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128


Update on estrogen therapy and prevention of bone loss [Comment]

Nachtigall, Margaret; Nachtigall, Lila
PMID: 37192835
ISSN: 1530-0374
CID: 5536542

Hormone Therapy for the Prevention of Chronic Conditions in Postmenopausal Persons [Comment]

Nachtigall, Margaret; Nachtigall, Richard; Nachtigall, Lila
PMID: 36943220
ISSN: 1538-3598
CID: 5449142

Letter to the Editor [Comment]

Nachtigall, Margaret J; Nachtigall, Lila E; Nachtigall, Richard H
PMID: 33973542
ISSN: 1530-0374
CID: 4878322

Patient Satisfaction With the Use of Revaree to Treat Vaginal Atrophy Symptoms [Meeting Abstract]

Nachtigall, Lila; Sylla, Sarah; Veledar, Emir; Komorowski, James
ISI:000594858400101
ISSN: 1072-3714
CID: 4729422

Menopause and the gastrointestinal system: our gut feelings

Nachtigall, Lila E; Nachtigall, Lisa
PMID: 30839365
ISSN: 1530-0374
CID: 3724032

Cardiovascular health and the menopausal woman: the role of estrogen and when to begin and end hormone treatment

Naftolin, Frederick; Friedenthal, Jenna; Nachtigall, Richard; Nachtigall, Lila
Reports have correlated the use of estrogen for the treatment of menopausal symptoms with beneficial effects on the cardiovascular system. Molecular, biochemical, preclinical, and clinical studies have furnished a wealth of evidence in support of this outcome of estrogen action. The prospective randomized Women's Health Initiative (WHI) and the Early Versus Late Intervention Trial (ELITE) showed that starting menopausal hormone treatment (MHT) within 5 to 10 years of menopause is fundamental to the success of estrogen's cardioprotection in post-menopausal women without adverse effects. Age stratification of the WHI data has shown that starting hormone treatment within the first decade after menopause is both safe and effective, and the long-term WHI follow-up studies are supportive of cardioprotection. This is especially true in estrogen-treated women who underwent surgical menopause. A critique of the WHI and other relevant studies is presented, supporting that the timely use of estrogens protects against age- and hormone-related cardiovascular complications. Salutary long-term hormone treatment for menopausal symptoms and prevention of complications has been widely reported, but there are no prospective trials defining the correct length to continue MHT. At present, women undergoing premature menopause receive estrogen treatment (ET) until evidence of hormone-related complications intervenes. Normal women started on MHT who receive treatment for decades without hormone-related complications have been reported, and the WHI follow-up studies are promising of long-term post-treatment cardioprotection. A prevention-based holistic approach is proposed for timely and continuing MHT/ET administration as part of the general management of the menopausal woman. But this should be undertaken only with scheduled, annual patient visits including evaluations of cardiovascular status. Because of the continued occurrence of reproductive cancers well into older ages, these visits should include genital and breast cancer screening.
PMCID:6733383
PMID: 31543950
ISSN: 2046-1402
CID: 4105312

Changes in an office practice of menopause in the last 25 years

Nachtigall, Lila
PMID: 29570561
ISSN: 1530-0374
CID: 3001572

Contemporary Hormonal Contraception and the Risk of Breast Cancer [Comment]

Nachtigall, Lila; Naftolin, Frederick; Keefe, David L
PMID: 29595938
ISSN: 1533-4406
CID: 3025942

Cervical cancer in an urban academic institution: Analysis of an at-risk patient population [Meeting Abstract]

Escobar, C; Kim, S H; Friedenthal, J; Ringel, N; Honart, A W; Oviedo, J; Brandon, C; Foley, C; Musselman, K; Frey, M K; Mehta-Lee, S; Blank, S V; Nachtigall, L E
Objective: While the incidence of cervical cancer has declined in the United States, cervical cancer continues to be a significant source of morbidity and mortality among specific subsets of women. In a recent study published in Cancer, black women over the age of 85[1] were found to have the greatest mortality from cervical cancer. Importantly, cervical cancer screening guidelines do not extend to this age group, highlighting the importance of gaining a comprehensive understanding of these at risk populations. The objective of this study was to define the characteristics, risk factors and clinical course of patients treated for cervical cancer at a large urban public hospital. [1] Beavis, AL, Gravitt, P Rositch, A, Hysterectomy Corrected Cervical Cancer Mortality Rates;Cancer:2017:-1044-50. Design: A review of patients treated for cervical cancer by gynecologic oncologists at Bellevue Hospital between 2007- 2015. Results: One-hundred and fifty-nine patients were treated for cervical cancer by gynecologic oncologists at an urban academic institution during the specified time period. The median age at diagnosis was 51 years (range 28- 80), with 26 (16.4%) patients over 65 years. Sixty-nine (43.4%) patients identified as Hispanic or Latina, 36 (22.6%) as Black or African-American, 25 (15.7%) as Asian, 17 (10.7%) as Caucasian, and 12 (7.5%) were unknown. Seventy-six (47.8%) patients originated from the United States, while 57 (36%) patients reported their region of origin elsewhere - 24 (15.1%) from Asia, 16 (10.1%) South America, 5 (3.1%) Africa, 12 (7.5%) Europe, and 26 (16.4%) were unknown. The vast majority of patients had public insurance (71.1%), or were uninsured (20.8%). One hundred and seven (67%) patients presented with stage IB2 or higher disease, and the predominant stage at diagnosis was IIB (40, 24.2%). Only 34 (21.4%) patients had a known history of dysplasia, with HSIL being the most common cervical cytology prior to diagnosis. Forty-two (26.4%) patients were smokers, only 1 (0.6%) patient was HIV positive on antiretroviral therapy, and 5 (3.1%) had a history of radiation or chemotherapy from a prior cancer diagnosis. One hundred and eighteen (74.2%) underwent chemotherapy and radiation, while 55 (34.6%) were treated surgically, and 3 (1.9%) did not undergo treatment. At the most recent encounter, 85 (53.5%) patients had no evidence of disease, 67 (42.1%) were alive with disease, and 6 (3.8%) had died of their disease. Conclusion: Despite advances in detection and treatment, cervical cancer remains a significant women's health care issue among at-risk patient populations in the United States. These findings draw attention to how the new screening guidelines may affect the care of women over 65 years of age
EMBASE:620232562
ISSN: 1530-0374
CID: 2930342

Work stress and menopausal symptoms

Nachtigall, Lila E
PMID: 27977502
ISSN: 1530-0374
CID: 2363602