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13


Cross-neutralization of influenza A viruses mediated by a single antibody loop

Ekiert, Damian C; Kashyap, Arun K; Steel, John; Rubrum, Adam; Bhabha, Gira; Khayat, Reza; Lee, Jeong Hyun; Dillon, Michael A; O'Neil, Ryann E; Faynboym, Aleksandr M; Horowitz, Michael; Horowitz, Lawrence; Ward, Andrew B; Palese, Peter; Webby, Richard; Lerner, Richard A; Bhatt, Ramesh R; Wilson, Ian A
Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mechanism is available to antibodies. Here we report the isolation and characterization of an antibody called C05, which neutralizes strains from multiple subtypes of influenza A virus, including H1, H2 and H3. X-ray and electron microscopy structures show that C05 recognizes conserved elements of the receptor-binding site on the haemagglutinin surface glycoprotein. Recognition of the haemagglutinin receptor-binding site is dominated by a single heavy-chain complementarity-determining region 3 loop, with minor contacts from heavy-chain complementarity-determining region 1, and is sufficient to achieve nanomolar binding with a minimal footprint. Thus, binding predominantly with a single loop can allow antibodies to target small, conserved functional sites on otherwise hypervariable antigens.
PMCID:3538848
PMID: 22982990
ISSN: 1476-4687
CID: 2291362

Clinical image. MR demonstration of submucosal fat in a patient with Crohn's disease [Case Report]

Funt SA; Krinsky G; Horowitz L
PMID: 8933795
ISSN: 0363-8715
CID: 12493

RENAL PATHOLOGY IN INFANTS AND CHILDREN WITH AIDS [Meeting Abstract]

Horowitz, L; Greco, MA; Feiner, HD
ISI:A1988P728900689
ISSN: 0893-3952
CID: 31464

RENAL PATHOLOGY IN INFANTS AND CHILDREN WITH AIDS [Meeting Abstract]

Horowitz, L; Greco, MA; Feiner, HD
ISI:A1988L865000693
ISSN: 0023-6837
CID: 31561

DIVERTICULITIS EVALUATED BY COMPUTED-TOMOGRAPHY [Meeting Abstract]

HULNICK, DH; MEGIBOW, AJ; BALTHAZAR, EJ; HOROWITZ, L
ISI:A1986A921200601
ISSN: 0016-5085
CID: 41455

48 DAYS OF FEVER, PAIN IN A HEALTHY OLD MAN

HOROWITZ, L
ISI:A1983QF44800010
ISSN: 8750-2836
CID: 40561

Alimentary tract involvement in Kaposi sarcoma: radiographic and endoscopic findings in 25 homosexual men

Rose HS; Balthazar EJ; Megibow AJ; Horowitz L; Laubenstein LJ
An outbreak of Kaposi sarcoma has recently occurred among young homosexual men. It differs from the classic form in its virulence and preponderance of systemic manifestations. Twenty-five homosexual men with a mean age of 37 and biopsy-proven Kaposi sarcoma received extensive gastrointestinal evaluations. Twelve patients (48%) had evidence of gastrointestinal involvement by radiography and/or endoscopy. Lesions were found in the larynx, oropharynx, esophagus, stomach, duodenum, and colon. Radiographically they ranged from minimally elevated submucosal lesions, some with central ulceration, to polypoid defects. Abdominal CT was obtained in 18 patients, 11 of whom showed abnormalities. Of those with abnormal CT, 50% had retroperitoneal adenopathy. The gastrointestinal radiographic findings with endoscopic correlation in this unusual group of patients is discussed
PMID: 6981924
ISSN: 0361-803x
CID: 43731

Radiological assessment of pharyngoesophageal dysfunction with emphasis on cricopharyngeal myotomy [Case Report]

Redmond, P; Berliner, L; Ambos, M; Horowitz, L
PMID: 7072686
ISSN: 0002-9270
CID: 576892

DISSEMINATED KAPOSIS SARCOMA - INVOLVEMENT OF THE GI TRACT AMONG A GROUP OF HOMOSEXUAL MEN [Meeting Abstract]

Stern, JO; Dieterich, D; Faust, M; Laubenstein, L; Horowitz, L
ISI:A1982NK72200736
ISSN: 0016-5085
CID: 30417

Dysphagia in Parkinson's disease [Case Report]

Lieberman AN; Horowitz L; Redmond P; Pachter L; Lieberman I; Leibowitz M
PMID: 6778203
ISSN: 0002-9270
CID: 64025