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Ten-Week-Old Girl With Lethargy, Weakness, and Poor Feeding

Diprisco, Bridget E; Chhabria, Sasha; Forem, Sandra L; Rosenberg, Rebecca E
PMID: 23117238
ISSN: 0009-9228
CID: 212232

Asthma and epilepsy: are they related? A retrospective study

Castaneda GY; Heilbroner PL; Shah N; Forem S; Fish I
Numerous studies have suggested that epilepsy and asthma may be related conditions. There has, however, been little epidemiologic data published to support this association. We conducted a retrospective study to determine whether the prevalence of epilepsy is increased among children with asthma, and the prevalence of asthma is increased among children with epilepsy, in comparison with the general pediatric population. We reviewed the medical records, at a large city hospital, of two groups of pediatric outpatients: (1) 400 consecutive patients with asthma followed regularly at the asthma and allergy clinic; and (2) 201 consecutive patients with idiopathic epilepsy followed regularly at the pediatric neurology clinic. Patients with a history of birth prior to 36 weeks' gestational age were excluded. Among the 400 cases of asthma, there were three patients with idiopathic epilepsy (prevalence of 0.75%). The prevalence of epilepsy was similar in mild (0.79%) and moderate-to-severe (0.73%) asthma. Among the 201 cases of idiopathic epilepsy, there were 12 patients with asthma (prevalence of 5.97%). Similar percentages of epilepsy patients with and without asthma reported generalized tonic-clonic, complex partial, simple partial, and myoclonic seizures as their predominant type. The prevalence values in this study are consistent with the prevalence of epilepsy and asthma in the general pediatric population. Our findings therefore suggest that idiopathic epilepsy and asthma are not etiologically related or mutually predisposing conditions. Small samples, failure to exclude patients born prematurely, and the equation of electroencephalographic (EEG) abnormalities with epilepsy may account for the results of previous studies
PMID: 9660512
ISSN: 0883-0738
CID: 7526

Congenital pontocerebellar atrophy in three patients: clinical, radiologic and etiologic considerations [Case Report]

Zelnik N; Dobyns WB; Forem SL; Kolodny EH
We report three patients with severe pontocerebellar atrophy (PCA) associated with a variable degree of cerebral atrophy. The clinical features consisted of progressive microcephaly, central hypotonia, visual impairment, abnormal eye movements and delayed psychomotor development. These are similar but not identical to the features of pontocerebellar hypoplasia type 2 described by Barth. The picture also differs from the classical form of autosomal dominant olivopontocerebellar atrophy. While in two patients the disease seemed to be genetic with highly suspicious autosomal recessive inheritance, the etiology in the third patient was probably nongenetic. We suggest that PCA is a morphologic entity with distinct radiologic features but variable clinical, pathophysiologic and etiologic backgrounds
PMID: 8912329
ISSN: 0028-3940
CID: 12525

A case of 2-methyl, 3-hydroxy butyryl-CoA dehydrogenase deficiency [Meeting Abstract]

Sansaricq, C; Heilbroner, P; Snyderman, SE; Fish, I; Forem, S
ISI:A1996VC68900153
ISSN: 0364-5134
CID: 2095442

Use of a calcium channel blocker (nicardipine HCl) in the treatment of childhood moyamoya disease [Case Report]

Hosain SA; Hughes JT; Forem SL; Wisoff J; Fish I
Moyamoya disease is a cerebrovascular disease characterized radiologically by progressive narrowing and occlusion of the arteries contributing to the circle of Willis and its branches. There is formation of an exuberant collateral network of blood vessels at the base of the brain, which is thought to arise in response to chronic ischemia. Clinically, the course is variable, with patients having repeated transient ischemic attacks, strokes, migraine, and seizures. Effective treatment is not available. The etiology and pathophysiology of moyamoya disease are largely unknown. Two patients with arteriographically proven moyamoya disease were identified. Both patients were symptomatic before age 5 years. Despite successful encephaloduroarteriosynangiosis revascularization procedures, they continued to experience an inexorable downhill course. A calcium channel blocker (nicardipine HCl) was introduced in order to prevent further symptoms. After the introduction of nicardipine, no further strokes occurred in either patient. There were no further episodes of transient ischemic attacks, seizures, or headache in one patient and decreased frequency in the other. In patients with moyamoya disease, nicardipine may have a beneficial effect on cerebral hemodynamics and may prevent ischemic sequelae by optimizing existing collateral circulation
PMID: 7822727
ISSN: 0883-0738
CID: 56655

Selective dorsal rhizotomy: outcome and complications in treating spastic cerebral palsy

Abbott R; Johann-Murphy M; Shiminski-Maher T; Quartermain D; Forem SL; Gold JT; Epstein FJ
Selective dorsal rhizotomy has shown great promise as a treatment for the functional disabilities and deforming hypertonia of spastic cerebral palsy. At New York University Medical Center, 200 children underwent this procedure between 1986 and 1990. All groups, whether walkers, crawlers, or nonlocomotors, showed improvement in the tone and range of most muscles tested. Half of these patients experienced complications. Thirty-five of these were serious and included bronchospasm (5.5%), aspiration pneumonia (3.5%), urinary retention (7%), and sensory loss (2%). There are, however, clear indications that warn of these complications; monitoring and prophylactic treatment can minimize their effects, and the possibility of such problems is more than offset by the proven benefits of this operative procedure
PMID: 8264882
ISSN: 0148-396x
CID: 56491

THREE CASES OF NEUROCYSTICERCOSIS IN NEW YORK CITY IN AMERICAN BORN JEWISH CHILDREN [Meeting Abstract]

Persaud, D; Munoz, J; Gesner, M; Forem, S; Schantz, P
ORIGINAL:0011105
ISSN: 0031-3998
CID: 2095452

Selective posterior rhizotomy for the treatment of spasticity: a review [see comments] [Comment]

Abbott R; Forem SL; Johann M
The use of sensory rhizotomy has long been used for the treatment of spasticity. This review outlines the historical development of this treatment, the current surgical technique, and its physiologic rationale. Patient selection, postoperative treatment, and complications are also discussed
PMID: 2692811
ISSN: 0256-7040
CID: 10401

SELECTIVE POSTERIOR RHIZOTOMY FOR THE TREATMENT OF SPASTICITY - SHORT-TERM OUTCOME [Meeting Abstract]

ABBOTT, R; FOREM, S; JOHANN, M; EPSTEIN, F; WISOFF, J; GRANT, A
ISI:A1988N700800064
ISSN: 0256-7040
CID: 570512