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National Association of Medical Examiners position paper: Recommendations for the investigation and certification of deaths in people with epilepsy

Middleton, Owen; Atherton, Daniel; Bundock, Elizabeth; Donner, Elizabeth; Friedman, Daniel; Hesdorffer, Dale; Jarrell, Heather; McCrillis, Aileen; Mena, Othon J; Morey, Mitchel; Thurman, David; Tian, Niu; Tomson, Torbjörn; Tseng, Zian; White, Steven; Wright, Cyndi; Devinsky, Orrin
Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilepsy as a cause of or contributor to death. Thus it is likely that death certificates significantly underrepresent the true number of deaths in which epilepsy was a factor. To address this, members of the National Association of Medical Examiners, North American SUDEP Registry, Epilepsy Foundation SUDEP Institute, American Epilepsy Society, and the Centers for Disease Control and Prevention constituted an expert panel to generate evidence-based recommendations for the practice of death investigation and autopsy, toxicological analysis, interpretation of autopsy and toxicology findings, and death certification to improve the precision of death certificate data available for public health surveillance of epilepsy-related deaths. The recommendations provided in this paper are intended to assist medical examiners, coroners, and death investigators when a sudden unexpected death in a person with epilepsy is encountered.
PMCID:6084455
PMID: 29492970
ISSN: 1528-1167
CID: 2965612

National Association of Medical Examiners Position Paper: Recommendations for the Investigation and Certification of Deaths in People with Epilepsy

Middleton, Owen L; Atherton, Daniel S; Bundock, Elizabeth A; Donner, Elizabeth; Friedman, Daniel; Hesdorffer, Dale C; Jarrell, Heather S; McCrillis, Aileen M; Mena, Othon J; Morey, Mitchel; Thurman, David J; Tian, Niu; Tomson, Torbjörn; Tseng, Zian H; White, Steven; Wright, Cyndi; Devinsky, Orrin
Sudden unexpected death of an individual with epilepsy (SUDEP) can pose a challenge to death investigators, as most deaths are unwitnessed and the individual is commonly found dead in bed. Anatomic findings (e.g., tongue/lip bite) are commonly absent and of varying specificity, limiting the evidence to implicate epilepsy as a cause of or contributor to death. Thus, it is likely that death certificates significantly underrepresent the true number of deaths in which epilepsy was a factor. To address this, members of the National Association of Medical Examiners, North American SUDEP Registry, Epilepsy Foundation SUDEP Institute, American Epilepsy Society, and the Centers for Disease Control and Prevention convened an expert panel to generate evidence-based recommendations for the practice of death investigation and autopsy, toxicological analysis, interpretation of autopsy and toxicology findings, and death certification to improve the precision of death certificate data available for public health surveillance of epilepsy-related deaths. The recommendations provided in this paper are intended to assist medical examiners, coroners, and death investigators when a sudden, unexpected death in a person with epilepsy is encountered.
PMCID:6474453
PMID: 31240030
ISSN: 1925-3621
CID: 3954052

Mental health stigma and barriers to mental health care for first responders: A systematic review and meta-analysis

Haugen, Peter T; McCrillis, Aileen M; Smid, Geert E; Nijdam, Mirjam J
OBJECTIVE: It is unclear how many first responders experience barriers to care and stigma regarding mental health care, and how this influences their help-seeking. A systematic review and meta-analysis was conducted on barriers to care and mental health stigma in first responders and their empirical relationship with psychosocial and psychiatric variables. METHODS: The databases Medline, Embase PsycINFO, CINAHL, PILOTS, LILACS, Sociological Abstracts, SocINDEX, and Social Citation Index were searched to identify relevant studies. A quality assessment and meta-analysis was performed. RESULTS: Fourteen articles met inclusion criteria, from which data from 12 samples were extracted for meta-analyses. All studies measured stigma regarding mental health care and 33.1% of first responders (95% CI 26.7-40.1; 12 individual samples) endorsed stigma items. The systematic review revealed that the most frequently endorsed items were fears regarding confidentiality and negative career impact. Five of 14 studies measured barriers to mental health care and 9.3% of first responders (95% CI 7.0-12.3; 4 individual samples) endorsed barriers to care items. The most frequently endorsed barriers were scheduling concerns and not knowing where to get help. Indications were found for more stigma and barriers in individuals with mental health problems. CONCLUSIONS: Stigma and barriers to care are experienced by a significant proportion of firs responders, which can potentially lead to delayed presentation in mental health care and therefore, increased risk of chronicity of post-trauma psychopathology for these groups. The current systematic review draws attention to the paucity of research in this area, particularly in non-Western samples.
PMID: 28800529
ISSN: 1879-1379
CID: 2664252

Collaboration challenges in systematic reviews: a survey of health sciences librarians

Nicholson, Joey; McCrillis, Aileen; Williams, Jeff D
OBJECTIVE:While many librarians have been asked to participate in systematic reviews with researchers, often these researchers are not familiar with the systematic review process or the appropriate role for librarians. The purpose of this study was to identify the challenges and barriers that librarians face when collaborating on systematic reviews. To take a wider view of the whole process of collaborating on systematic reviews, the authors deliberately focused on interpersonal and methodological issues other than searching itself. METHODS:To characterize the biggest challenges that librarians face while collaborating on systematic review projects, we used a web-based survey. The thirteen-item survey included seventeen challenges grouped into two categories: methodological and interpersonal. Participants were required to indicate the frequency and difficulty of the challenges listed. Open-ended questions allowed survey participants to describe challenges not listed in the survey and to describe strategies used to overcome challenges. RESULTS:Of the 17 challenges listed in the survey, 8 were reported as common by over 40% of respondents. These included methodological issues around having too broad or narrow research questions, lacking eligibility criteria, having unclear research questions, and not following established methods. The remaining challenges were interpersonal, including issues around student-led projects and the size of the research team. Of the top 8 most frequent challenges, 5 were also ranked as most difficult to handle. Open-ended responses underscored many of the challenges included in the survey and revealed several additional challenges. CONCLUSIONS:These results suggest that the most frequent and challenging issues relate to development of the research question and general communication with team members. Clear protocols for collaboration on systematic reviews, as well as a culture of mentorship, can help librarians prevent and address these challenges.
PMCID:5624428
PMID: 28983202
ISSN: 1558-9439
CID: 2909412

Seeing the Big Picture Through Smaller Screens: Characterizing the Library Users' Experience on Mobile Devices

McCrillis, Aileen; Piazza, Allison; Larson, Catherine
Mobile devices are becoming profoundly important tools for finding and accessing information in medicine; however, accessing institution-licensed content on mobile devices can be problematic. An assessment was performed of selected library systems, publisher platforms, and licensed information resources for compatibility with several types of smartphones and tablets. The majority of products assessed had some form of mobile compatibility, but mobile compatibility varied among product categories and the form of mobile compatibility varied among products. This assessment reveals that users of academic health sciences libraries may have an incongruent user experience on mobile devices due to the diversity of digital platforms.
SCOPUS:85029902297
ISSN: 1542-4065
CID: 2769022

Pulmonary and cardiac pathology in sudden unexpected death in epilepsy (SUDEP)

Nascimento, Fabio A; Tseng, Zian H; Palmiere, Cristian; Maleszewski, Joseph J; Shiomi, Takayuki; McCrillis, Aileen; Devinsky, Orrin
OBJECTIVE: To review studies on structural pulmonary and cardiac changes in SUDEP cases as well as studies showing pulmonary or cardiac structural changes in living epilepsy patients. METHODS: We conducted electronic literature searches using the PubMed database for articles published in English, regardless of publication year, that included data on cardiac and/or pulmonary structural abnormalities in SUDEP cases or in living epilepsy patients during the postictal period. RESULTS: Fourteen postmortem studies reported pulmonary findings in SUDEP cases. Two focused mainly on assessing lung weights in SUDEP cases versus controls; no group difference were found. The other 12 reported descriptive autopsy findings. Among all SUDEP cases with available descriptive postmortem pulmonary examination, 72% had pulmonary changes, most often pulmonary edema/congestion, and, less frequently, intraalveolar hemorrhage. Eleven studies reported on cardiac pathology in SUDEP. Cardiac abnormalities were found in approximately one-fourth of cases. The most common findings were myocyte hypertrophy and myocardial fibrosis of various degrees. Among living epilepsy patients, postictal pulmonary pathology was the most commonly reported pulmonary abnormality and the most common postictal cardiac abnormality was transient left ventricular dysfunction - Takotsubo or neurogenic stunned myocardium. SIGNIFICANCE: Cardiac and pulmonary pathological abnormalities are frequent among SUDEP cases, most commonly pulmonary edema/congestion and focal interstitial myocardial fibrosis. Most findings are not quantified, with subjective elements and undefined interobserver reliability, and lack of controls such as matched epilepsy patients who died from other causes. Further, studies have not systematically evaluated potential confounding factors, including postmortem interval to autopsy, paramedic resuscitation and IV fluids administration, underlying heart/lung disease, and risk factors for cardiac or pulmonary disease. Prospective studies with controls are needed to define the heart and lung changes in SUDEP and understand their potential relationship to mechanisms of death in SUDEP.
PMID: 28633090
ISSN: 1525-5069
CID: 2604272

Regional versus general anaesthesia for improved cognitive function after procedures other than cardiac surgery or neurosurgery in adult and paediatric patients

Andreae, Michael H; Atchabahian, Arthur; McCrillis, Aileen M; Chao, Jerry Y; Suzuki, Suzuko; Shinnar, Shlomo; Hall, Charles B; Lipton, Richard B
This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this review is to compare the effects of regional versus general anaesthesia on cognitive function after procedures other than cardiac surgery or neurosurgery in adult and in paediatric patients.
PMCID:5063242
PMID: 27746701
ISSN: 1469-493x
CID: 2279162

Starting the data conversation: informing data services at an academic health sciences library

Read, Kevin B; Surkis, Alisa; Larson, Catherine; McCrillis, Aileen; Graff, Alice; Nicholson, Joey; Xu, Juanchan
OBJECTIVE: The research obtained information to plan data-related products and services. METHODS: Biomedical researchers in an academic medical center were selected using purposive sampling and interviewed using open-ended questions based on a literature review. Interviews were conducted until saturation was achieved. RESULTS: Interview responses informed library planners about researchers' key data issues. CONCLUSIONS: This approach proved valuable for planning data management products and services and raising library visibility among clients in the research data realm.
PMCID:4511052
PMID: 26213504
ISSN: 1558-9439
CID: 1697062

Pharmacologic Androgen Deprivation and Cardiovascular Disease Risk Factors: a Systematic Review

Romo, Matthew L; McCrillis, Aileen M; Brite, Jennifer; Reales, Dalicia; Dowd, Jennifer B; Schooling, C Mary
BACKGROUND: Pharmacologic androgen deprivation therapy (ADT) is widely used to treat prostate cancer. Observational studies suggest ADT is associated with cardiovascular disease and its risk factors; however, such studies may be subject to bias. Our objective was to evaluate the effect of ADT on cardiovascular disease risk factors from randomised controlled trials (RCTs). MATERIALS AND METHODS: We conducted a systematic review using MEDLINE and MEDLINE In-Process (1950-June 2013), EMBASE (1974-June 2013), and Web of Science (1900-June 2013) for all RCTs in men with prostate cancer that compared pharmacologic ADT (i.e., use of gonadotropin-releasing hormone agonist or antagonist) with a group that did not receive ADT and reported data on cardiovascular disease risk factors including blood pressure, cholesterol, triglycerides, fibrinogen, biomarkers of insulin sensitivity, adiposity, and C-reactive protein. We also searched for on-going or unpublished trials. This study was registered at the PROSPERO International Prospective Register of Systematic Reviews (CRD42013005097). RESULTS: Out of the 3272 unique publications identified in our systematic review, we did not identify a single RCT that reported data on any cardiovascular disease risk factor. We were unable to locate unreported data from corresponding authors. CONCLUSIONS: There is a lack of published, reliable evidence describing the effects of ADT on cardiovascular disease risk factors. RCTs have likely collected data on these risk factors as part of routine study monitoring; however, these data have not been published. In order to understand the effect of ADT on cardiovascular morbidity, these data must be made available to the scientific community
PMID: 25753698
ISSN: 0014-2972
CID: 1494722

Health sciences librarians, patient contact, and secondary traumatic stress

Becker, Rachel W; McCrillis, Aileen
OBJECTIVE: The purpose of this study was to determine the prevalence of secondary traumatic stress (STS) in health sciences librarians (HSLs) who have direct contact with traumatized individuals and their families. METHODS: A twenty-five-item survey and the Secondary Traumatic Stress Scale (STSS) were distributed via email to three Medical Library Association email discussion lists. RESULTS: A total of fifty-five HSLs responded to the survey. Survey results indicate moderate levels of STS and variability of symptoms among participants. CONCLUSIONS: Library and employee assistance program managers should be aware of the emotional toll of patient and/or family contact for HSLs.
PMCID:4404861
PMID: 25918488
ISSN: 1558-9439
CID: 1645862