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Widefield multimodal imaging of presumed bilateral diffuse uveal melanocytic proliferation

Ramtohul, Prithvi; Sebrow, Dov; Freund, K Bailey
PMID: 38387860
ISSN: 1715-3360
CID: 5634502

Silicone Oil From Syringes-A Potentially Overlooked Issue for Intravitreal Injections-Reply

Bijon, Jacques; Freund, K Bailey
PMID: 38175624
ISSN: 2168-6173
CID: 5628372

FROM DRUSEN TO TYPE 3 MACULAR NEOVASCULARIZATION

Bousquet, Elodie; Santina, Ahmad; Corradetti, Giulia; Sacconi, Riccardo; Ramtohul, Prithvi; Bijon, Jacques; Somisetty, Swathi; Voichanski, Shilo; Querques, Giuseppe; Sadda, SriniVas; Freund, K Bailey; Sarraf, David
PURPOSE/OBJECTIVE:To investigate the imaging features preceding the occurrence of type 3 (T3) macular neovascularization (MNV) using tracked spectral-domain optical coherence tomography. METHOD/METHODS:From a cohort of eyes with T3 MNV and ≥ 12 months of previously tracked spectral-domain optical coherence tomography, T3 lesions that developed above soft drusen were selected for optical coherence tomography analysis. Retinal imaging findings at the location where type T3 MNV occurred were analyzed at each follow-up until the onset of T3 MNV. The following optical coherence tomography parameters were assessed: drusen size (height and width), outer nuclear layer/Henle fiber layer thickness at the drusen apex, and the presence of intraretinal hyperreflective foci, retinal pigment epithelium disruption, incomplete retinal pigment epithelium and outer retina atrophy, and complete retinal pigment epithelium and outer retina atrophy. RESULTS:From a cohort of 31 eyes with T3 MNV, T3 lesions developed above soft drusen in 20 eyes (64.5%). Drusen showed progressive growth ( P < 0.001) associated with outer nuclear layer/Henle fiber ( P < 0.001) thinning before T3 MNV. The following optical coherence tomography features were identified preceding the occurrence of T3 MNV, typically at the apex of the drusenoid lesion: disruption of the external limiting membrane/ellipsoid zone and/or the retinal pigment epithelium, hyperreflective foci, and incomplete retinal pigment epithelium and outer retina atrophy/complete retinal pigment epithelium and outer retina atrophy. CONCLUSION/CONCLUSIONS:The results demonstrate specific anatomic alterations preceding the occurrence of T3 MNV that most commonly originates above soft drusen. Drusen growth, reduced outer nuclear layer/Henle fiber thickness, and retinal pigment epithelium atrophy at the drusen apex precede the development of T3 MNV. Identifying these optical coherence tomography features should warrant close monitoring for identification of T3 MNV, which can benefit from prompt intravitreal anti-vascular endothelial growth factor therapy.
PMID: 37756671
ISSN: 1539-2864
CID: 5624252

Papillorenal syndrome with extensive retinoschisis

Ramtohul, Prithvi; Bijon, Jacques; Freund, K Bailey
PMID: 37770011
ISSN: 1715-3360
CID: 5627862

Central serous chorioretinopathy: An evidence-based treatment guideline

Feenstra, Helena M A; van Dijk, Elon H C; Cheung, Chui Ming Gemmy; Ohno-Matsui, Kyoko; Lai, Timothy Y Y; Koizumi, Hideki; Larsen, Michael; Querques, Giuseppe; Downes, Susan M; Yzer, Suzanne; Breazzano, Mark P; Subhi, Yousif; Tadayoni, Ramin; Priglinger, Siegfried G; Pauleikhoff, Laurenz J B; Lange, Clemens A K; Loewenstein, Anat; Diederen, Roselie M H; Schlingemann, Reinier O; Hoyng, Carel B; Chhablani, Jay K; Holz, Frank G; Sivaprasad, Sobha; Lotery, Andrew J; Yannuzzi, Lawrence A; Freund, K Bailey; Boon, Camiel J F
Central serous chorioretinopathy (CSC) is a relatively common disease that causes vision loss due to macular subretinal fluid leakage and is often associated with reduced vision-related quality of life. In CSC, the leakage of subretinal fluid through defects in the retinal pigment epithelial layer's outer blood-retina barrier appears to occur secondary to choroidal abnormalities and dysfunction. The treatment of CSC is currently the subject of controversy, although recent data obtained from several large randomized controlled trials provide a wealth of new information that can be used to establish a treatment algorithm. Here, we provide a comprehensive overview of our current understanding regarding the pathogenesis of CSC, current therapeutic strategies, and an evidence-based treatment guideline for CSC. In acute CSC, treatment can often be deferred for up to 3-4 months after diagnosis; however, early treatment with either half-dose or half-fluence photodynamic therapy (PDT) combined with the photosensitive dye verteporfin may be beneficial in selected cases. In chronic CSC, half-dose or half-fluence PDT, which targets the abnormal choroid, should be considered the preferred treatment. If PDT is unavailable, chronic CSC with focal, non-central leakage on angiography may be treated using conventional laser photocoagulation. CSC with concurrent macular neovascularization should be treated with half-dose/half-fluence PDT and/or intravitreal injections of an anti-vascular endothelial growth factor compound. Given the current shortage of verteporfin and the paucity of evidence supporting the efficacy of other treatment options, future studies-ideally, well-designed randomized controlled trials-are needed in order to evaluate new treatment options for CSC.
PMID: 38301969
ISSN: 1873-1635
CID: 5626772

Hyporeflective Subretinal Lucency in Central Serous Chorioretinopathy

Bijon, Jacques; Freund, K Bailey
PMID: 38284952
ISSN: 1549-4713
CID: 5627822

Distinctive Optical Coherence Tomography Angiography and Indocyanine Green Angiography Imaging Patterns in Topiramate-Induced Choroidal Effusion

Bijon, Jacques; Flynn, Erin; Freund, K Bailey
PURPOSE/OBJECTIVE:To describe novel findings seen on optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in a young male patient presenting with bilateral topiramate-induced choroidal effusion. METHODS:Retrospective case report. A comprehensive ophthalmic examination was conducted and multimodal imaging techniques, including B-scan ultrasound, OCT, OCTA, and ICGA were analyzed. RESULTS:A male in his 30s presented with a myopic shift due to bilateral choroidal effusion induced by a medication containing topiramate prescribed for weight loss. ICGA showed multiple hypofluorescent spots within the choroid corresponding to areas of reduced OCTA flow signal in both the inner and deeper en face choroidal slabs. Symptoms and abnormal imaging findings resolved within five days of discontinuing the medication. CONCLUSION/CONCLUSIONS:Findings observed with OCTA and ICGA together suggest multifocal reversible areas of reduced choroidal vascular flow occurring in a topiramate-induced choroidal effusion. We propose that this transient hypoperfusion is due to compression from deeper choroidal vessels with a congested choroid.
PMID: 38109671
ISSN: 1937-1578
CID: 5612492

Central Bouquet Hemorrhage. Clinical and multimodal imaging features

Ramtohul, Prithvi; Au, Adrian; Kunkler, Anne L; Bacci, Tommaso; Dolz-Marco, Rosa; Gallego-Pinazo, Roberto; Yannuzzi, Nicolas; Sarraf, David; Freund, K Bailey
PURPOSE/OBJECTIVE:To describe the clinical characteristics, multimodal imaging features, and anatomic basis of a distinctive pattern of deep retinal hemorrhages located in the central fovea, a presentation referred to as "central bouquet hemorrhage" (CBH). METHODS:Retrospective, observational, multicenter case series of eyes with CBH. Multimodal imaging features were reviewed and analyzed. RESULTS:Ten eyes from 10 patients (4 women and 6 men), with a mean age of 55.6±21.7 years (range 25-84 years) were included. Underlying etiologies were neovascular age-related macular degeneration (40%), lacquer cracks in pathological myopia (30%), macular telangiectasia type 2 (10%), proliferative diabetic retinopathy (10%), and ocular trauma associated with angioid streaks (10%). On ophthalmoscopy, all eyes with CBH displayed a deep retinal hemorrhage with round margins in the central fovea and associated with petaloid hemorrhages radiating in the surrounding Henle fiber layer (HFL). Cross-sectional optical coherence tomography (OCT) showed a well-delineated round hyperreflective lesion involving the central foveal HFL/outer nuclear layer (ONL) in all cases. Accompanying hyperreflective hemorrhages tracking along the obliquely oriented HFL were present in all eyes. Resolution occurred in all patients, either spontaneously (30%) or after treatment with intravitreal anti-vascular endothelial growth factor injections (70%), and was associated with partial visual acuity improvement (from 20/113 to 20/36). CONCLUSION/CONCLUSIONS:"Central bouquet hemorrhage" is a novel descriptive term describing a characteristic round pattern of intraretinal blood in the fovea associated with HFL hemorrhage and encountered in a spectrum of macular disease.
PMID: 38109663
ISSN: 1539-2864
CID: 5612482

Reassessment of hyperautofluorescent rings in retinitis pigmentosa using novel retinal imaging techniques

Cabral, Diogo; Ramtohul, Prithvi; Freund, K. Bailey
SCOPUS:85168321794
ISSN: 2451-9936
CID: 5567622

Tamoxifen Retinopathy on High-Resolution OCT

Bijon, Jacques; Stein, Gregory; Freund, K Bailey
PMID: 37498267
ISSN: 2468-6530
CID: 5589992