Faculty Bibliography
Searched for:
person:donovv01
in-biosketch:true
Total Results:
32
Cancer prevention research (Philadelphia, Pa.). 2022:15(2):87-100.DOI: 10.1158/1940-6207.CAPR-21-0242
Dietary Pterostilbene for MTA1-Targeted Interception in High-Risk Premalignant Prostate Cancer
Prostate cancer remains one of the most prevalent cancers in aging men. Active surveillance subpopulation of patients with prostate cancer includes men with varying cancer risk categories of precancerous disease due to prostatic intraepithelial neoplasia (PIN) heterogeneity. Identifying molecular alterations associated with PIN can provide preventable measures through finding novel pharmacologic targets for cancer interception. Targeted nutritional interception may prove to be the most appropriate chemoprevention for intermediate- and high-risk active surveillance patients. Here, we have generated two prostate-specific transgenic mouse models, one overexpressing MTA1 (R26MTA1
PMID: 34675064
ISSN: 1940-6215
CID: 5152912
Peripheral blood morphologic and laboratory predictors of death in hospitalized COVID-19 patients [Meeting Abstract]
Background: Numerous predictors of poor outcome in COVID-19 patients have been identified, including alterations in the composition of leukocytes in the peripheral blood. There nonetheless remains a need to improve predictions of patient outcomes following hospitalization in order to appropriately triage patients. We addressed this question by evaluating hematologic parameters and peripheral blood smear morphology in patients who either died or recovered following hospitalization.
Design(s): The study groups included 48 patients who died following admission ("cases") and 48 age-matched controls who recovered ("controls"). Laboratory values were collected for PCR-positive COVID-19 hospitalized patients at two time points: T1- the time of admission, and T2 - the time of discharge/death. Peripheral blood smears from two-time points for patients who died were analyzed independently by 4 pathologists.
Result(s): Study patient demographic details are shown in Table 1. Anemia and thrombocytopenia were present at the time of admission in both groups, and there was a significant decline in hemoglobin and RBC count between T1 and T2; PLT counts decreased, but not in a statistically significant manner (Table 2). WBC and absolute neutrophils increased following admission specifically in patients who died of disease (Table 2). No statistically significant differences were observed in all other hematologic parameters evaluated. Blood from patients who died showed pseudo Pelger-Huet changes 60.41% (n=29), toxic granulations 8.3% (n=4), atypical lymphocytes 91% (n=44), and giant platelets 94% (n=45) with immature myeloid forms increasing at T2. In contrast to patients who recovered , patients who died showed increased D-dimer values at admission; D-dimer values did not correlate with the presence of thrombocytopenia.
Conclusion(s): Hospitalized COVID-19 patients who died showed: 1) elevated D-dimer levels at admission; and 2) increasing WBC and neutrophil counts during their hospitalization. While several morphologic changes were observed in the blood in those who subsequently died, the changes observed were not specific to COVID-19; however, the presence of immature myeloid precursors in hospitalized patients was associated with subsequent neutrophilia and death. This finding suggests that in addition to closely monitoring the two laboratory parameters describe above, special care should be taken to asses blood films for the presence of immature myeloid precursors. Additional studies will be required to validate these findings in a larger group of hospitalized patients (Figure Presented)
Design(s): The study groups included 48 patients who died following admission ("cases") and 48 age-matched controls who recovered ("controls"). Laboratory values were collected for PCR-positive COVID-19 hospitalized patients at two time points: T1- the time of admission, and T2 - the time of discharge/death. Peripheral blood smears from two-time points for patients who died were analyzed independently by 4 pathologists.
Result(s): Study patient demographic details are shown in Table 1. Anemia and thrombocytopenia were present at the time of admission in both groups, and there was a significant decline in hemoglobin and RBC count between T1 and T2; PLT counts decreased, but not in a statistically significant manner (Table 2). WBC and absolute neutrophils increased following admission specifically in patients who died of disease (Table 2). No statistically significant differences were observed in all other hematologic parameters evaluated. Blood from patients who died showed pseudo Pelger-Huet changes 60.41% (n=29), toxic granulations 8.3% (n=4), atypical lymphocytes 91% (n=44), and giant platelets 94% (n=45) with immature myeloid forms increasing at T2. In contrast to patients who recovered , patients who died showed increased D-dimer values at admission; D-dimer values did not correlate with the presence of thrombocytopenia.
Conclusion(s): Hospitalized COVID-19 patients who died showed: 1) elevated D-dimer levels at admission; and 2) increasing WBC and neutrophil counts during their hospitalization. While several morphologic changes were observed in the blood in those who subsequently died, the changes observed were not specific to COVID-19; however, the presence of immature myeloid precursors in hospitalized patients was associated with subsequent neutrophilia and death. This finding suggests that in addition to closely monitoring the two laboratory parameters describe above, special care should be taken to asses blood films for the presence of immature myeloid precursors. Additional studies will be required to validate these findings in a larger group of hospitalized patients (Figure Presented)
EMBASE:634717280
ISSN: 1530-0307
CID: 4857082
Sporadic Burkitt Lymphoma Presenting with Middle Cranial Fossa Masses with Sphenoid Bony Invasion and Acute Pancreatitis in a Child [Case Report]
Acute pancreatitis in children is usually due to infection, trauma, or anatomical abnormalities and is rarely due to obstruction from malignancy. Sporadic Burkitt lymphoma (BL) is an aggressive non-Hodgkin B-cell lymphoma that usually involves the bowel or pelvis, with isolated cases presenting as acute pancreatitis. We report a case of BL in a 12-year-old male presenting as acute pancreatitis with obstructive jaundice and a right middle cranial fossa mass invading the sphenoid bone. The common bile duct in this case was dilated to 21 mm in diameter on abdominal ultrasound and to 26 mm on magnetic resonance cholangiopancreatography (MRCP), significantly greater than any value reported in the literature for BL. Given the rapidly progressing nature of BL, we emphasize the importance of recognizing heterogeneous presentations of this disease to improve patient survival. We also conclude that it is important to consider malignancy in a child with acute pancreatitis, particularly in the presence of obstructive jaundice or multisystem involvement. Other Presentations. This case report has no prior publications apart from the abstract being accepted to the 2020 SIOP (International Society of Pediatric Oncology) meeting and 2020 ASPHO conference (canceled due to the COVID-19 pandemic) and subsequently published as an abstract only in Pediatric Blood and Cancer. We have also presented the abstract as a poster presentation at our institution's (NYU Langone Hospital-Long Island, previously known as NYU Winthrop) annual research day conference in 2020.
PMCID:8457982
PMID: 34567815
ISSN: 2090-6706
CID: 5026952
Broad ligament Extraintestinal Gastrointestinal Stromal Tumor (EGIST): Case report and brief overview of EGIST [Case Report]
•Highly suspicious pelvic mass may require preoperative biopsy for diagnosis.•Neoadjuvant imatinib lowers EGIST tumor burden in extensive disease preoperatively.•EGIST resection aims at complete surgical resection and negative margins.•This case was managed with complete surgical resection and adjuvant imatinib.•Prognostic factors in EGIST are size, mitosis, location and genetic mutations.
PMCID:7452469
PMID: 32885016
ISSN: 2352-5789
CID: 4629762
Grape Powder Supplementation Attenuates Prostate Neoplasia Associated with Pten Haploinsufficiency in Mice Fed High-Fat Diet
SCOPE/METHODS:Previous studies have identified potent anticancer activities of polyphenols in preventing prostate cancer. The aim of the current study is to evaluate the chemopreventive potential of grape powder (GP) supplemented diets in genetically predisposed and obesity-provoked prostate cancer. METHODS AND RESULTS/RESULTS:mice. There are no significant changes in body weight and food intake in GP supplemented diet groups. CONCLUSIONS:GP diet supplementation can be a beneficial chemopreventive strategy for obesity-related inflammation and prostate cancer progression. Monitoring serum miRNAs can facilitate the non-invasive evaluation of chemoprevention efficacy.
PMID: 32618118
ISSN: 1613-4133
CID: 4546272
Sporadic Burkitt Lymphoma Presenting With Sphenoid Bone Invasion and Acute Pancreatitis in a Child [Meeting Abstract]
ISI:000581769201402
ISSN: 1545-5009
CID: 4696302
Novel prostate cancer mouse models for testing targeted chemopreventive potential of pterostilbene [Meeting Abstract]
ISI:000590059303394
ISSN: 0008-5472
CID: 4821072
Can grape powder supplemented diet prevent prostate cancer progression [Meeting Abstract]
ISI:000590059305196
ISSN: 0008-5472
CID: 4821082
Necrotizing Myositis: A Rare Necrotizing Soft Tissue Infection Involving Muscle
INTRODUCTION/BACKGROUND:Necrotizing myositis (NM) is an extremely rare necrotizing soft tissue infection involving muscle. Unlike similar infections (eg, necrotizing fasciitis, clostridial myonecrosis) that can be more readily diagnosed, NM can have a benign presentation then rapidly progress into a life-threatening condition with a mortality rate of 100% without surgical intervention. CASE REPORT/METHODS:A 74-year-old man with a history of prostate cancer with radiation therapy, seed implants, and 2 transurethral resection procedures presented to the emergency department after a fall. He was initially diagnosed and treated for urosepsis. Sixteen hours after presentation, he complained of pain and swelling of his right groin. Computed tomography of the abdomen and pelvis showed gas findings suspicious for necrotizing infection of the bilateral thighs. Surgical exploration revealed NM. Separate cultures from the left thigh and bladder grew Streptococcus intermedius, Clostridium clostridioforme, and Peptostreptococcus, suggesting a possible common source of infection from the prostate gland or the osteomyelitic pubic symphysis, which subsequently spread to the bilateral thighs. CONCLUSIONS:To the best of the authors' knowledge, this is the first reported case of S intermedius and C clostridioforme causing NM. A high index of suspicion is required for extremely rare conditions like NM, because early diagnosis and surgical intervention significantly reduce mortality.
PMID: 30561371
ISSN: 1943-2704
CID: 3693592
High-grade myelodysplastic syndrome with a rare variant t(3;8)(q26.2;q24.1) translocation involving mecom (EVI1) and MYC gene rearrangement [Meeting Abstract]
A 72-year-old man presented with weakness, lightheadedness, and weight loss. He had an episode of loss of consciousness 7 days prior to his presentation. Physical exam showed pallor and splenomegaly. Laboratory evaluation revealed anemia and leukopenia. A peripheral blood smear revealed hypochromic red blood cells with dacrocytes and few schistocytes. A bone marrow biopsy was performed and was hypercellular, with a relative increase in blasts. Megakaryocytes were mildly increased and showed dysplastic features. Mature erythroid and myeloid elements were present in decreased numbers. Flow cytometry showed 16% myeloid blasts. The gated population was positive for CD11C, CD13, CD33, CD34, CD38, and CD117 and partially positive for cytoplasmic myeloperoxidase. The combined immunophenotypic and morphologic analysis was consistent with a high-grade MDS of the MDS-EB2 (previously RAEB-2) type. Cytogenetic and FISH analyses revealed monosomy 7, as well as a t(3;8) rearrangement with a MYC-EVI1 rearrangement. The patient showed poor response to treatment and remained transfusion dependent. Following recurrent hospitalizations and no improvement, he declined further treatment and elected to receive home hospice care. MYC, a transcription factor located on chromosome 8q24.1, is involved in the expression regulation of 15% of human genes. EVI1, located on chromosome 3q26.2, is a transcription factor essential for regulation of self-renewal of hematopoietic stem cells and is one of the dominant oncogenes associated with myeloid leukemia. MYC rearrangements are a rare event in myeloid neoplasms, and the EVI1-MYC fusion has not yet been described to our knowledge. Both genes, when involved in hematologic malignancies, are associated with poor response to treatment and worse prognosis. This translocation may represent a small subset of cases with an aggressive clinical course, possibly requiring early identification, personalized treatment, and close follow-up
EMBASE:629440931
ISSN: 1943-7722
CID: 4231082
