Faculty Bibliography

Leukocyte recruitment into inflamed tissue is highly dependent on the activation and binding of integrins to their respective ligands, followed by the induction of various signaling events within the cell referred to as outside-in signaling. Src family kinases are the central players in the outside-in signaling process, assigning them a critical role for proper immune cell function. Our study investigated the role of SFKs on neutrophil recruitment in vivo using Hck-/- Fgr-/- Lyn-/- mice, which lack SFKs expressed in neutrophils. We show that loss of SFKs strongly reduces neutrophil adhesion and post-arrest modifications in a shear force dependent manner. Additionally, we found that in the absence of SFKs, neutrophils display impaired Rab27a-dependent surface mobilization of neutrophil elastase, VLA3 and VLA6 containing vesicles. This results in a defect in neutrophil vascular basement membrane penetration and thus strongly impaired extravasation. Taken together, we demonstrate a role of SFKs in neutrophil post-arrest modifications and extravasation during acute inflammation. These findings may support the current efforts to use SFK-inhibitors in inflammatory diseases with unwanted neutrophil recruitment.

Eight patients had posterior cervical spine fusion utilizing the principle of tension band fixation. Six patients with associated neurologic symptoms improved postoperatively. Solid fusion was achieved and a functional range of motion of the cervical spine was maintained in all of the living patients

A preliminary report evaluating the role of the distal fibula as the lateral supporting structure of the ankle is presented. The study involved loading the knee of an above the knee amputation specimen and recording the resultant strains on the distal fibula. This was done with the ankle of the specimen in neutral, dorsiflexion, and eversion. Results show the susceptibility of the lateral fibula to compressive strains, with the greatest compression noted when the ankle is in eversion. Early findings also indicate that the fibula and lateral malleolus play an insignificant role in the weightbearing process in the lower limb

Two case reports illustrate why it is necessary to rule out substances such as lead-based paints or ointments containing metals that may be superficially on the patient's skin at the site of a possible foreign body

For the child's comfort and to facilitate nursing care, placement of the supporting strut on a hip spica is posterior for the male and anterior for the female