Try a new search

Format these results:

Searched for:

person:mue01

in-biosketch:yes

Total Results:

38


Impact of COVID-19 on melanoma diagnosis

Weston, Gillian K; Jeong, Haneol S; Mu, Euphemia W; Polsky, David; Meehan, Shane A
PMID: 33625106
ISSN: 1473-5636
CID: 4815012

Histopathologic reaction patterns to differentially cross-linked hyaluronic acid fillers: A retrospective case series

Mu, Euphemia W; Stokar, Evan; Franks, Linda; Meehan, Shane A
BACKGROUND:Hyaluronic acid (HA) filler reactions have been increasingly observed in recent years. Our study investigates whether the increased number of filler reactions observed since 2014 is associated with a specific histopathologic inflammatory pattern and type of filler. METHODS:The institution's dermatopathology electronic database was retrospectively searched for histopathologic reactions to HA from January 2014 to December 2019. The age, sex, type of filler, procedure, location, and histopathologic patterns were recorded. RESULTS:From 2014 to 2019, there were 15 cases of granulomatous reactions to HA filler. In 10 of these cases, there was a characteristic inflammatory pattern characterized by tightly cuffed palisades of histiocytes with varying numbers of eosinophils. Of the 11 cases in which the type of filler was known, all used Vycross technology, a novel manufacturing process in the production of HA filler. CONCLUSION/CONCLUSIONS:A characteristic histopathologic pattern of discrete foci of tightly cuffed palisaded granulomas with eosinophils is associated with fillers manufactured using Vycross technology.
PMID: 33350498
ISSN: 1600-0560
CID: 4771152

Learning Analytics to Enhance Dermatopathology Education Among Dermatology Residents

Mu, Euphemia W.; Pusic, Martin; Coneybeare, Matt; Meehan, Shane A.
BACKGROUND: With the advent of digital microscopy, learning analytics can be leveraged to advance teaching of dermatopathology in dermatology residency.
PMID: 31860211
ISSN: 1545-9616
CID: 5069602

Excision Recommendation Rates of Atypical (Dysplastic) Nevi Amongst Experienced Dermatopathologists

Mu, Euphemia W; Chen, Lu; Rothman, Lisa; Rubio-Gonzalez, Belen; Marks, Etan; Persad, Leah; Cockerell, Clay J; Leboit, Phil; Meehan, Shane A
Dermatologists rely on dermatopathologists to assess the need for excision of atypical melanocytic nevi.1 We observed an increase in the diagnosis of moderately and severely atypical nevi and the recommendation to excise in cases referred for a second opinion. This article is protected by copyright. All rights reserved.
PMID: 31115934
ISSN: 1600-0560
CID: 3920632

Response to "Risk of bias assessment in primary studies for the development of systematic reviews: a reflection about exposure to systemic dermatological drugs and its effects on infertility and teratogenicity in males" [Letter]

Zakhem, George A; Motosko, Catherine C; Mu, Euphemia W; Ho, Roger S
PMID: 30654081
ISSN: 1097-6787
CID: 3595402

Infertility and Teratogenicity after Paternal Exposure to Systemic Dermatologic Medications: A Systematic Review

Zakhem, George A; Motosko, Catherine C; Mu, Euphemia W; Ho, Roger S
BACKGROUND:This systematic review assesses effects of paternal exposure of dermatologic medications, using the former US Food and Drug Administration (FDA) pregnancy categories as a benchmark. OBJECTIVE:To assess whether systemic dermatologic medications can cause infertility and teratogenicity when taken by men. METHODS:Category D and X dermatologic medications were identified; a systematic review of the literature and reviews of the FDA Adverse Events Reporting System (FAERS) and prescribing information were performed to identify effects on male fertility and teratogenicity. Secondary search was performed to assess for other systemic dermatologic medications causing teratogenicity or infertility following paternal exposure. RESULTS:Thirteen medications met inclusion criteria. Nineteen of 1,032 studies were included after systematic review of the literature. Studies evaluating medication effects with paternal exposure were identified for 10 of 13 evaluated medications, and evidence of a negative effect was identified for 6 medications. LIMITATIONS/CONCLUSIONS:We did not encounter any studies for 3 medications that met inclusion criteria. Information submitted to the FAERS may not reflect incidence of side effects. CONCLUSIONS:Many former pregnancy category D and X systemic dermatologic medications also have effects on male fertility. More research and better-quality studies are required in this area, particularly assessing potential teratogenicity.
PMID: 30287313
ISSN: 1097-6787
CID: 3329312

55-year-old man with ulcers in inguinal fold and intergluteal cleft found to have systemic Langerhans cell histiocytosis

Mu, Euphemia W; Khurram, Nigar Anjuman; Pei, Zhiheng; Feng, Hao; Cassai, Nicholas; Meehan, Shane A; Latkowski, Jo-Ann
PMCID:6143693
PMID: 30238052
ISSN: 2352-5126
CID: 3293072

Margin Assessment for Punch and Shave Biopsies of Dysplastic Nevi

Zakhem, George A; Terushkin, Vitaly; Mu, Euphemia W; Polsky, David; Meehan, Shane A
INTRODUCTION/BACKGROUND:Biopsies of atypical melanocytic nevi are among the most commonly performed procedures by dermatologists. Margin assessment is often used to guide re-excision, but can be a point of confusion as negative margins reported in the planes of sections examined do not always reflect complete removal of a lesion. This study investigates the rates of false negative margins after both punch and shave biopsies. METHODS:We performed a retrospective analysis of 50 consecutive punch and shave biopsy specimens (1) diagnosed as DN, and (2) reported as having clear margins in the planes of section examined. Identified specimen blocks were then sectioned through to examine true margin involvement. RESULTS:Of the 50 specimens identified, 20% (n = 10) were found to have positive margins upon additional sectioning. We found no difference between the groups with respect to biopsy technique, type of nevus, degree of atypia, or gender. CONCLUSION/CONCLUSIONS:This study observed false negative peripheral margin status in a sizeable proportion of biopsy specimens, which did not vary significantly based on biopsy technique or pathologic characteristics. This finding reflects a limitation of standard tissue processing, in which a limited proportion of the true margin is evaluated, and may be of note to many dermatologists who base their decision to re-excise on the reporting of margin involvement. J Drugs Dermatol. 2018;17(7):810-812.
PMID: 30005107
ISSN: 1545-9616
CID: 3200322

Evaluation of MITF, SOX10, MART-1, and R21 Immunostaining for the Diagnosis of Residual Melanoma In Situ on Chronically Sun-Damaged Skin

Mu, Euphemia W; Quatrano, Nicola A; Yagerman, Sarah E; Ratner, Desiree; Meehan, Shane A
BACKGROUND:Melanocytic immunostains can assist in margin evaluation of melanoma in situ (MIS) excisions; however, their accuracy and reliability relative to hematoxylin & eosin (H&E) is yet to be determined. OBJECTIVE:The objective of this study was to evaluate the sensitivity, specificity, and concordance of 4 melanocyte-specific immunostains for diagnosing MIS occurring on chronically sun-damaged skin. MATERIALS AND METHODS/METHODS:Serial permanent sections from representative areas of negative margin and residual tumor were stained using H&E, MITF, MART-1, SOX10, and R21 and examined in a blinded fashion. The study set included 100 digital microscopy images from 10 cases of MIS excisions from the face. Two board-certified dermatopathologists, 4 fellowship-trained Mohs surgeons, 2 Mohs fellows, and 2 dermatology residents independently reviewed the 100 images. RESULTS:The average melanocyte density was 11 versus 28 melanocytes per 0.5 mm for chronically sun-damaged skin versus residual MIS on H&E, respectively. Statistically significantly higher melanocyte densities were observed using MITF, MART-1, and SOX10 on negative margins. The sensitivity and interobserver concordance was highest using MITF and SOX10. The intraobserver agreement on 4 duplicate images was 85%. CONCLUSION/CONCLUSIONS:In conclusion, the nuclear immunostains (MITF and SOX10) show the most promise for improving the diagnosis of MIS in chronically sun-damaged skin.
PMID: 29419543
ISSN: 1524-4725
CID: 2948252

Demographic and Tumor Characteristics of Patients Younger Than 50 Years With Nonmelanoma Skin Cancer Referred for Mohs Micrographic Surgery

Quatrano, Nicola A; Mu, Euphemia W; Orbuch, David E; Haimovic, Adele; Geronemus, Roy G; Brauer, Jeremy A
BACKGROUND:An increase in nonmelanoma skin cancer (NMSC) in younger patients has been reported. Many are treated with Mohs micrographic surgery (MMS). OBJECTIVE:Investigate patient and tumor characteristics in patients less than 50 years undergoing MMS for NMSC at a large, referral-based practice. METHODS & MATERIALS/METHODS:Retrospective chart review of 1,332 tumors occurring in 1,018 consecutive patients over a five-year period. RESULTS:81.7% of tumors were BCC and 55.3% occurred in women. Patients less than 30 years were more likely to be female (P equals 0.016) and women were more likely to have BCC (P equals 0.010). SCCs were more likely with increasing age (P less than 0.001). Of all tumors, 3.6% were recurrent, 2.7% had diameters ≥ 2 centimeters, and 5.5% of all BCCs had a high-risk histologic subtype. Women were more than twice as likely as men to be referred to plastic surgery for repair (P equals 0.020). CONCLUSION/CONCLUSIONS:Patients < 50 years with NMSC may represent a growing population referred for MMS, especially young women with BCC. High-risk tumor features were rare among young patients, and female gender was associated with an increased rate of referral for repair by a plastics subspecialty. Study was performed at the Laser & Skin Surgery Center of New York. IRB STATUS/UNASSIGNED:Approved by Essex Institutional Review Board, Protocol #MOHS40-65 <p><em>J Drugs Dermatol. 2018;17(5):499-505.</em></p>.
PMID: 29742179
ISSN: 1545-9616
CID: 3164092