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Seizure disorders: Part 2. Treatment

Kammerman S; Wasserman L
PMCID:1071539
PMID: 11527850
ISSN: 0093-0415
CID: 26674

Seizure disorders: Part 1. Classification and diagnosis

Kammerman S; Wasserman L
PMCID:1071497
PMID: 11483551
ISSN: 0093-0415
CID: 26715

Duration of asthma and physiologic outcomes in elderly nonsmokers

Cassino C; Berger KI; Goldring RM; Norman RG; Kammerman S; Ciotoli C; Reibman J
Airway and alveolar inflammation have been described in asthma. Prolonged inflammation may lead to airway remodeling, which can result in physiologic abnormalities. Elderly lifetime nonsmokers are an ideal population in which to examine the consequences of longstanding asthma. To test the hypothesis that airflow limitation and hyperinflation are associated with the duration of asthma, we evaluated airflow and lung volumes in a cohort of elderly asthmatic individuals. All subjects were > 60 yr of age and were lifetime nonsmokers (n = 75). Patients with asthma of long duration (LDA; n = 38) had asthma for >/= 26 yr (median = 40.0 yr); patients with asthma of short duration (SDA; n = 37) had asthma for < 26 yr (median = 9 yr). Patients with LDA had a significantly lower FEV(1)% predicted than did those with SDA (59.5 +/- 2.6% versus 73.8 +/- 3.1% [mean +/- SEM], respectively; p < 0.007). Regression analysis demonstrated that duration of asthma was inversely associated with FEV(1)% predicted (r = 0.264, p < 0.03). After bronchodilator administration, the patients with LDA continued to show airflow obstruction (FEV(1)% predicted = 65.4 +/- 2.9). Only 18% of patients with LDA attained a normal postbronchodilator FEV(1), whereas 50% of those with SDA were able to do so (p < 0.003). The FRC% predicted was significantly higher in subjects with LDA than in those with SDA (142.9 +/- 5.6 versus 124.1 +/- 4.4, respectively, p < 0.01). Multiple regression analysis revealed an association between FRC and duration of asthma that was independent of the degree of airflow limitation. These data suggest that the duration of asthma is associated with the degree of airflow limitation and hyperinflation. Moreover, these abnormalities can become irreversible over time, and may reflect distal airway and/or parenchymal changes as well as proximal airway remodeling
PMID: 11029356
ISSN: 1073-449x
CID: 39539

Tobacco use among adult inner city patients with asthma [Meeting Abstract]

Cassino, C; Alcabes, P; Kammerman, S; Reibman, J
ISI:000082237104211
ISSN: 1073-449x
CID: 53892

Effect of maternal asthma on performance of parenting tasks and children's school attendance

Cassino C; Auerbach M; Kammerman S; Birgfeld E; Bordman I; Ciotoli C; Reibman J
We evaluated the effects of maternal asthma on specific parameters of family function including the children's school attendance and mother's performance of basic parenting tasks. A case-controlled study of mothers with asthma (MA; n = 24) with children under the age of 13 and matched mothers without asthma (CM; n = 27) was performed. Children of mothers with asthma had a significantly impaired ability to attend school compared to children of control mothers (odds ratio = 15, 95% CI). Twenty-two percent of MA reported that their asthma caused their children to miss school at least once per month. In addition, 27% of MA reported that their children were regularly late for school because of the mother's asthma. Only 5% of the control mothers reported that their health caused their children to miss school, and none reported lateness. Asthma also impaired the ability of the MA to perform basic parenting tasks such as dressing children and preparing meals for children. These adverse effects of parental asthma on children's school attendance and parenting represent previously unappreciated indirect costs of asthma and may have immediate as well as future consequences
PMID: 9428296
ISSN: 0277-0903
CID: 57113

Immunoglobulin abnormalities in Paget's disease of bone

Buxbaum, J N; Kammerman, S
Several patients with Paget's disease have been reported to have monoclonal IgM proteins in their serum. We have systematically studied 26 patients with Paget's disease severe enough to require diphosphonate therapy. Five of these patients were found to have isolated elevations of serum IgM which were well outside the normal range for their age, sex and race. An additional patient had elevations of both IgG and IgM. These patients seem to represent a subset of Pagetics. They do not differ from the remainder of the group with respect to severity or extent of disease, response to therapy, presence of intercurrent disease or age. They do have a different male to female ratio. These observations suggest that some patients with Paget's disease may have disordered immune regulation or that they may be undergoing a primary response to an agent involved in the aetiology or pathogenesis of the disease
PMCID:1535969
PMID: 6713730
ISSN: 0009-9104
CID: 99120

Gonadotropic hormone binding to human ovarian tumors

Kammerman S; Demopoulos RI; Raphael C; Ross J
A variety of normal human ovarian tissues as well as benign and malignant human ovarian neoplasms have been examined in vitro for the presence of gonadotropin binding sites and gonadotropin-stimulable cAMP production, in order to determine whether gonadotropic hormones have an effect on ovarian tumors. Binding of either FSH or hCG, or both, was demonstrated in several tumors from each of the histologic subgroups of primary ovarian tumors, including epithelial, sex cord-stromal, and germ cell types. Cyclic AMP stimulation was found in one tumor of sex cord-stromal origin, in two of epithelial origin, in two of germ cell origin, and in one tumor-like condition, pregnancy luteoma. Additional biochemical studies are needed to characterize receptor sites and to relate them to histologic features, growth behavior in vivo, and serum gonadotropin levels
PMID: 6271662
ISSN: 0046-8177
CID: 29021

Fine structural evidence on the origin of gonadotropin-induced ovarian tumors in mice

Demopoulos RI; Kammerman S
A nonluteinized granulosa cell ovarian tumor and a purely luteinized ovarian tumor, induced by gonadotropin stimulation in mice, were studied ultrastructurally to obtain evidence concerning the possible origin of these tumors, whether from granulosa cells only or from granulosa and theca. Evidence including the presence of cells sharing features of both nonluteinized and luteinized cells, the presence of desmosomes and other junctional complexes in both cell types, and the presence of partially extracted lipid droplets in the luteinized cells suggests that the luteinized cells represent granulosa-lutein cells rather than theca-lutein cells. These findings are consistent with the concept that these tumors represent a spectrum of differentiation from nonluteinized granulosa cells to luteinized granulosa cells. The lack of theca and theca-lutein cells in both tumors implies that theca cells are not involved as progenitor cells
PMID: 6257386
ISSN: 0008-5472
CID: 29024

A gonadotropin-responsive virilizing granulosa tumor [Case Report]

Wilson SJ; Young BK; Katz M; Kammerman S; Epstein J; Bigelow B
A case of a progressive virilizing solid granulosa-theca cell tumor producing high testosterone levels that were suppressed to normal by a course of oral contraceptives is presented. In vitro studies demonstrated significant specific follicle-stimulating hormone (FSH) receptors on the tumor. The studies of the biological response to gonadotropins in terms of cyclic AMP generation also indicate that the tumor is responsive to gonadotropic hormones in vitro, and are consistent with the in vivo clinical response. A discussion of the role of gonadotropins in the etiology or maintenance of ovarian tumors is also presented
PMID: 6260441
ISSN: 0196-9617
CID: 66891

Gonadotropin receptors in experimentally induced ovarian tumors in mice

Kammerman S; Demopoulos RI; Ross J
Gonadotropic hormones are required for the induction and maintenance of tumors arising in ovaries that have been transplanted to the spleens of gonadectomized mice. The characteristics of gonadotropin receptors for human chorionic gonadotropin (HCG)-luteinizing hormone on cells from these tumors of varying size, age, and morphology have been determined. The specific binding of 125I-labeled HCG to cells obtained by collagenase digestion, 15 to 65 weeks postimplantation from granulosa cell or luteinized cell, or mixed granulosa-luteal tumors was analyzed by Scatchard plot. Neither the size, weight, duration of implantation, nor histological morphology affected the receptor-binding affinity [equilibrium dissociation constant (Kd), 6 X 10(-10) M], and, presumably, the receptor is qualitatively similar. In contrast, the number of HCG receptors per cell increased 17-fold and was related to the degree of morphological luteinization of the tumor. HCG-sensitive adenyl cyclase was also demonstrated and compared to HCG binding in a highly luteinized tumor
PMID: 194683
ISSN: 0008-5472
CID: 29031