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Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of neurologic sequelae in patients with post-acute sequelae of SARS-CoV-2 infection (PASC)

Melamed, Esther; Rydberg, Leslie; Ambrose, Anne Felicia; Bhavaraju-Sanka, Ratna; Fine, Jeffrey S; Fleming, Talya K; Herman, Eric; Phipps Johnson, Jamie L; Kucera, Jennifer Ryan; Longo, Michele; Niehaus, William; Oleson, Christina V; Sampsel, Sarah; Silver, Julie K; Smith, Martha M; Verduzco-Gutierrez, Monica
PMID: 36989078
ISSN: 1934-1563
CID: 5502612

Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

Bonilla, Hector; Peluso, Michael J; Rodgers, Kathleen; Aberg, Judith A; Patterson, Thomas F; Tamburro, Robert; Baizer, Lawrence; Goldman, Jason D; Rouphael, Nadine; Deitchman, Amelia; Fine, Jeffrey; Fontelo, Paul; Kim, Arthur Y; Shaw, Gwendolyn; Stratford, Jeran; Ceger, Patricia; Costantine, Maged M; Fisher, Liza; O'Brien, Lisa; Maughan, Christine; Quigley, John G; Gabbay, Vilma; Mohandas, Sindhu; Williams, David; McComsey, Grace A
Although most individuals recover from acute SARS-CoV-2 infection, a significant number continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the unexplained symptoms that are frequently referred to as long COVID, which could last for weeks, months, or even years after the acute phase of illness. The National Institutes of Health is currently funding large multi-center research programs as part of its Researching COVID to Enhance Recover (RECOVER) initiative to understand why some individuals do not recover fully from COVID-19. Several ongoing pathobiology studies have provided clues to potential mechanisms contributing to this condition. These include persistence of SARS-CoV-2 antigen and/or genetic material, immune dysregulation, reactivation of other latent viral infections, microvascular dysfunction, and gut dysbiosis, among others. Although our understanding of the causes of long COVID remains incomplete, these early pathophysiologic studies suggest biological pathways that could be targeted in therapeutic trials that aim to ameliorate symptoms. Repurposed medicines and novel therapeutics deserve formal testing in clinical trial settings prior to adoption. While we endorse clinical trials, especially those that prioritize inclusion of the diverse populations most affected by COVID-19 and long COVID, we discourage off-label experimentation in uncontrolled and/or unsupervised settings. Here, we review ongoing, planned, and potential future therapeutic interventions for long COVID based on the current understanding of the pathobiological processes underlying this condition. We focus on clinical, pharmacological, and feasibility data, with the goal of informing future interventional research studies.
PMCID:10034329
PMID: 36969241
ISSN: 1664-3224
CID: 5449152

Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of cognitive symptoms in patients with post-acute sequelae of SARS-CoV-2 infection (PASC)

Fine, Jeffrey S; Ambrose, Anne Felicia; Didehbani, Nyaz; Fleming, Talya K; Glashan, Lissette; Longo, Michele; Merlino, Alexandra; Ng, Rowena; Nora, Gerald J; Rolin, Summer; Silver, Julie K; Terzic, Carmen M; Verduzco-Gutierrez, Monica; Sampsel, Sarah
PMID: 34902226
ISSN: 1934-1563
CID: 5138292

Barriers to discharge from inpatient rehabilitation: a teamwork approach

Cruz, Lisanne Catherine; Fine, Jeffrey S; Nori, Subhadra
Purpose In order to prevent adverse events during the discharge process, coordinating appropriate community resources, medication reconciliation, and patient education needs to be implemented before the patient leaves the hospital. This coordination requires communication and effective teamwork amongst staff members. In order to address these concerns, the purpose of this paper is to incorporate the TeamSTEPPS principles to develop a discharge plan that would best meet the needs of the patients as they return to the community. Design/methodology/approach Through a gap analysis, barriers to discharge were identified from the following disciplines: nursing, social work, physical and occupational therapy, psychology, and rehabilitation physician. To improve communication, weekly meetings and twice-weekly huddles were implemented so that concerns regarding discharge obstacles could be identified and resolved. Visibility of discharge dates were improved by use of graduation certificates in patient rooms and green ribbons on patient wheelchairs. Findings After implementation of this discharge intervention, length of stay was reduced providing cost savings to the hospital, patient satisfaction on HCAHP surveys improved and demonstrated patient satisfaction with the discharge process, and readmission rates improved. Originality/value This study demonstrated that effective teamwork and communication can improve patient safety and satisfaction during the discharge period.
PMID: 28256931
ISSN: 0952-6862
CID: 2758432

Quadriceps tears and tendon ruptures

Chapter by: Lichtenstein, Ann H; Fine, Jeffery
in: Musculoskeletal sports and spine disorders : a comprehensive guide by Kahn, Stuart; Xu, Rachel Yinfei (Eds)
Cham, Switzerland : Springer, [2017]
pp. 277-279
ISBN: 9783319505121
CID: 3654042

Plantar fasciitis

Chapter by: Adamov, Elizabeth; Fine, Jeffery
in: Musculoskeletal sports and spine disorders : a comprehensive guide by Kahn, Stuart; Xu, Rachel Yinfei (Eds)
Cham, Switzerland : Springer, [2017]
pp. 299-303
ISBN: 9783319505121
CID: 3654082

Ischial tuberosity bursitis

Chapter by: Walker-McCarter, Fairen; Fine, Jeffery
in: Musculoskeletal sports and spine disorders : a comprehensive guide by Kahn, Stuart; Xu, Rachel Yinfei (Eds)
Cham, Switzerland : Springer, [2017]
pp. 225-226
ISBN: 9783319505121
CID: 3654012

Mallet finger and Jersey finger

Chapter by: Walker-McCarter, Fairen; Fine, Jeffery
in: Musculoskeletal sports and spine disorders : a comprehensive guide by Kahn, Stuart; Xu, Rachel Yinfei (Eds)
Cham, Switzerland : Springer, [2017]
pp. 149-152
ISBN: 9783319505121
CID: 3653952

Patient safety at handoff in rehabilitation medicine

Siefferman, Jason W; Lin, Emerald; Fine, Jeffrey S
The Joint Commission Center for Transforming Healthcare has cited communication as the most frequent root cause in sentinel events, with failed patient handoffs playing a "role in an estimated 80% of serious preventable adverse events." Handoff, or transfer of patient care information, occurs formally and informally many times each day, within and between care teams, across all levels of care providers and between institutions. Handoff at rehabilitation admission is at a particularly high risk for communication failure, potentially affecting patient safety. This review of the patient handoff literature discusses the importance of safe handoff, the information to be included, barriers to handoff, and improvement methodologies.
PMID: 22537691
ISSN: 1047-9651
CID: 549132

Lower extremity weakness after childbirth: a case of preserved nerve conduction studies, axonal involvement, and good recovery [Case Report]

Nutini, Dennis N; Fine, Jeffrey S
PMID: 22269458
ISSN: 1934-1563
CID: 2758422