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A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome from COVID-19

Bowdish, Michael E; Barkauskas, Christina E; Overbey, Jessica R; Gottlieb, Robert L; Osman, Keren; Duggal, Abhijit; Marks, Mary E; Hupf, Jonathan; Fernandes, Eustace; Leshnower, Bradley G; Golob, Jonathan L; Iribarne, Alexander; Rassias, Athos J; Moquete, Ellen G; O'Sullivan, Karen; Chang, Helena L; Williams, Judson B; Parnia, Sam; Patel, Nirav C; Desai, Nimesh D; Vekstein, Andrew M; Hollister, Beth A; Possemato, Tammie; Romero, Christian; Hou, Peter C; Burke, Elizabeth; Hayes, Jack; Grossman, Fred; Itescu, Silviu; Gillinov, Marc; Pagani, Francis D; O'Gara, Patrick T; Mack, Michael J; Smith, Peter K; Bagiella, Emilia; Moskowitz, Alan J; Gelijns, Annetine C
PMID: 36099435
ISSN: 1535-4970
CID: 5426132

Communication

Chapter by: Ely, Susan F.; Gill, James R.; Hayes, Jonathan; Lucas, Jonathan
in: Principles of Forensic Pathology: From Investigation to Certification by
[S.l.] : Elsevier, 2022
pp. 413-443
ISBN: 9780323986397
CID: 5500672

Comparison of Inappropriate Shocks and Other Health Outcomes Between Single- and Dual-Chamber Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Cardiac Death: Results From the Cardiovascular Research Network Longitudinal Study of Implantable Cardioverter-Defibrillators

Peterson, Pamela N; Greenlee, Robert T; Go, Alan S; Magid, David J; Cassidy-Bushrow, Andrea; Garcia-Montilla, Romel; Glenn, Karen A; Gurwitz, Jerry H; Hammill, Stephen C; Hayes, John; Kadish, Alan; Reynolds, Kristi; Sharma, Param; Smith, David H; Varosy, Paul D; Vidaillet, Humberto; Zeng, Chan X; Normand, Sharon-Lise T; Masoudi, Frederick A
BACKGROUND: In US clinical practice, many patients who undergo placement of an implantable cardioverter-defibrillator (ICD) for primary prevention of sudden cardiac death receive dual-chamber devices. The superiority of dual-chamber over single-chamber devices in reducing the risk of inappropriate ICD shocks in clinical practice has not been established. The objective of this study was to compare risk of adverse outcomes, including inappropriate shocks, between single- and dual-chamber ICDs for primary prevention. METHODS AND RESULTS: We identified patients receiving a single- or dual-chamber ICD for primary prevention who did not have an indication for pacing from 15 hospitals within 7 integrated health delivery systems in the Longitudinal Study of Implantable Cardioverter-Defibrillators from 2006 to 2009. The primary outcome was time to first inappropriate shock. ICD shocks were adjudicated for appropriateness. Other outcomes included all-cause hospitalization, heart failure hospitalization, and death. Patient, clinician, and hospital-level factors were accounted for using propensity score weighting methods. Among 1042 patients without pacing indications, 54.0% (n=563) received a single-chamber device and 46.0% (n=479) received a dual-chamber device. In a propensity-weighted analysis, device type was not significantly associated with inappropriate shock (hazard ratio, 0.91; 95% confidence interval, 0.59-1.38 [P=0.65]), all-cause hospitalization (hazard ratio, 1.03; 95% confidence interval, 0.87-1.21 [P=0.76]), heart failure hospitalization (hazard ratio, 0.93; 95% confidence interval, 0.72-1.21 [P=0.59]), or death (hazard ratio, 1.19; 95% confidence interval, 0.93-1.53 [P=0.17]). CONCLUSIONS: Among patients who received an ICD for primary prevention without indications for pacing, dual-chamber devices were not associated with lower risk of inappropriate shock or differences in hospitalization or death compared with single-chamber devices. This study does not justify the use of dual-chamber devices to minimize inappropriate shocks.
PMCID:5721776
PMID: 29122811
ISSN: 2047-9980
CID: 2771942

Is the "seat belt sign" associated with serious abdominal injuries in pediatric trauma?

Chidester, Sara; Rana, Ankur; Lowell, Wendi; Hayes, John; Groner, Jonathan
BACKGROUND: The 'seat belt sign' (SBS) has been reported to be highly associated with intra-abdominal injury. This study defines its predictive value in identifying injuries in a large pediatric trauma population. METHODS: At a level I pediatric trauma center, we performed a retrospective review of trauma flow sheets for all motor vehicle crash victims (ages, 0-20) requiring trauma team activation during 2005 and 2006. All patients with an abdominal SBS recorded were included in the analysis. RESULTS: Of 331 patients (mean age, 9.96 years), an SBS was present in 54 (16%) of these children. Abdominal injury was identified by computed tomography scan or intraoperatively in 12 (22%) of these children. Three (6%) children with SBS required operative intervention. Two had a bowel injuries and one had a negative laparoscopy. SBS and abdominal tenderness were reported in 30 (56%) patients; 8 (15%) of whom sustained abdominal injury. Of the 277 (84%) children without SBS, 36 (13%) had abdominal injuries. Four (11%) of these had a positive laparotomy with three having a bowel injuries. The relative risk of an abdominal injury given an SBS was 1.7 (CI 0.96-2.69; p = 0.078). Four (1.4%) children without SBS died of head injuries compared with zero with SBS. The SBS had a sensitivity of 25% and a specificity of 85%. CONCLUSIONS: The SBS was not significantly associated with abdominal injury in our population. Patients without SBS had a higher Injury Severity Score and accounted for all of the deaths. SBS may not be as predictive of abdominal injury as previously reported
PMID: 19590352
ISSN: 1529-8809
CID: 101126

Ecstasy (MDMA) deaths in New York City: a case series and review of the literature [Case Report]

Gill, James R; Hayes, Jonathan A; deSouza, Ian S; Marker, Elizabeth; Stajic, Marina
MDMA ('ecstasy') has gained renewed popularity as a drug of abuse. To access the epidemiology and causes of death of MDMA-positive fatalities, all deaths investigated by the OCME that tested positive for MDMA (22 deaths) between January 1997 and June 2000 were reviewed. There were three deaths in each 1997 and 1998, eleven in 1999, and five in the first part of 2000. Of these 22 deaths, 13 were due to acute drug intoxications, 7 due to mechanical injury (blunt trauma, gunshot wounds), and 2 due to a combination of natural disease and acute drug intoxication. Evidence of recent opiate and/or cocaine use was found in 7 of the acute intoxication deaths and in none of the traumatic or combination natural/intoxication deaths. The race of all decedents was White between the ages of 17-41 years, and 18 of 22 were men
PMID: 12064638
ISSN: 0022-1198
CID: 39433

Predictors and outcomes of cardiac complications following elective coronary bypass grafting

Charlson, M; Krieger, K H; Peterson, J C; Hayes, J; Isom, O W
Our objective was to determine the predictors of cardiac complications among a cohort of elective coronary artery bypass graft (CABG) surgery patients and to determine the relationship of such complications to subsequent quality of life and symptoms. A total of 248 patients were enrolled and 237 completed 6 month follow-up. The combined rate of both major and minor cardiac complications was 9.7% (n = 24). Patients in this study were evaluated preoperatively, monitored intraoperatively, followed immediately postoperatively and at 6 months. Major cardiac complications accounted for 3.6% (n = 9) and minor complications for 6% (n = 15). Using multivariable logistic regression analysis, the predictors of major cardiac complications were receiving diuretics preoperatively (p = .01) and increased time during cross-clamping (p = .006). At 6 months after surgery, 19% of the patients with postoperative cardiac complications experienced worsening of symptoms, in contrast to only 8% of those without cardiac complications (p = .03). We concluded that patients who were on preoperative diuretics and those who had longer cross-clamp times were at higher risk of cardiac complications. The majority of patients who had acute cardiac complications had improved function and symptoms at 6 months postoperatively.
PMID: 10591092
ISSN: 1081-650x
CID: 239812