Try a new search

Format these results:

Searched for:

person:heissg01

in-biosketch:yes

Total Results:

6


Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci

Zubair, N; Graff, M; Ambite, J L; Bush, W S; Kichaev, G; Lu, Y; Manichaikul, A; Sheu, W H -H; Absher, D; Assimes, T L; Bielinski, S J; Bottinger, E P; Buzkova, P; Chuang, L -M; Chung, R -H; Cochran, B; Dumitrescu, L; Gottesman, O; Haessler, J W; Haiman, C; Heiss, G; Hsiung, C A; Hung, Y -J; Hwu, C -M; Juang, J -m J; Marchand, L L; Lee, I -T; Lee, W -J; Lin, L -A; Lin, D; Lin, S -Y; Mackey, R H; Martin, L W; Pasaniuc, B; Peters, U; Predazzi, I; Quertermous, T; Reiner, A P; Robinson, J; Rotter, J I; Ryckman, K K; Schreiner, P J; Stahl, E; Tao, R; Tsai, M Y; Waite, L L; Wang, T -D; Buyske, S; Chen, Y -D I; Cheng, I; Crawford, D C; Loos, R J F; Rich, S S; Fornage, M; North, K E; Kooperberg, C; Carty, C L
Genome-wide association studies have identified over 150 loci associated with lipid traits, however, no large-scale studies exist for Hispanics and other minority populations. Additionally, the genetic architecture of lipid-influencing loci remains largely unknown.We performed one of the most racially/ethnically diverse fine-mapping genetic studies of HDL-C, LDL-C, and triglycerides to-date using SNPs on the MetaboChip array on 54,119 individuals: 21,304 African Americans, 19,829 Hispanic Americans, 12,456 Asians, and 530 American Indians. The majority of signals found in these groups generalize to European Americans. While we uncovered signals unique to racial/ethnic populations, we also observed systematically consistent lipid associations across these groups. In African Americans, we identified three novel signals associated with HDL-C (LPL, APOA5, LCAT) and two associated with LDL-C (ABCG8, DHODH). In addition, using this population, we refined the location for 16 out of the 58 known MetaboChip lipid loci. These results can guide tailored screening efforts, reveal population-specific responses to lipid-lowering medications, and aid in the development of new targeted drug therapies.
Copyright
EMBASE:615000254
ISSN: 0964-6906
CID: 4901632

Guide to psychological testing and psychiatric rating scales

Chapter by: Heiss, Glenn; Manley, Myrl RS
in: Psychiatry clerkship guide by Manley, Myrl RS [Eds]
Philadelphia PA : Mosby/Elsevier, 2007
pp. 81-86
ISBN: 1416031324
CID: 5568

Timing bias in the psychiatry subject examination of the National Board of Medical Examiners

Manley, Myrl; Heiss, Glenn
OBJECTIVE: The authors investigate whether the timing of the psychiatry clerkship influences scores on the National Board of Medical Examiners (NBME) subject exam as has been reported for other clerkships. The authors attempt to identify which clerkships, if any, offer an advantage when taken before psychiatry. METHODS: Mean aggregate exam scores over 4 years were calculated according to clerkship sequence. An analysis of variance was conducted to assess the effect of sequence on test scores. Pairwise comparisons (t tests) were performed to determine whether students who completed one particular clerkship before psychiatry scored higher on the subject examination than students who completed the clerkship after psychiatry. RESULTS: Students who take psychiatry near the end of the clerkship sequence score higher than students who take psychiatry as a first clerkship. The differences are small but significant. The mean score for students taking psychiatry first was 72.81, compared to a score of 78.51 for students taking the clerkship last. No single clerkship is more likely than another to increase test scores when taken before psychiatry. CONCLUSIONS: Clerkship directors must be aware of the timing bias in subject exam scores. However, the bias may not be sufficient to justify abandoning use of the subject examinations
PMID: 16609116
ISSN: 1042-9670
CID: 68744

The relationship between loneliness and psychiatric symptomatology over the course of treatment of an outpatient psychiatric episode [Dissertation] [Dissertation]

Heiss, Glen Edward
The correlation between feelings of loneliness and various psychiatric symptoms has been well-documented. Most of the research in this area has been cross-sectional, however, and there has been little examination of the loneliness-symptomatology relationship over time. The present research addressed this gap by administering standardized instruments to two clinical samples at multiple time points. The first sample was comprised of employees and dependents of employees of the Xerox Corporation (N = 101) who received outpatient mental health and/or substance abuse treatment following an episode of inpatient or intensive outpatient treatment. These individuals completed a measure of loneliness and relevant symptom scales at three points over the first twelve months of treatment. The second sample was comprised of individuals who sought treatment through one of two outpatient facilities in the Northeast ( N = 240). These individuals completed a standard loneliness measure and a general index of symptomatology at two points during their first two months in treatment. In both samples feelings of loneliness and psychiatric symptoms were correlated at every assessment point among. subjects diagnosed with depressive disorders, anxiety disorders and adjustment disorders. No relationship was found between feelings of loneliness and symptoms among subjects with substance abuse diagnoses, but the number of individuals with these diagnoses was rather small. General symptom severity and feelings of loneliness were correlated at most assessment points. Initial symptom severity was observed to exert a significant predictive influence on subsequent loneliness in both studies. Variables such as diagnosis, gender and ethnicity did not mediate the loneliness-symptomatology relationship. Marital status, however, did exert a mediating influence on this relationship; the correlation between loneliness and symptomatology was significantly stronger among individuals who were not married than it was among married subjects. These results extend previous research in this area by illustrating that feelings of loneliness persist and tend to remain correlated with psychiatric symptomatology throughout treatment across multiple diagnostic categories. This research also illustrates that some interpersonal variables (e.g. marital status) exert a noteworthy influence on the relationship between loneliness and psychiatric symptomatology.
PSYCH:2000-95014-043
ISSN: 0419-4217
CID: 56230

Five scales in search of a construct: exploring continued attachment to parents in college students

Heiss, G E; Berman, W H; Sperling, M B
The multitude of measures and differences across self-report indices of continued parental attachment raise questions regarding the validity and meaning of these scales. The purpose of this study was to examine the convergent and construct validity of 5 measures of continued parental attachment. Five attachment scales and 6 personality scales were administered to 216 undergraduate students. Factor analyses and correlational analyses indicate that the 5 attachment measures differentiate healthy from pathological bonding with parents, the construct being assessed has multiple dimensions, and scores on these attachment measures are correlated with personify variables as would be expected. These attachment scales appear to assess a construct that is related to attachment, although they may be more illustrative of the general affective quality of relationships. Subsequent assessment efforts should employ more specific ratings and measure concrete behavioral manifestations of attachment to most effectively examine the construct.
PMID: 16367659
ISSN: 0022-3891
CID: 3798002

Measuring continued attachment to parents: The Continued Attachment Scale--Parent version

Berman, William H; Heiss, Glen E; Sperling, Michael B
Examined the psychometric properties of the Continued Attachment Scale--Parent version (CASP), which measures cognitive and emotional responses to the perceived separation from parents. Data from 115 male and 101 female college students were collected on the CASP and on scales selected to evaluate convergent and construct validities. The CASP showed good reliability. Scores were highly correlated with attachment scale scores that measure closeness, dependency, caring, and support. Correlations with measures of emotional state and personality differed for men and women but generally suggest that the scale assessed a distinct domain of experience related to continued closeness to parents and to depression.
PSYCH:1995-15784-001
ISSN: 0033-2941
CID: 56214