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Absence of a luteotropic effect of prolactin and human placental lactogen on the human corpus luteum of pregnancy

Quagliarello, J; Goldsmith, L; Szlachter, N; Hochman, J; Weiss, G
PMID: 7395613
ISSN: 0065-2229
CID: 105267

Serum immunoreactive relaxin concentrations in human pregnancy, labor and the puerperium

Quagliarello, J; Nachtigall, R; Goldsmith, L T; Hochman, J; Steinetz, B G; O'Bryen, E M; Weiss, G
PMID: 463632
ISSN: 0065-2598
CID: 105272

Distribution of relaxin in women during pregnancy

Weiss G; O'Byrne EM; Hochman J; Steinetz BG; Goldsmith L; Flitcraft JG
The purpose of this study was to determine by RIA the concentrations of relaxin in various compartments and tissues in pregnant women. Ten pairs of maternal venous and cord blood were studied. The mean relaxin concentrations, in immunoreactive equivalents of porcine relaxin, were 0.683 ng/ml in maternal serum and 0.009 ng/ml in cord serum. Relaxin was undetectable in 8 of 9 samples of amniotic fluid. Mean concentrations of relaxin in pg immunoreactive equivalents of porcine hormone per mg protein, from maternal tissues at term pregnancy were as follows: fat 96 (N = 5), myometrium 47 (N = 4), skin 62 (N = 5), placenta 51 (N = 9), and corpus luteum 13,000 (N = 8). These data suggest that little relaxin crosses the placenta and little is produced in the fetus. Contrary to prior suggestions that relaxin may also be a placental product, relaxin appears to be solely produced in the corpus luteum, making it the only peripherally measured hormone that can be used as an index of luteal activity in pregnancy
PMID: 724175
ISSN: 0029-7844
CID: 67185

Relaxin bioactivity and immunoactivity in human corpora lutea

O'Byrne, E M; Flitcraft, J F; Sawyer, W K; Hochman, J; Weiss, G; Steinetz, B G
Relaxin-like activity in extracts of corpora lutea (CL) from pregnant and non-pregnant women was determined by radioimmunoassay and by guinea pig pubic symphysis palpation assay. The biologically determined activity paralled the immunoactivity of extracts of CL of pregnancy. The relaxin content of CL of non-pregnant women was too low for detection by the bioassay.
PMID: 744044
ISSN: 0013-7227
CID: 162689

Serum relaxin concentrations in prostaglandin- and oxytocin-induced labor in women

Hochman J; Weiss G; Steinetz BG; O'Byrne EM
PMID: 629294
ISSN: 0002-9378
CID: 67186

Effect of human placental lactogen upon the human corpus luteum of late pregnancy

Goldsmith LT; Hochman JA; Weiss G
To acertain whether human placental lactogen (HPL) functions as a luteotropin during pregnancy in humans, studies were performed to determine if receptors for HPL are present in cells of the human corpus luteum of late pregnancy. Preparations of 125I-HPL which demonstrated specific binding to late pregnant rabbit mammary gland cell homogenates showed specific binding of less than 2.5% to homogenates of human corpora lutea of late pregnancy. These studies indicate that HPL is not luteotropic at this stage of pregnancy in humans. The action of HPL upon the corpus luteum appears to vary considerably according to species
PMID: 35449
ISSN: 0378-7346
CID: 67187

Relaxin

Schwabe, C; Steinetz, B; Weiss, G; Segaloff, A; McDonald, J K; O'Byrne, E; Hochman, J; Carriere, B; Goldsmith, L
PMID: 366679
ISSN: 0079-9963
CID: 162668

Secretion of progesterone and relaxin by the humancorpus luteum at midpregnancy and at term

Weiss G; O'Byrne M; Hochman JA; Goldsmith LT; Rifkin I; Steinetz BG
PIP: The secretion of progesterone (P) and relaxin (R):by the human corpus luteum at midpregnancy and at term was studied in 19 women, 6 of whom had their pregnancies terminated by hysterotomy at 14-18 weeks and 13 whose pregnancies went to term and were delivered by Caesarean section. Luteectomies were performed on 6 of the women at the time of Caesarean section. P and R levels were measured. R section correlated well with luteal P secretion. After Caesarean section at term the decline in serum P was parallel to that observed after hysterotomya at midtrimester. Absolute levels of P are higher at term. P decline after luteectomy was precipitous compared with Caesarean section. Results indicate that the corpus luteum in the human remains active throughout pregnancy. O
PMID: 927758
ISSN: 0029-7844
CID: 67188

SECRETION OF PROGESTERONE AND RELAXIN BY HUMAN PREGNANCY CORPUS-LUTEUM [Meeting Abstract]

Weiss, G; Obyrne, EM; Hochman, JA; Goldsmith, LT; Steinetz, BG
ISI:A1977CX35100080
ISSN: 0017-5986
CID: 29624

Induction of an LH surge with estradiol benzoate in a patient with incomplete testicular feminization syndrome [Case Report]

Hochman J; Ganguly M; Weiss G
A 31-year-old patient with incomplete testicular feminization syndrome characterized by a 46, XY karyotype in a phenotypic female with absent mullerian structures, marked clitoromegaly, testes and wolffian duct structures, partial labioscrotal fold fusion, and male levels of circulating androgens is described. She was challenged with estradiol benzoate (EB) to simulate the preovulatory surge of estradiol seen in cycling women. This EB challenge resulted in a negative feedback response for FSH but an LH surge similar to that induced with EB in cycling women. This suggests that in the incomplete testicular feminization syndrome there is hypothalamic or pituitary resistance to the blocking effects of androgens on LH surge production
PMID: 831170
ISSN: 0029-7844
CID: 67189