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Multidetector CT appearance of leiomyosarcoma of the splenic vein

Niver, B E; Megibow, A J; Faust, M J; Rosenkrantz, A B
PMID: 21356533
ISSN: 1365-229x
CID: 133460

CT of jejunal diverticulitis: imaging findings, differential diagnosis, and clinical management [Case Report]

Macari, M; Faust, M; Liang, H; Pachter, H L
AIM: To describe the imaging findings of jejunal diverticulitis as depicted at contrast-enhanced computed tomography (CT) and review the differential diagnosis and clinical management. MATERIALS AND METHODS: CT and pathology databases were searched for the diagnosis of jejunal diverticulitis. Three cases were identified and the imaging and clinical findings correlated. RESULTS: Jejunal diverticulitis presents as a focal inflammatory mass involving the proximal small bowel. A trial of medical management with antibiotics may be attempted. Surgical resection may be required if medical management is unsuccessful. CONCLUSION: The imaging findings at MDCT may allow a specific diagnosis of jejunal diverticulitis to be considered and may affect the clinical management of the patient
PMID: 17145267
ISSN: 0009-9260
CID: 70314

Treatment of gastrointestinal cytomegalovirus infection with twice-daily foscarnet: a pilot study of safety, efficacy, and pharmacokinetics in patients with AIDS

Dieterich DT; Poles MA; Lew EA; Martin-Munley S; Johnson J; Nix D; Faust MJ
Ten patients with AIDS and cytomegalovirus (CMV) gastrointestinal infection were included in an open-label study to evaluate the safety, efficacy, and pharmacokinetics of 90 mg of intravenous foscarnet/kg of body weight twice daily accompanied by (pre)hydration of 500 to 750 ml. Efficacy was documented endoscopically, while safety was evaluated clinically by patient reports and physical and laboratory observation. The pharmacokinetics of foscarnet was evaluated after the first dose and following approximately 20 days of therapy. Nine patients (90%) responded histopathologically, nine (90%) responded endoscopically, and nine (90%) responded symptomatically to foscarnet therapy. Adverse events resulted in discontinuance of medication in the case of one patient. The mean maximal concentration was 621 microM following the first dose and 687 microM at steady state (P = 0.11). The apparent elimination rate constant and elimination half-life were not different between dose 1 and steady state. There were no significant changes in foscarnet excretion or renal clearance between dose 1 and steady state. The steady-state volume of distribution was 23.4 liters following the first dose and 19.0 liters at steady state (P < 0.002). Twice-daily foscarnet appeared to be safe and efficacious in the treatment of CMV gastrointestinal disease in this study, resulting in endoscopic or histologic improvement in 9 of the 10 (90%) patients. Minor changes in clearance and volume of distribution noted at steady state compared to single-dose administration are readily explained by study design, known information about foscarnet pharmacokinetics, and changes in body weight and creatinine clearance in the patients
PMCID:163891
PMID: 9174175
ISSN: 0066-4804
CID: 7140

ENDOSCOPY IN AIDS PATIENTS RESULTS OF 645 PROCEDURES [Meeting Abstract]

Dieterich, D; Lim, B; Nieves, S; Wand, A; Dolitsky, D; Gorovets, A; Faust, M
ISI:A1989U089700175
ISSN: 0016-5107
CID: 31696

EFLORNITHINE (DFMO) TREATMENT OF CRYPTOSPORIDIOSIS IN AIDS PATIENTS [Meeting Abstract]

DIETERICH, DT; CHACHOUA, A; FAUST, MJ; MOSES, M
ISI:A1986D933400130
ISSN: 0002-9270
CID: 41360

SUCCESSFUL TREATMENT OF CYTOMEGALOVIRUS GASTROINTESTINAL INFECTIONS IN AIDS PATIENTS WITH 9-(1,3-DIHYDROXY-2-PROPOXY-METHYL) GUANINE [Meeting Abstract]

DIETERICH, DT; CHACHOUA, A; FAUST, MJ; MOSES, M
ISI:A1986D933400131
ISSN: 0002-9270
CID: 41361

DIFLUOROMETHYLORNITHINE TREATMENT OF CRY [Meeting Abstract]

DIETERICH, DT; CHACHOUA, A; FAUST, M
ISI:A1986A921200303
ISSN: 0016-5085
CID: 41453

"TREATMENT OF CYTOMEGALOVIRUS GASTROINTESTINAL INFECTIONS IN AIDS PATIENTS WITH 9-(1,3-DIHYDROXY-2-PROPOXY-METHYL) GUANINE" [Meeting Abstract]

DIETERICH, DT; CHACHOUA, A; FAUST, M; MOSES, M
ISI:A1986A921200305
ISSN: 0016-5085
CID: 41454

DISSEMINATED KAPOSIS SARCOMA - INVOLVEMENT OF THE GI TRACT AMONG A GROUP OF HOMOSEXUAL MEN [Meeting Abstract]

Stern, JO; Dieterich, D; Faust, M; Laubenstein, L; Horowitz, L
ISI:A1982NK72200736
ISSN: 0016-5085
CID: 30417