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229


Desquamative extravasation reaction secondary to enfortumab vedotin [Case Report]

Pulavarty, Akshay N; Meehan, Shane; Weed, Jason
PMCID:10943994
PMID: 38496727
ISSN: 2352-5126
CID: 5640082

General dermatology and dermatology in primary health care

Buontempo, Michael G; Ramachandran, Vignesh; Freedman, Jeremy; Meehan, Shane A; Lo Sicco, Kristen; Saitta, Peter A
PMID: 38504473
ISSN: 1365-2230
CID: 5640482

Subclinical persistence of residual acral melanoma in situ after treatment with topical imiquimod and retinoid creams [Case Report]

Ingrassia, Jenne P; Greenwald, Elizabeth; Meehan, Shane; Stein, Jennifer A; Liebman, Tracey N
PMCID:10876463
PMID: 38379878
ISSN: 2352-5126
CID: 5634262

Dronedarone-induced phototoxic dermatitis [Letter]

Taranto, Viktoria; Shvartsbeyn, Marianna; Meehan, Shane A; Siegel, Louis J
PMID: 37700581
ISSN: 1365-4632
CID: 5593482

A 30-Year-Old Man With Finger Pain and Swelling [Case Report]

Li-Geng, Tony; Sartori, Daniel J; Shoucri, Sherif; Meehan, Shane A; Karagounis, Theodora K
PMID: 37607354
ISSN: 1537-6591
CID: 5598412

Black Fungus of the Foot: An Unusual Presentation of COVID-19-associated Mucormycosis

Russo, Ashley T; Buffolino, Raffaella; Shvartsbeyn, Marianna; Meehan, Shane A
Mucormycosis, also known as black fungus, is a rare but aggressive fungal disease with high morbidity and mortality rates that tends to affect patients who are severely immunocompromised. Early recognition of the infection and prompt intervention is critical for treatment success. In recent years the COVID-19 pandemic has resulted in a surge in the number of cases of mucormycosis. This study aims to report an unfortunate event involving an immunocompromised elderly male with mucormycosis of the foot who expired from sepsis due to COVID-19. It is important to have a high clinical suspicion for mucormycosis when a clinical lesion develops, and to appropriately biopsy the lesion in question, particularly in a context of COVID-19. Raising awareness of COVID-19-associated mucormycosis may allow for early detection of the disease, thus enabling the initiation of rapid treatment, ultimately saving lives.
PMID: 37471290
ISSN: 1930-8264
CID: 5535982

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems

Castillo, Rochelle L; Sidhu, Ikjot; Dolgalev, Igor; Chu, Tinyi; Prystupa, Aleksandr; Subudhi, Ipsita; Yan, Di; Konieczny, Piotr; Hsieh, Brandon; Haberman, Rebecca H; Selvaraj, Shanmugapriya; Shiomi, Tomoe; Medina, Rhina; Girija, Parvathy Vasudevanpillai; Heguy, Adriana; Loomis, Cynthia A; Chiriboga, Luis; Ritchlin, Christopher; Garcia-Hernandez, Maria De La Luz; Carucci, John; Meehan, Shane A; Neimann, Andrea L; Gudjonsson, Johann E; Scher, Jose U; Naik, Shruti
Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context and systemic impact remain poorly understood. We thus profiled human psoriasis (PsO) as a prototypic immune-mediated condition with a high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses of 25 healthy, active lesion, and clinically uninvolved skin biopsies and integration with public single-cell transcriptomics data revealed marked differences in immune microniches between healthy and inflamed skin. Tissue-scale cartography further identified core disease features across all active lesions, including the emergence of an inflamed suprabasal epidermal state and the presence of B lymphocytes in lesional skin. Both lesional and distal nonlesional samples were stratified by skin disease severity and not by the presence of systemic disease. This segregation was driven by macrophage-, fibroblast-, and lymphatic-enriched spatial regions with gene signatures associated with metabolic dysfunction. Together, these findings suggest that mild and severe forms of PsO have distinct molecular features and that severe PsO may profoundly alter the cellular and metabolic composition of distal unaffected skin sites. In addition, our study provides a valuable resource for the research community to study spatial gene organization of healthy and inflamed human skin.
PMID: 37267384
ISSN: 2470-9468
CID: 5536642

Osimertinib-associated erythema dyschromicum perstans-like eruption: A case series [Case Report]

Oh, Christina S; Martinez, Michael J; Meehan, Shane; Gutierrez, Daniel; Tattersall, Ian W
PMCID:10106340
PMID: 37078012
ISSN: 2352-5126
CID: 5466262

Bictegravir-Induced Drug Reaction with Eosinophilia and Systemic Symptoms in a Patient with Acute Human Immunodeficiency Virus

DiLorenzo, Madeline A.; Medrano, Nicola; Chen, Jason N.; Bawany, Fatima; Tran, Duy C.; Taunk, Pulkit; Meehan, Shane A.; Pomeranz, Miriam Keltz; Mgbako, Ofole
Although drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with antiretrovirals, there are no published reports of bictegravir-induced DRESS. Bictegravir is recommended as first-line treatment for patients with human immunodeficiency virus (HIV). Recognition of DRESS, its skin manifestations, and potential complications is vital for appropriate care and management of acute HIV.
SCOPUS:85153510942
ISSN: 2328-8957
CID: 5461952

A rare case of pruritic papular eruption of human immunodeficiency virus in a patient without a diagnosis of acquired immunodeficiency syndrome

Belzer, Annika; Ramachandran, Vignesh; Meehan, Shane A.; Pomeranz, Miriam K.; Matatova, Marina
SCOPUS:85144920891
ISSN: 2352-5126
CID: 5407642