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Baseline brain function in the preadolescents of the ABCD Study

Chaarani, B; Hahn, S; Allgaier, N; Adise, S; Owens, M M; Juliano, A C; Yuan, D K; Loso, H; Ivanciu, A; Albaugh, M D; Dumas, J; Mackey, S; Laurent, J; Ivanova, M; Hagler, D J; Cornejo, M D; Hatton, S; Agrawal, A; Aguinaldo, L; Ahonen, L; Aklin, W; Anokhin, A P; Arroyo, J; Avenevoli, S; Babcock, D; Bagot, K; Baker, F C; Banich, M T; Barch, D M; Bartsch, H; Baskin-Sommers, A; Bjork, J M; Blachman-Demner, D; Bloch, M; Bogdan, R; Bookheimer, S Y; Breslin, F; Brown, S; Calabro, F J; Calhoun, V; Casey, B J; Chang, L; Clark, D B; Cloak, C; Constable, R T; Constable, K; Corley, R; Cottler, L B; Coxe, S; Dagher, R K; Dale, A M; Dapretto, M; Delcarmen-Wiggins, R; Dick, A S; Do, E K; Dosenbach, N U F; Dowling, G J; Edwards, S; Ernst, T M; Fair, D A; Fan, C C; Feczko, E; Feldstein-Ewing, S W; Florsheim, P; Foxe, J J; Freedman, E G; Friedman, N P; Friedman-Hill, S; Fuemmeler, B F; Galvan, A; Gee, D G; Giedd, J; Glantz, M; Glaser, P; Godino, J; Gonzalez, M; Gonzalez, R; Grant, S; Gray, K M; Haist, F; Harms, M P; Hawes, S; Heath, A C; Heeringa, S; Heitzeg, M M; Hermosillo, R; Herting, M M; Hettema, J M; Hewitt, J K; Heyser, C; Hoffman, E; Howlett, K; Huber, R S; Huestis, M A; Hyde, L W; Iacono, W G; Infante, M A; Irfanoglu, O; Isaiah, A; Iyengar, S; Jacobus, J; James, R; Jean-Francois, B; Jernigan, T; Karcher, N R; Kaufman, A; Kelley, B; Kit, B; Ksinan, A; Kuperman, J; Laird, A R; Larson, C; LeBlanc, K; Lessov-Schlagger, C; Lever, N; Lewis, D A; Lisdahl, K; Little, A R; Lopez, M; Luciana, M; Luna, B; Madden, P A; Maes, H H; Makowski, C; Marshall, A T; Mason, M J; Matochik, J; McCandliss, B D; McGlade, E; Montoya, I; Morgan, G; Morris, A; Mulford, C; Murray, P; Nagel, B J; Neale, M C; Neigh, G; Nencka, A; Noronha, A; Nixon, S J; Palmer, C E; Pariyadath, V; Paulus, M P; Pelham, W E; Pfefferbaum, D; Pierpaoli, C; Prescot, A; Prouty, D; Puttler, L I; Rajapaske, N; Rapuano, K M; Reeves, G; Renshaw, P F; Riedel, M C; Rojas, P; de la Rosa, M; Rosenberg, M D; Ross, M J; Sanchez, M; Schirda, C; Schloesser, D; Schulenberg, J; Sher, K J; Sheth, C; Shilling, P D; Simmons, W K; Sowell, E R; Speer, N; Spittel, M; Squeglia, L M; Sripada, C; Steinberg, J; Striley, C; Sutherland, M T; Tanabe, J; Tapert, S F; Thompson, W; Tomko, R L; Uban, K A; Vrieze, S; Wade, N E; Watts, R; Weiss, S; Wiens, B A; Williams, O D; Wilbur, A; Wing, D; Wolff-Hughes, D; Yang, R; Yurgelun-Todd, D A; Zucker, R A; Potter, A; Garavan, H P
The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.
PMID: 34099922
ISSN: 1546-1726
CID: 4950912

Change in shock index as a predictor of transfusion requirement [Meeting Abstract]

Schmidt, A; Wells, M; Hoffman, E; Ramani, S; Kunzier, N; Vintzileos, A
INTRODUCTION: Early identification of PPH is difficult. Shock index (SI) (SI=HR/SBP) of (.0.9) has demonstrated good prediction of PPH, and identify identification of patients requiring massive transfusion. Our objective is to determine if there is a change in SI on admission to postpartum or at time of transfusion after which there is an increased transfusion requirement or morbidity.
METHOD(S): IRB approved, retrospective cohort of patients who received blood transfusion at a University based hospital, 2017-2018. SI calculated; at time of admission, after delivery, and prior to transfusion. Patients with invasive carcinoma, with fetus of non-viable gestational age, and incomplete charts were excluded. Spearman correlate coefficient, univariable logistic regression, and ROC analyses were performed.
RESULT(S): 160 patients; 117/160 (73%) delivered by cesarean, 37/ 160 (23%) vaginally, and 6/160 (4%) operative vaginal delivery. Mean admission hemoglobin was 10.8 (6 1.5). Median EBL was 1320 mL (250-6000 mL). 77/160 (48%) of patients received 2 units of PRBC, 26/ 160 (17%) received 3 units of PRBC, 24/160 (15%) received 4 units of PRBC and 33/160 (20%) received >=5 units of PRBC. Change in SI from admission to postpartum had a correlation coefficient of 0.022 and a P value of .78. Change in SI from admission to pre-transfusion had a correlation coefficient of 0.128 and a P value of .11.
CONCLUSION(S): Changes in SI from admission to immediately postpartum or pre-transfusion do not show any correlation or predictive value for increasing morbidity, or transfusion requirements. This demonstrates change in SI is a poor predictor of morbidity and transfusion requirements
EMBASE:633633437
ISSN: 1873-233x
CID: 4721122

National Institutes of Health state-of-the-science conference statement: prevention of fecal and urinary incontinence in adults

Landefeld, C Seth; Bowers, Barbara J; Feld, Andrew D; Hartmann, Katherine E; Hoffman, Eileen; Ingber, Melvin J; King, Joseph T Jr; McDougal, W Scott; Nelson, Heidi; Orav, Endel John; Pignone, Michael; Richardson, Lisa H; Rohrbaugh, Robert M; Siebens, Hilary C; Trock, Bruce J
PMID: 18268289
ISSN: 1539-3704
CID: 132259

Sex and Gender : Women's Health Cooperative

Evolving paradigms in women's health

Hoffman, Eileen
(Website)
CID: 1371912

The causes and consequences of overactive bladder

Miller, Jane; Hoffman, Eileen
Overactive bladder (OAB) is a syndrome characterized by symptoms of urinary urgency with or without urgency urinary incontinence (UUI), usually with frequency and nocturia. OAB affects approximately 17% of women in the United States and Europe. The causes of OAB, as with many bladder disorders, are multifactorial and are not completely understood. The primary functions of the lower urinary tract (bladder and bladder outlet mechanism) are storage and evacuation of urine. The bladder and the micturition cycle are under complex neural control involving both the sympathetic and parasympathetic nervous systems. Micturition may occur in response to the activation of receptors in the bladder muscle and detection of chemical stimuli by receptors within the bladder lining. Neurogenic or myogenic bladder dysfunction can lead to the symptoms of urgency, frequency, and UUI that characterize OAB. The consequences of this condition are far-reaching and include direct medical consequences and coping strategies that adversely affect quality of life. Although the prevalence of OAB increases with age, it is not a normal consequence of aging. Antimuscarinic agents (e.g., oxybutynin, tolterodine, trospium, solifenacin, and darifenacin) have demonstrated efficacy for the treatment of OAB symptoms in multiple clinical trials. This review explores the physiological basis for OAB, the effects of OAB on health-related quality of life, and the pharmacotherapies that may provide relief to patients with this distressing condition
PMID: 16620184
ISSN: 1540-9996
CID: 75203

First World Congress on Gender Specific Medicine : Men, Women and Medicine : a new view of sex/gender differences and aging, 2006

Translating Sex and Gender Science into Clinical Practice: National Partnerships and Local Care

Trott, Justina A; Hoffman, Eileen
(Website)
CID: 1371922

Psychologists in women's primary care and obstetrics-gynecology: consultation and treatment issues

Chapter by: Coons, Helen L; Morgenstern, Diana; Hoffman, Eileen M; Striepe, Meg I; Buch, Cathy
in: Primary care psychology by Frank, Robert G [Eds]
Washington, DC : American Psychological Association, 2004
pp. ?-?
ISBN: 9781591470540
CID: 1368222

Women's health and complexity science

Hoffman E
Conceptual frameworks in science have shifted from reductionism and its focus on ever-smaller parts to complexity, an outgrowth of chaos theory that views those parts in relation to one another, to the larger entity they form and to the environment in which that entity exists. Examples of this conceptual shift are occurring in many areas of science, but nowhere is it more germane than in the medical sciences that serve women. After a historical focus on reproduction and the development of obstetrics-gynecology, medicine has now gained a broader view of the woman using sex- and gender-based science, and a new field called 'women's health' is evolving. Complexity science does not invalidate or eliminate the need for reductionist science, it simply makes a wider array of phenomena understandable. Its method allows going beyond the metaphor of the body as a machine and challenges the user to re-examine how health and illness are understood. This article explores how these changes in science must inform the development of an academic discipline in women's health. The conceptual framework of complexity science also advances the discussions about women's health from reproduction to a totally new and exciting exploration of the interactions between reproduction and all other organ functioning that occurs in women in the contexts of their lives
PMID: 11078669
ISSN: 1040-2446
CID: 25934

Changing perspectives on sex and gender in medical education

Hoffman E; Magrane D; Donoghue GD
PMID: 11078660
ISSN: 1040-2446
CID: 25935

Quality in women's health: the organizing principles for the NAWH (National Association for Women's Health) trade association

Shelley D; Hoffman E; Menitoff R; Maraldo P
Quality in women's health care has been assessed with preventive measures such as mammograms and pap smears, and obstetrical measures, such as prenatal care. Although awareness about sex and gender differences among researchers, health professionals, and women themselves has grown dramatically over the last 10 years, health care policy and medical education have not been influenced to any significant degree. Sex and gender differences have not been developed for a wider range of services, such as diagnosis and treatment of acute or chronic conditions, outside of reproductive health. This article reviews contemporary women's health issues and discusses the need for collaboration among multiple stakeholder groups within the health care industry to address quality in women's health care
PMID: 11183585
ISSN: 1063-8628
CID: 25933