Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci
Zubair, N; Graff, M; Ambite, J L; Bush, W S; Kichaev, G; Lu, Y; Manichaikul, A; Sheu, W H -H; Absher, D; Assimes, T L; Bielinski, S J; Bottinger, E P; Buzkova, P; Chuang, L -M; Chung, R -H; Cochran, B; Dumitrescu, L; Gottesman, O; Haessler, J W; Haiman, C; Heiss, G; Hsiung, C A; Hung, Y -J; Hwu, C -M; Juang, J -m J; Marchand, L L; Lee, I -T; Lee, W -J; Lin, L -A; Lin, D; Lin, S -Y; Mackey, R H; Martin, L W; Pasaniuc, B; Peters, U; Predazzi, I; Quertermous, T; Reiner, A P; Robinson, J; Rotter, J I; Ryckman, K K; Schreiner, P J; Stahl, E; Tao, R; Tsai, M Y; Waite, L L; Wang, T -D; Buyske, S; Chen, Y -D I; Cheng, I; Crawford, D C; Loos, R J F; Rich, S S; Fornage, M; North, K E; Kooperberg, C; Carty, C L
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown.We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians. The majority of signals found in these groups generalize to European Americans. While we uncovered signals unique to racial/ethnic populations, we also observed systematically consistent lipid associations across these groups. In African Americans, we identified three novel signals associated with HDL-C (LPL, APOA5, LCAT) and two associated with LDL-C (ABCG8, DHODH). In addition, using this population, we refined the location for 16 out of the 58 known MetaboChip lipid loci. These results can guide tailored screening efforts, reveal population-specific responses to lipid-lowering medications, and aid in the development of new targeted drug therapies.
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EMBASE:615000254
ISSN: 0964-6906
CID: 4901632
Measuring continued attachment to parents: The Continued Attachment Scale--Parent version
Berman, William H; Heiss, Glen E; Sperling, Michael B
Examined the psychometric properties of the Continued Attachment Scale--Parent version (CASP), which measures cognitive and emotional responses to the perceived separation from parents. Data from 115 male and 101 female college students were collected on the CASP and on scales selected to evaluate convergent and construct validities. The CASP showed good reliability. Scores were highly correlated with attachment scale scores that measure closeness, dependency, caring, and support. Correlations with measures of emotional state and personality differed for men and women but generally suggest that the scale assessed a distinct domain of experience related to continued closeness to parents and to depression.
PSYCH:1995-15784-001
ISSN: 0033-2941
CID: 56214