overweight or obese and 46.3% of these were trying to lose weight, only 1 3.8% had been counseled to lose weight. Twenty-two percent smoked on at least some days. Safety problems were evident: 15.5% did not use seatbelts consistently; 44% had not discussed a fire escape plan at home; and smoke detectors were often not checked adequately. Twelve and a half percent of participants reported having injuries during the last year, and fully 75% of these were related to SCI. Emergency room use and hospitalization were frequent. Participants had a median of 3 to 5 current doctors. CONCLUSIONS: Persons with SCI need the general screening and safety services recommended for all persons. Enhanced efforts will be needed to meet national goals in Healthy People 2010 in SCI

OBJECTIVES: Health literacy has been related to indicators of health outcomes in a number of populations, but not in spinal cord injury (SCI). The current study aimed to describe levels of health literacy in SCI and to investigate its possible associations with morbidity, health-related quality of life, functional independence, community participation, and life satisfaction. DESIGN: Cross-sectional survey of 107 community-living people with SCI recruited in a New Jersey outpatient SCI center. Primary measures were the Test of Functional Health Literacy in Adults (TOFHLA), standard questions about morbidity from the Behavioral Risk Factors Surveillance Study, the Craig Handicap Assessment and Reporting Technique (CHART), Short Form-12 (SF-12), and Diener's Satisfaction with Life Scale. RESULTS: Health literacy was marginal or inadequate (TOFHLA = 0-74) in only 14% of the sample. TOFHLA scores correlated significantly with physical health morbidity, even after control for severity of motor paralysis and education. American Spinal Injury Association (ASIA) Motor Scores were correlated with physical morbidity and CHART Physical Independence scores; and education was related to community Mobility, Occupation, and Economic Independence, and Satisfaction with Life scores, independent of other factors. Rasch analysis identified ceiling measurement limitations in the TOFHLA. CONCLUSIONS: Health literacy levels in this sample were higher than those found in other groups. Health literacy was independently related to physical health morbidity, but its associations with other outcomes were limited, entwined with education, and affected by severity of injury. Future research might examine higher-level aspects of health literacy to overcome ceiling measurement problems. Mediators of the association between health literacy and morbidity, such as health self-care behaviors, should also be examined

OBJECTIVES: To examine relationships between level of disability and receipt of certain preventive health services, including demographic and systems variables that may explain or confound these relationships. DESIGN: Analysis of recent (1998 and 2000) data from the Behavioral Risk Factor Surveillance System, a nationwide telephone survey. SETTING: States reporting data on disability (13 in 1998, 18 in 2000). PARTICIPANTS: Noninstitutionalized persons living in the community. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Frequency of receipt of recommended preventive health services, including colorectal, cervical, and breast cancer screening, and influenza and pneumococcal vaccination. An ordinal index of disability severity was constructed from questions on activity limitations. RESULTS: In 2000, people with mild and moderate disability received influenza and pneumonia vaccinations somewhat more frequently than people without disabilities, but people with the most severe disabilities least frequently received vaccinations that year. Disabled women received fewer Papanicolaou tests and clinical breast examinations, but significant differences did not occur for mammograms in 2000. Fewer differences as a function of disability level were apparent in 2000 than 1998. Demographic variables affected receipt of most preventive services. Access to routine checkups affected all preventive services independent of disability level in both years. CONCLUSIONS: Severity of disability is related to receipt of certain preventive services but not necessarily in a simple or unidirectional way. Regardless of disability, receipt of a checkup was an important determinant of receipt of preventive health services. For almost all services and groups studied, preventive care remained below targeted goals for Healthy People 2010

As the use of marijuana among adolescents remains high, more effective interventions are needed. We conducted this cross-sectional survey at an outpatient, university-based, adolescent clinic to determine the prevalence of marijuana use in an inner-city adolescent population and to examine the relationship of stress and coping methods to marijuana user status (never user, experimenter, and frequent user). The subjects were 918 adolescents aged 12-21 years. Lifetime use in this population was 59% (n = 611) with 18.4% (n = 191) reporting frequent weekly use. Almost all (97%) marijuana users acknowledged marijuana use by friends. Stepwise logistic regression analysis showed that negative life events, greater use of the negative coping method of anger and less frequent use of the positive coping method of parental support were significantly and independently related to marijuana user status. In the presence of high peer use, exploring parent-child relationships and use of anger coping and intervening accordingly may decrease marijuana use