Faculty Bibliography

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Gastroenterology. 1986:90(5):1504-1504.DOI:

THE VALUE OF SURVEILLANCE BY COLONOSCOPY USED IN THE ROUTINE MANAGEMENT OF ULCERATIVE-COLITIS [Meeting Abstract]

KRUMHOLZ, MP; WOOLRICH, AJ; ROTTERDAM, HZ; KORELITZ, BI
ISI:A1986A921200741
ISSN: 0016-5085
CID: 688832
American journal of gastroenterology. 1985:80(10):864-864.DOI:

SHORT AND LONG-TERM TOXICITY TO 6-MERCAPTOPURINE IN THE MANAGEMENT OF INFLAMMATORY BOWEL-DISEASE [Meeting Abstract]

PRESENT, DH; MELTZER, SJ; KRUMHOLZ, MP; WOLKE, A; KORELITZ, BI
ISI:A1985ARW3200160
ISSN: 0002-9270
CID: 688862
Circulatory shock. 1982:9(1):1-6.DOI:

Cytosolic alpha-glycerophosphate and lactate dehydrogenase in the lung in endotoxin shock

Sayeed, M M; Krumholz, M P
The lung produces lactate aerobically. In endotoxin shock in aerobic production of lactate increases further. We have investigated an enzymic mechanism for the aerobic lactate in the lung. Since an inadequacy of the cytoplasmic hydrogen "shuttle" enzyme alpha-glycerophosphate dehydrogenase (alpha-GPDH) and/or the presence of lactate dehydrogenase (LDH) in excess of alpha-GPDH can cause aerobic formation lactate, we measured alpha-GPDH and LDH in mitochondria-free cytoplasmic fractions of lungs from control and endotoxic shock rats. The shock was induced by an intravenous injection of E coli endotoxin, 16 mg/kg. In lungs of control or endotoxic shock rats, alpha-GPDH was only 10% of the LDH activity. The low absolute levels of alpha-GPDH and the relative deficiency of this enzyme, compared to LDH in the lungs of control and endotoxic shock rats, can potentially contribute to aerobic lactate production.
PMID: 6802512
ISSN: 0092-6213
CID: 847602