Try a new search

Format these results:

Searched for:

person:levyb01

in-biosketch:yes

Total Results:

9


Implementation of Basal-Bolus Therapy in Type 2 Diabetes: A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch with an Insulin Pen

Bergenstal, Richard M; Peyrot, Mark; Dreon, Darlene M; Aroda, Vanita R; Bailey, Timothy S; Brazg, Ronald L; Frias, Juan P; Johnson, Mary L; Klonoff, David C; Kruger, Davida F; Ramtoola, Shenaz; Rosenstock, Julio; Serusclat, Pierre; Weinstock, Ruth S; Naik, Ramachandra G; Shearer, David M; Zraick, Vivien; Levy, Brian L
PMCID:6532545
PMID: 31025878
ISSN: 1557-8593
CID: 5367512

User- and Health Care Provider-Reported Outcomes for a Wearable Bolus Insulin Delivery Patch [Meeting Abstract]

Peyrot, Mark; Bergenstal, Richard M.; Dreon, Darlene M.; Aroda, Vanita; Bailey, Timothy S.; Brazg, Ronald L.; Frias, Juan P.; Johnson, Mary L.; Klonoff, David C.; Kruger, Davida F.; Ramtoola, Shenaz; Rosenstock, Julio; Serusclat, Pierre; Weinstock, Ruth S.; Naik, Ramachandra G.; Shearer, David M.; Zraick, Vivien; Levy, Brian L.
ISI:000462825102260
ISSN: 0012-1797
CID: 5367612

Optimizing Basal-Bolus Therapy in T2D-A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch vs. an Insulin Pen [Meeting Abstract]

Bergenstal, Richard M.; Peyrot, Mark; Dreon, Darlene M.; Aroda, Vanita; Bailey, Timothy S.; Brazg, Ronald L.; Frias, Juan P.; Johnson, Mary L.; Klonoff, David C.; Kruger, Davida F.; Ramtoola, Shenaz; Rosenstock, Julio; Serusclat, Pierre; Weinstock, Ruth S.; Naik, Ramachandra G.; Shearer, David M.; Zraick, Vivien; Levy, Brian L.
ISI:000462825102252
ISSN: 0012-1797
CID: 5367602

Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report

Maahs, David M; Buckingham, Bruce A; Castle, Jessica R; Cinar, Ali; Damiano, Edward R; Dassau, Eyal; DeVries, J Hans; Doyle, Francis J 3rd; Griffen, Steven C; Haidar, Ahmad; Heinemann, Lutz; Hovorka, Roman; Jones, Timothy W; Kollman, Craig; Kovatchev, Boris; Levy, Brian L; Nimri, Revital; O'Neal, David N; Philip, Moshe; Renard, Eric; Russell, Steven J; Weinzimer, Stuart A; Zisser, Howard; Lum, John W
Research on and commercial development of the artificial pancreas (AP) continue to progress rapidly, and the AP promises to become a part of clinical care. In this report, members of the JDRF Artificial Pancreas Project Consortium in collaboration with the wider AP community 1) advocate for the use of continuous glucose monitoring glucose metrics as outcome measures in AP trials, in addition to HbA1c, and 2) identify a short set of basic, easily interpreted outcome measures to be reported in AP studies whenever feasible. Consensus on a broader range of measures remains challenging; therefore, reporting of additional metrics is encouraged as appropriate for individual AP studies or study groups. Greater consistency in reporting of basic outcome measures may facilitate the interpretation of study results by investigators, regulatory bodies, health care providers, payers, and patients themselves, thereby accelerating the widespread adoption of AP technology to improve the lives of people with type 1 diabetes.
PMCID:4915553
PMID: 27330126
ISSN: 1935-5548
CID: 2157982

Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents

Rosenstock, Julio; Bergenstal, Richard; Defronzo, Ralph A; Hirsch, Irl B; Klonoff, David; Boss, Anders H; Kramer, David; Petrucci, Richard; Yu, Wen; Levy, Brian
OBJECTIVE: This double-blind, placebo-controlled, randomized, multicenter, parallel-group study compared the efficacy, safety, and tolerability of Technosphere insulin with Technosphere powder as placebo in insulin-naive type 2 diabetic patients whose diabetes was suboptimally controlled with oral antidiabetic agents. RESEARCH DESIGN AND METHODS: Patients (n = 126) were randomly assigned to 12 weeks of therapy with Technosphere insulin or Technosphere powder after lifestyle education on nutrition, exercise, and instructions on inhaler use. The primary efficacy outcome was change in A1C from baseline to study end, and the secondary efficacy outcome was area under the curve for postprandial glucose levels during a meal test at treatment weeks 4, 8, and 12. RESULTS: A1C reduction from a mean baseline of 7.9% was greater with Technosphere insulin than with Technosphere powder (-0.72 vs. -0.30%; P = 0.003). Postprandial glucose excursions were reduced by 56% with Technosphere insulin compared with baseline, and maximal postprandial glucose levels were reduced by 43% compared with Technosphere powder. Incidences of hypoglycemia, hyperglycemia, cough, and other adverse events were low in both groups. Body weight was unchanged in both groups. CONCLUSIONS: Technosphere insulin was well tolerated and demonstrated significant improvement in glycemic control with clinically meaningful reductions in A1C levels and postprandial glucose concentrations after 12 weeks of treatment.
PMCID:2571070
PMID: 18678610
ISSN: 0149-5992
CID: 1398212

Synergism between vasopressin and phorbol esters in stimulation of insulin secretion and phosphatidylcholine metabolism in RIN insulinoma cells

Monaco ME; Levy BL; Richardson SB
The tumor promoter, tetradecanoylphorbolacetate (TPA), causes a significant increase in both insulin secretion and the incorporation of 32Pi into phosphatidylcholine (PC) in RIN insulinoma cells. The peptide hormone, arginine vasopressin (AVP), also stimulates these functions, although to a lesser degree. When added together, the effects on secretion and PC metabolism are synergistic. At the same time, TPA inhibits the AVP-stimulated rise in phosphoinositide (PI) metabolism. Neither phloretin nor tamoxifen, reported to be inhibitors of protein kinase C activity, are able to block the effects of TPA on secretion, although both influence PC metabolism
PMID: 2831902
ISSN: 0006-291x
CID: 11153

Hypogonadotropic hypogonadism and delayed puberty in a man with anorexia nervosa [Case Report]

Russ, M J; Ackerman, S H; Barakat, R; Levy, B
PMID: 3774947
ISSN: 0033-3182
CID: 848612

Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome

Greene LW; Cole W; Levy B; Louie E; Raphael B; Waitkevicz HJ; Blum M
ORIGINAL:0004569
ISSN: 0084-3741
CID: 36582

Adrenal insufficiency as a complication of the acquired immunodeficiency syndrome

Greene LW; Cole W; Greene JB; Levy B; Louie E; Raphael B; Waitkevicz J; Blum M
PMID: 6089635
ISSN: 0003-4819
CID: 36564