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The Importance of a Multidisciplinary Approach to Lung Cancer Patients in the Era of Immuno-Oncology - A Case Report of Multi-Organ Toxicity with Checkpoint Inhibitor Treatment [Meeting Abstract]

Weintraub, S.; Newman, J.; Thomas, R.; Seetharamu, N.
ISI:000792480403219
ISSN: 1073-449x
CID: 5339682

Epidemiology and clinicopathological features of lung cancer in patients with prior history of breast cancer

Wang, Kevin Y; Newman, James; Lee, Chung-Shien; Seetharamu, Nagashree
Breast cancer is the most common malignancy in women, and lung cancer, the leading cause of cancer-related mortality in the United States, is the most common subsequent primary cancer among breast cancer survivors. In this review, we examine the risk factors that cause subsequent primary lung cancer after breast cancer (referred to herein as BCLC patients) as well as the prognostic factors that may affect survival. Notable clinicopathological features include patient characteristics such as age, smoking history, and the presence of EGFR or BRCA mutations, as well as factors related to the treatment of breast cancer such as radiation, surgery, chemotherapy, stage, anti-estrogen therapy, and ER/PR/HER2 status.
PMCID:8155786
PMID: 34104436
ISSN: 2050-3121
CID: 4899872

Treatment with Granulocyte-colony Stimulating Factor (G-CSF) is not associated with Increased Risk of Brain Metastasis in Patients with De Novo Stage IV Breast Cancer

Fujii, Takeo; Rehman, Hasan; Chung, Su Yun; Shen, Janice; Newman, James; Wu, Vernon; Hines, Adam; Azimi-Nekoo, Elham; Fayyaz, Fatima; Lee, Meeyoung; Raptis, George; Egeblad, Mikala; Zhu, Xinhua
PMCID:8364654
PMID: 34405029
ISSN: 1837-9664
CID: 5339672

Back to the well: Can patients with advanced non-small cell lung cancer benefit from changing PD-1/PD-L1 inhibitors after progression? [Meeting Abstract]

Newman, James; Lee, Chung-Shien; McGovern, Kerri; Seetharamu, Nagashree
ISI:000708120305161
ISSN: 0732-183x
CID: 5339692

Burden of Proof: Evaluating the Efficacy of Tumor Mutational Burden (TMB) in Predicting Response to Immune Checkpoint Inhibitors

Newman, James; Seetharamu, Nagashree; Saif, Muhammad Wasif
PMCID:7769129
PMID: 33377136
ISSN: n/a
CID: 4731812

Simple parameters to solve a complex issue: predicting response to checkpoint inhibitor therapy in lung cancer

Newman, James; Preeshagul, Isabel; Kohn, Nina; Devoe, Craig; Seetharamu, Nagashree
Background/UNASSIGNED:Noninvasive biomarkers predicting immune checkpoint inhibitor (ICI) response are urgently needed. We evaluated the predictive value of pretreatment neutrophil-to-lymphocyte ratio (NLR), smoking history, smoking intensity, BMI and programmed death ligand 1 (PD-L1) expression in non-small-cell lung cancer (NSCLC) patients treated with ICIs. Materials & methods/UNASSIGNED:Single-center retrospective study included 137 patients from July 2015 to February 2018. Outcomes included 3-month disease control rate, progression-free survival, and overall survival. Predictive value of biomarkers was assessed independently and in a multivariable model. Results/UNASSIGNED:NLR was associated with all outcomes. Smoking history was predictive of progression-free survival and smoking intensity was predictive of disease control rate. BMI and PD-L1 were not associated with any outcome. High BMI was associated with low NLR. Conclusion/UNASSIGNED:Simple clinical biomarkers can predict response to ICIs. A score incorporating both clinical factors and established tissue/serum biomarkers may be useful in identifying NSCLC patients who would benefit from ICIs.
PMCID:8162145
PMID: 34084210
ISSN: 1758-1974
CID: 4892022

A single-center analysis of adjuvant sequential versus 'sandwich' chemoradiotherapy for patients with stage III endometrial cancer. [Meeting Abstract]

Shen, Janice; Newman, James; Hernandez, Jennifer; Bloom, Beatrice; Lee, Jean Kyung; John, Veena S.
ISI:000560368306455
ISSN: 0732-183x
CID: 5339722

Meta-analysis and systematic review of the cardiotoxicity of TAS-102. [Meeting Abstract]

Lopez, Carlos Alberto; Azimi-Nekoo, Elham; Chung, Su Yun; Newman, James; Shen, Janice; Saif, Wasif M.
ISI:000560368305416
ISSN: 0732-183x
CID: 5339732

Predictive value of baseline clinicopathological factors in non-small cell lung cancer (NSCLC) patients on checkpoint inhibitors (CPI). [Meeting Abstract]

Newman, James; Preeshagul, Isabel Ruth; Sullivan, Kevin M.; Kohn, Nina; Seetharamu, Nagashree
ISI:000487345800498
ISSN: 0732-183x
CID: 5339702

Does systemic treatment add value to stereotactic body radiation therapy for locoregional control in head and neck squamous cell carcinoma patients? [Meeting Abstract]

Tufano, Andrea M.; Newman, James; Gogineni, Emile; Karten, Jessie L.; Paul, Doru; Ghaly, Maged; Seetharamu, Nagashree
ISI:000487345801731
ISSN: 0732-183x
CID: 5339712