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A first radiotherapy application of functional bulboclitoris anatomy, a novel female sexual organ-at-risk, and organ-sparing feasibility study

Marshall, Deborah C; Ghiassi-Nejad, Zahra; Powers, Allison; Reidenberg, Joy S; Argiriadi, Pamela; Ru, Meng; Dumane, Vishruta; Buckstein, Michael; Goodman, Karyn; Blank, Stephanie V; Schnur, Julie; Rosenstein, Barry
OBJECTIVE/UNASSIGNED:external genitalia; and, compare bulboclitoris-sparing IMRT (BCS-IMRT) to standard IMRT (S-IMRT) to determine reoptimization feasibility. METHODS/UNASSIGNED:S-IMRT. RESULTS/UNASSIGNED:Bulboclitoris structure, function and delineation are described herein. The bulboclitoris occupies 20cc (IQR:12-24), largely distinct from the external genitalia (DSC <0.05). BCS-IMRT was superior to S-IMRT in reducing the dose to the bulboclitoris, with the greatest reductions in V30 and V40, with no significant changes in dose to other OARs or PTV 1/V95. CONCLUSION/UNASSIGNED:The bulboclitoris can be contoured on planning imaging, largely distinct from the external genitalia. Compared with S-IMRT, BCS-IMRT dramatically reduced dose to the bulboclitoris in anal cancer planning. BCS-IMRT might safely reduce sexual toxicity compared with standard approaches. ADVANCES IN KNOWLEDGE/UNASSIGNED:The structure and function of the bulboclitoris, the critical primary organ responsible for female sexual arousal and orgasm, has yet to be described in the radiotherapy literature. Structure, function and delineation of the bulboclitoris are detailed, delineation and bulboclitoris-sparing IMRT were feasible, and sparing reduces the dose to the bulboclitoris nearly in half in female patients receiving IMRT for anal cancer, warranting further clinical study.
PMID: 34192475
ISSN: 1748-880x
CID: 4926702

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Conti, David V; Darst, Burcu F; Moss, Lilit C; Saunders, Edward J; Sheng, Xin; Chou, Alisha; Schumacher, Fredrick R; Olama, Ali Amin Al; Benlloch, Sara; Dadaev, Tokhir; Brook, Mark N; Sahimi, Ali; Hoffmann, Thomas J; Takahashi, Atushi; Matsuda, Koichi; Momozawa, Yukihide; Fujita, Masashi; Muir, Kenneth; Lophatananon, Artitaya; Wan, Peggy; Le Marchand, Loic; Wilkens, Lynne R; Stevens, Victoria L; Gapstur, Susan M; Carter, Brian D; Schleutker, Johanna; Tammela, Teuvo L J; Sipeky, Csilla; Auvinen, Anssi; Giles, Graham G; Southey, Melissa C; MacInnis, Robert J; Cybulski, Cezary; WokoÅ‚orczyk, Dominika; LubiÅ„ski, Jan; Neal, David E; Donovan, Jenny L; Hamdy, Freddie C; Martin, Richard M; Nordestgaard, Børge G; Nielsen, Sune F; Weischer, Maren; Bojesen, Stig E; Røder, Martin Andreas; Iversen, Peter; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Horvath, Lisa; Clements, Judith A; Tilley, Wayne; Risbridger, Gail P; Gronberg, Henrik; Aly, Markus; Szulkin, Robert; Eklund, Martin; Nordström, Tobias; Pashayan, Nora; Dunning, Alison M; Ghoussaini, Maya; Travis, Ruth C; Key, Tim J; Riboli, Elio; Park, Jong Y; Sellers, Thomas A; Lin, Hui-Yi; Albanes, Demetrius; Weinstein, Stephanie J; Mucci, Lorelei A; Giovannucci, Edward; Lindstrom, Sara; Kraft, Peter; Hunter, David J; Penney, Kathryn L; Turman, Constance; Tangen, Catherine M; Goodman, Phyllis J; Thompson, Ian M; Hamilton, Robert J; Fleshner, Neil E; Finelli, Antonio; Parent, Marie-Élise; Stanford, Janet L; Ostrander, Elaine A; Geybels, Milan S; Koutros, Stella; Freeman, Laura E Beane; Stampfer, Meir; Wolk, Alicja; HÃ¥kansson, Niclas; Andriole, Gerald L; Hoover, Robert N; Machiela, Mitchell J; Sørensen, Karina Dalsgaard; Borre, Michael; Blot, William J; Zheng, Wei; Yeboah, Edward D; Mensah, James E; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Wu, Yudong; Zhao, Shan-Chao; Sun, Zan; Thibodeau, Stephen N; McDonnell, Shannon K; Schaid, Daniel J; West, Catharine M L; Burnet, Neil; Barnett, Gill; Maier, Christiane; Schnoeller, Thomas; Luedeke, Manuel; Kibel, Adam S; Drake, Bettina F; Cussenot, Olivier; Cancel-Tassin, Géraldine; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; John, Esther M; Grindedal, Eli Marie; Maehle, Lovise; Khaw, Kay-Tee; Ingles, Sue A; Stern, Mariana C; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Rosenstein, Barry S; Kerns, Sarah L; Ostrer, Harry; Teixeira, Manuel R; Paulo, Paula; Brandão, Andreia; Watya, Stephen; Lubwama, Alexander; Bensen, Jeannette T; Fontham, Elizabeth T H; Mohler, James; Taylor, Jack A; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Cannon-Albright, Lisa; Teerlink, Craig C; Huff, Chad D; Strom, Sara S; Multigner, Luc; Blanchet, Pascal; Brureau, Laurent; Kaneva, Radka; Slavov, Chavdar; Mitev, Vanio; Leach, Robin J; Weaver, Brandi; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Saum, Kai-Uwe; Klein, Eric A; Hsing, Ann W; Kittles, Rick A; Murphy, Adam B; Logothetis, Christopher J; Kim, Jeri; Neuhausen, Susan L; Steele, Linda; Ding, Yuan Chun; Isaacs, William B; Nemesure, Barbara; Hennis, Anselm J M; Carpten, John; Pandha, Hardev; Michael, Agnieszka; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Xu, Jianfeng; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Newcomb, Lisa F; Lin, Daniel W; Fowke, Jay H; Neslund-Dudas, Christine; Rybicki, Benjamin A; Gamulin, Marija; Lessel, Davor; Kulis, Tomislav; Usmani, Nawaid; Singhal, Sandeep; Parliament, Matthew; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Larkin, Samantha; Townsend, Paul A; Aukim-Hastie, Claire; Bush, William S; Aldrich, Melinda C; Crawford, Dana C; Srivastava, Shiv; Cullen, Jennifer C; Petrovics, Gyorgy; Casey, Graham; Roobol, Monique J; Jenster, Guido; van Schaik, Ron H N; Hu, Jennifer J; Sanderson, Maureen; Varma, Rohit; McKean-Cowdin, Roberta; Torres, Mina; Mancuso, Nicholas; Berndt, Sonja I; Van Den Eeden, Stephen K; Easton, Douglas F; Chanock, Stephen J; Cook, Michael B; Wiklund, Fredrik; Nakagawa, Hidewaki; Witte, John S; Eeles, Rosalind A; Kote-Jarai, Zsofia; Haiman, Christopher A
PMID: 33473200
ISSN: 1546-1718
CID: 4760682

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Huynh-Le, Minh-Phuong; Fan, Chun Chieh; Karunamuni, Roshan; Thompson, Wesley K; Martinez, Maria Elena; Eeles, Rosalind A; Kote-Jarai, Zsofia; Muir, Kenneth; Schleutker, Johanna; Pashayan, Nora; Batra, Jyotsna; Grönberg, Henrik; Neal, David E; Donovan, Jenny L; Hamdy, Freddie C; Martin, Richard M; Nielsen, Sune F; Nordestgaard, Børge G; Wiklund, Fredrik; Tangen, Catherine M; Giles, Graham G; Wolk, Alicja; Albanes, Demetrius; Travis, Ruth C; Blot, William J; Zheng, Wei; Sanderson, Maureen; Stanford, Janet L; Mucci, Lorelei A; West, Catharine M L; Kibel, Adam S; Cussenot, Olivier; Berndt, Sonja I; Koutros, Stella; Sørensen, Karina Dalsgaard; Cybulski, Cezary; Grindedal, Eli Marie; Menegaux, Florence; Khaw, Kay-Tee; Park, Jong Y; Ingles, Sue A; Maier, Christiane; Hamilton, Robert J; Thibodeau, Stephen N; Rosenstein, Barry S; Lu, Yong-Jie; Watya, Stephen; Vega, Ana; Kogevinas, Manolis; Penney, Kathryn L; Huff, Chad; Teixeira, Manuel R; Multigner, Luc; Leach, Robin J; Cannon-Albright, Lisa; Brenner, Hermann; John, Esther M; Kaneva, Radka; Logothetis, Christopher J; Neuhausen, Susan L; De Ruyck, Kim; Pandha, Hardev; Razack, Azad; Newcomb, Lisa F; Fowke, Jay H; Gamulin, Marija; Usmani, Nawaid; Claessens, Frank; Gago-Dominguez, Manuela; Townsend, Paul A; Bush, William S; Roobol, Monique J; Parent, Marie-Élise; Hu, Jennifer J; Mills, Ian G; Andreassen, Ole A; Dale, Anders M; Seibert, Tyler M
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
PMID: 33623038
ISSN: 2041-1723
CID: 4806822

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Conti, David V; Darst, Burcu F; Moss, Lilit C; Saunders, Edward J; Sheng, Xin; Chou, Alisha; Schumacher, Fredrick R; Olama, Ali Amin Al; Benlloch, Sara; Dadaev, Tokhir; Brook, Mark N; Sahimi, Ali; Hoffmann, Thomas J; Takahashi, Atushi; Matsuda, Koichi; Momozawa, Yukihide; Fujita, Masashi; Muir, Kenneth; Lophatananon, Artitaya; Wan, Peggy; Le Marchand, Loic; Wilkens, Lynne R; Stevens, Victoria L; Gapstur, Susan M; Carter, Brian D; Schleutker, Johanna; Tammela, Teuvo L J; Sipeky, Csilla; Auvinen, Anssi; Giles, Graham G; Southey, Melissa C; MacInnis, Robert J; Cybulski, Cezary; WokoÅ‚orczyk, Dominika; LubiÅ„ski, Jan; Neal, David E; Donovan, Jenny L; Hamdy, Freddie C; Martin, Richard M; Nordestgaard, Børge G; Nielsen, Sune F; Weischer, Maren; Bojesen, Stig E; Røder, Martin Andreas; Iversen, Peter; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Horvath, Lisa; Clements, Judith A; Tilley, Wayne; Risbridger, Gail P; Gronberg, Henrik; Aly, Markus; Szulkin, Robert; Eklund, Martin; Nordström, Tobias; Pashayan, Nora; Dunning, Alison M; Ghoussaini, Maya; Travis, Ruth C; Key, Tim J; Riboli, Elio; Park, Jong Y; Sellers, Thomas A; Lin, Hui-Yi; Albanes, Demetrius; Weinstein, Stephanie J; Mucci, Lorelei A; Giovannucci, Edward; Lindstrom, Sara; Kraft, Peter; Hunter, David J; Penney, Kathryn L; Turman, Constance; Tangen, Catherine M; Goodman, Phyllis J; Thompson, Ian M; Hamilton, Robert J; Fleshner, Neil E; Finelli, Antonio; Parent, Marie-Élise; Stanford, Janet L; Ostrander, Elaine A; Geybels, Milan S; Koutros, Stella; Freeman, Laura E Beane; Stampfer, Meir; Wolk, Alicja; HÃ¥kansson, Niclas; Andriole, Gerald L; Hoover, Robert N; Machiela, Mitchell J; Sørensen, Karina Dalsgaard; Borre, Michael; Blot, William J; Zheng, Wei; Yeboah, Edward D; Mensah, James E; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Wu, Yudong; Zhao, Shan-Chao; Sun, Zan; Thibodeau, Stephen N; McDonnell, Shannon K; Schaid, Daniel J; West, Catharine M L; Burnet, Neil; Barnett, Gill; Maier, Christiane; Schnoeller, Thomas; Luedeke, Manuel; Kibel, Adam S; Drake, Bettina F; Cussenot, Olivier; Cancel-Tassin, Géraldine; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; John, Esther M; Grindedal, Eli Marie; Maehle, Lovise; Khaw, Kay-Tee; Ingles, Sue A; Stern, Mariana C; Vega, Ana; Gómez-Caamaño, Antonio; Fachal, Laura; Rosenstein, Barry S; Kerns, Sarah L; Ostrer, Harry; Teixeira, Manuel R; Paulo, Paula; Brandão, Andreia; Watya, Stephen; Lubwama, Alexander; Bensen, Jeannette T; Fontham, Elizabeth T H; Mohler, James; Taylor, Jack A; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Cannon-Albright, Lisa; Teerlink, Craig C; Huff, Chad D; Strom, Sara S; Multigner, Luc; Blanchet, Pascal; Brureau, Laurent; Kaneva, Radka; Slavov, Chavdar; Mitev, Vanio; Leach, Robin J; Weaver, Brandi; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Saum, Kai-Uwe; Klein, Eric A; Hsing, Ann W; Kittles, Rick A; Murphy, Adam B; Logothetis, Christopher J; Kim, Jeri; Neuhausen, Susan L; Steele, Linda; Ding, Yuan Chun; Isaacs, William B; Nemesure, Barbara; Hennis, Anselm J M; Carpten, John; Pandha, Hardev; Michael, Agnieszka; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Xu, Jianfeng; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Newcomb, Lisa F; Lin, Daniel W; Fowke, Jay H; Neslund-Dudas, Christine; Rybicki, Benjamin A; Gamulin, Marija; Lessel, Davor; Kulis, Tomislav; Usmani, Nawaid; Singhal, Sandeep; Parliament, Matthew; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Larkin, Samantha; Townsend, Paul A; Aukim-Hastie, Claire; Bush, William S; Aldrich, Melinda C; Crawford, Dana C; Srivastava, Shiv; Cullen, Jennifer C; Petrovics, Gyorgy; Casey, Graham; Roobol, Monique J; Jenster, Guido; van Schaik, Ron H N; Hu, Jennifer J; Sanderson, Maureen; Varma, Rohit; McKean-Cowdin, Roberta; Torres, Mina; Mancuso, Nicholas; Berndt, Sonja I; Van Den Eeden, Stephen K; Easton, Douglas F; Chanock, Stephen J; Cook, Michael B; Wiklund, Fredrik; Nakagawa, Hidewaki; Witte, John S; Eeles, Rosalind A; Kote-Jarai, Zsofia; Haiman, Christopher A
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
PMID: 33398198
ISSN: 1546-1718
CID: 4738702

Survey of Radiation Oncologists to Assess Interest and Potential Use of a Genetic Test Predicting Susceptibility for the Development of Toxicities After Prostate Cancer Radiation Therapy

Collado, Kayla; Kerns, Sarah L; Diefenbach, Michael A; Peterson-Roth, Elizabeth; Koski, Raymond; Ostrer, Harry; Stock, Richard G; Mattessich, Martin; Kaplan, Paul; Rosenstein, Barry S
Purpose/UNASSIGNED:A genetic test predicting susceptibility for the development of toxicities after prostate cancer radiation therapy is in development. This test intends to help physicians with treatment decision making. Methods and Materials/UNASSIGNED:test compared responses among participants. Multivariable ordinal regression identified factors associated with anticipated adoption or nonadoption of such a genetic test by radiation oncologists. Results/UNASSIGNED:> .05). Conclusions/UNASSIGNED:Radiation oncologists who treat prostate cancer are interested in and willing to order a genetic test predictive of susceptibility to radiation therapy toxicity to aid their treatment decision making.
PMCID:7557145
PMID: 33083651
ISSN: 2452-1094
CID: 4642242

Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy

Kerns, Sarah L; Fachal, Laura; Dorling, Leila; Barnett, Gillian C; Baran, Andrea; Peterson, Derick R; Hollenberg, Michelle; Hao, Ke; Narzo, Antonio Di; Ahsen, Mehmet Eren; Pandey, Gaurav; Bentzen, Søren M; Janelsins, Michelle; Elliott, Rebecca M; Pharoah, Paul D P; Burnet, Neil G; Dearnaley, David P; Gulliford, Sarah L; Hall, Emma; Sydes, Matthew R; Aguado-Barrera, Miguel E; Gómez-Caamaño, Antonio; Carballo, Ana M; Peleteiro, Paula; Lobato-Busto, Ramón; Stock, Richard; Stone, Nelson N; Ostrer, Harry; Usmani, Nawaid; Singhal, Sandeep; Tsuji, Hiroshi; Imai, Takashi; Saito, Shiro; Eeles, Rosalind; DeRuyck, Kim; Parliament, Matthew; Dunning, Alison M; Vega, Ana; Rosenstein, Barry S; West, Catharine M L
BACKGROUND:10-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk prediction and inform functional mechanistic studies. METHODS:We conducted an individual patient data meta-analysis of six genome-wide association studies (n = 3,871) in men with European ancestry who underwent radiotherapy for prostate cancer. Radiotoxicities (increased urinary frequency, decreased urinary stream, hematuria, rectal bleeding) were graded prospectively. Grouped relative risk models tested associations with ∼6 million genotyped/imputed variants (time to first ≥grade 2 toxicity event). Variants with two-sided Pmeta<5x10-8 were considered statistically significant. Bayesian false discovery probability provided an additional measure of confidence. Statistically significant variants were evaluated in three Japanese cohorts (n = 962). All statistical tests were two-sided. RESULTS:Meta-analysis of the European ancestry cohorts identified three genomic signals: single nucleotide polymorphism (SNP) rs17055178 with rectal bleeding (Pmeta=6.2x10-10), rs10969913 with decreased urinary stream (Pmeta=2.9x10-10) and rs11122573 with hematuria (Pmeta=1.8x10-8). Fine scale mapping of these three regions identified another independent signal (rs147121532) associated with hematuria (Pconditional=4.7x10-6). Credible causal variants at these four signals lie in gene-regulatory regions, some modulating expression of nearby genes. Previously identified variants showed consistent associations (rs17599026 with increased urinary frequency, rs7720298 with decreased urinary stream, rs1801516 with overall toxicity) in new cohorts. rs10969913 and rs17599026 had similar effects in the photon-treated Japanese cohorts. CONCLUSIONS:This study increases understanding of the architecture of common genetic variants affecting radiotoxicity, points to novel radio-pathogenic mechanisms, and develops risk models for testing in clinical studies. Further multi-national radiogenomics studies in larger cohorts are worthwhile.
PMID: 31095341
ISSN: 1460-2105
CID: 3919922

Use of genomics to balance cure and complications [Comment]

Azria, David; Rosenstein, Barry S
PMID: 31784674
ISSN: 1759-4782
CID: 4485702

The implications of genetic testing on radiotherapy decisions: a guide for radiation oncologists

Bergom, Carmen; West, Catharine M; Higginson, Daniel S; Abazeed, Mohamed E; Arun, Banu; Bentzen, Soren M; Bernstein, Jonine L; Evans, Jaden D; Gerber, Naamit K; Kerns, Sarah L; Keen, Judy; Litton, Jennifer K; Reiner, Anne S; Riaz, Nadeem; Rosenstein, Barry S; Sawakuchi, Gabriel O; Shaitelman, Simona F; Powell, Simon N; Woodward, Wendy A
PURPOSE AND METHODS/OBJECTIVE:The advent of affordable and rapid next-generation DNA sequencing technology, along with the US Supreme Court ruling invalidating gene patents, has led to a deluge of germline and tumor genetic variant tests that are being rapidly incorporated into clinical cancer decision making. A major concern for clinicians is whether the presence of germline mutations may increase the risk of radiation toxicity or secondary malignancies. Since minimal clinical data exist to inform decisions at this time, the American Society for Radiation Oncology (ASTRO) convened a group of radiation science experts and clinicians to summarize potential issues, review relevant data, and provide guidance for adult patients and their care teams regarding the impact, if any, that genetic testing should have on radiation therapy recommendations. RESULTS AND CONCLUSIONS/CONCLUSIONS:During the ASTRO Workshop, several main points emerged, which are discussed in this manuscript: 1) Variants of uncertain significance should be considered non-deleterious until functional genomic data emerges to demonstrate otherwise; 2) Possession of germline alterations in a single copy of a gene critical for radiation damage responses does not necessarily equate to increased risk of radiation-induced toxicity; 3) Deleterious ATM mutations may modestly increase second cancer risk after radiotherapy, thus follow-up for these patients after indicated radiotherapy should include second cancer screening; 4) Conveying to patients the difference between relative and absolute risk is critical to decision making; and 5) More work is needed to assess the impact of tumor somatic alterations on the probability of response to radiotherapy and the potential for individualization of radiation doses. Data on radiosensitivity related to specific genetic mutations is also briefly discussed.
PMID: 31381960
ISSN: 1879-355x
CID: 4034232

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Jiang, Xia; Finucane, Hilary K; Schumacher, Fredrick R; Schmit, Stephanie L; Tyrer, Jonathan P; Han, Younghun; Michailidou, Kyriaki; Lesseur, Corina; Kuchenbaecker, Karoline B; Dennis, Joe; Conti, David V; Casey, Graham; Gaudet, Mia M; Huyghe, Jeroen R; Albanes, Demetrius; Aldrich, Melinda C; Andrew, Angeline S; Andrulis, Irene L; Anton-Culver, Hoda; Antoniou, Antonis C; Antonenkova, Natalia N; Arnold, Susanne M; Aronson, Kristan J; Arun, Banu K; Bandera, Elisa V; Barkardottir, Rosa B; Barnes, Daniel R; Batra, Jyotsna; Beckmann, Matthias W; Benitez, Javier; Benlloch, Sara; Berchuck, Andrew; Berndt, Sonja I; Bickeböller, Heike; Bien, Stephanie A; Blomqvist, Carl; Boccia, Stefania; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Brauch, Hiltrud; Brenner, Hermann; Brenton, James D; Brook, Mark N; Brunet, Joan; Brunnström, Hans; Buchanan, Daniel D; Burwinkel, Barbara; Butzow, Ralf; Cadoni, Gabriella; Caldés, Trinidad; Caligo, Maria A; Campbell, Ian; Campbell, Peter T; Cancel-Tassin, Géraldine; Cannon-Albright, Lisa; Campa, Daniele; Caporaso, Neil; Carvalho, André L; Chan, Andrew T; Chang-Claude, Jenny; Chanock, Stephen J; Chen, Chu; Christiani, David C; Claes, Kathleen B M; Claessens, Frank; Clements, Judith; Collée, J Margriet; Correa, Marcia Cruz; Couch, Fergus J; Cox, Angela; Cunningham, Julie M; Cybulski, Cezary; Czene, Kamila; Daly, Mary B; deFazio, Anna; Devilee, Peter; Diez, Orland; Gago-Dominguez, Manuela; Donovan, Jenny L; Dörk, Thilo; Duell, Eric J; Dunning, Alison M; Dwek, Miriam; Eccles, Diana M; Edlund, Christopher K; Edwards, Digna R Velez; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Ferris, Robert L; Liloglou, Triantafillos; Figueiredo, Jane C; Fletcher, Olivia; Fortner, Renée T; Fostira, Florentia; Franceschi, Silvia; Friedman, Eitan; Gallinger, Steven J; Ganz, Patricia A; Garber, Judy; García-Sáenz, José A; Gayther, Simon A; Giles, Graham G; Godwin, Andrew K; Goldberg, Mark S; Goldgar, David E; Goode, Ellen L; Goodman, Marc T; Goodman, Gary; Grankvist, Kjell; Greene, Mark H; Gronberg, Henrik; Gronwald, Jacek; Guénel, Pascal; HÃ¥kansson, Niclas; Hall, Per; Hamann, Ute; Hamdy, Freddie C; Hamilton, Robert J; Hampe, Jochen; Haugen, Aage; Heitz, Florian; Herrero, Rolando; Hillemanns, Peter; Hoffmeister, Michael; Høgdall, Estrid; Hong, Yun-Chul; Hopper, John L; Houlston, Richard; Hulick, Peter J; Hunter, David J; Huntsman, David G; Idos, Gregory; Imyanitov, Evgeny N; Ingles, Sue Ann; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Jenkins, Mark A; Johansson, Mattias; Johansson, Mikael; John, Esther M; Joshi, Amit D; Kaneva, Radka; Karlan, Beth Y; Kelemen, Linda E; Kühl, Tabea; Khaw, Kay-Tee; Khusnutdinova, Elza; Kibel, Adam S; Kiemeney, Lambertus A; Kim, Jeri; Kjaer, Susanne K; Knight, Julia A; Kogevinas, Manolis; Kote-Jarai, Zsofia; Koutros, Stella; Kristensen, Vessela N; Kupryjanczyk, Jolanta; Lacko, Martin; Lam, Stephan; Lambrechts, Diether; Landi, Maria Teresa; Lazarus, Philip; Le, Nhu D; Lee, Eunjung; Lejbkowicz, Flavio; Lenz, Heinz-Josef; Leslie, Goska; Lessel, Davor; Lester, Jenny; Levine, Douglas A; Li, Li; Li, Christopher I; Lindblom, Annika; Lindor, Noralane M; Liu, Geoffrey; Loupakis, Fotios; LubiÅ„ski, Jan; Maehle, Lovise; Maier, Christiane; Mannermaa, Arto; Marchand, Loic Le; Margolin, Sara; May, Taymaa; McGuffog, Lesley; Meindl, Alfons; Middha, Pooja; Miller, Austin; Milne, Roger L; MacInnis, Robert J; Modugno, Francesmary; Montagna, Marco; Moreno, Victor; Moysich, Kirsten B; Mucci, Lorelei; Muir, Kenneth; Mulligan, Anna Marie; Nathanson, Katherine L; Neal, David E; Ness, Andrew R; Neuhausen, Susan L; Nevanlinna, Heli; Newcomb, Polly A; Newcomb, Lisa F; Nielsen, Finn Cilius; Nikitina-Zake, Liene; Nordestgaard, Børge G; Nussbaum, Robert L; Offit, Kenneth; Olah, Edith; Olama, Ali Amin Al; Olopade, Olufunmilayo I; Olshan, Andrew F; Olsson, HÃ¥kan; Osorio, Ana; Pandha, Hardev; Park, Jong Y; Pashayan, Nora; Parsons, Michael T; Pejovic, Tanja; Penney, Kathryn L; Peters, Wilbert H M; Phelan, Catherine M; Phipps, Amanda I; Plaseska-Karanfilska, Dijana; Pring, Miranda; Prokofyeva, Darya; Radice, Paolo; Stefansson, Kari; Ramus, Susan J; Raskin, Leon; Rennert, Gad; Rennert, Hedy S; van Rensburg, Elizabeth J; Riggan, Marjorie J; Risch, Harvey A; Risch, Angela; Roobol, Monique J; Rosenstein, Barry S; Rossing, Mary Anne; De Ruyck, Kim; Saloustros, Emmanouil; Sandler, Dale P; Sawyer, Elinor J; Schabath, Matthew B; Schleutker, Johanna; Schmidt, Marjanka K; Setiawan, V Wendy; Shen, Hongbing; Siegel, Erin M; Sieh, Weiva; Singer, Christian F; Slattery, Martha L; Sorensen, Karina Dalsgaard; Southey, Melissa C; Spurdle, Amanda B; Stanford, Janet L; Stevens, Victoria L; Stintzing, Sebastian; Stone, Jennifer; Sundfeldt, Karin; Sutphen, Rebecca; Swerdlow, Anthony J; Tajara, Eloiza H; Tangen, Catherine M; Tardon, Adonina; Taylor, Jack A; Teare, M Dawn; Teixeira, Manuel R; Terry, Mary Beth; Terry, Kathryn L; Thibodeau, Stephen N; Thomassen, Mads; Bjørge, Line; Tischkowitz, Marc; Toland, Amanda E; Torres, Diana; Townsend, Paul A; Travis, Ruth C; Tung, Nadine; Tworoger, Shelley S; Ulrich, Cornelia M; Usmani, Nawaid; Vachon, Celine M; Van Nieuwenhuysen, Els; Vega, Ana; Aguado-Barrera, Miguel Elías; Wang, Qin; Webb, Penelope M; Weinberg, Clarice R; Weinstein, Stephanie; Weissler, Mark C; Weitzel, Jeffrey N; West, Catharine M L; White, Emily; Whittemore, Alice S; Wichmann, H-Erich; Wiklund, Fredrik; Winqvist, Robert; Wolk, Alicja; Woll, Penella; Woods, Michael; Wu, Anna H; Wu, Xifeng; Yannoukakos, Drakoulis; Zheng, Wei; Zienolddiny, Shanbeh; Ziogas, Argyrios; Zorn, Kristin K; Lane, Jacqueline M; Saxena, Richa; Thomas, Duncan; Hung, Rayjean J; Diergaarde, Brenda; McKay, James; Peters, Ulrike; Hsu, Li; García-Closas, Montserrat; Eeles, Rosalind A; Chenevix-Trench, Georgia; Brennan, Paul J; Haiman, Christopher A; Simard, Jacques; Easton, Douglas F; Gruber, Stephen B; Pharoah, Paul D P; Price, Alkes L; Pasaniuc, Bogdan; Amos, Christopher I; Kraft, Peter; Lindström, Sara
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
PMID: 31548585
ISSN: 2041-1723
CID: 4105372

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci [Correction]

Schumacher, Fredrick R; Olama, Ali Amin Al; Berndt, Sonja I; Benlloch, Sara; Ahmed, Mahbubl; Saunders, Edward J; Dadaev, Tokhir; Leongamornlert, Daniel; Anokian, Ezequiel; Cieza-Borrella, Clara; Goh, Chee; Brook, Mark N; Sheng, Xin; Fachal, Laura; Dennis, Joe; Tyrer, Jonathan; Muir, Kenneth; Lophatananon, Artitaya; Stevens, Victoria L; Gapstur, Susan M; Carter, Brian D; Tangen, Catherine M; Goodman, Phyllis J; Thompson, Ian M; Batra, Jyotsna; Chambers, Suzanne; Moya, Leire; Clements, Judith; Horvath, Lisa; Tilley, Wayne; Risbridger, Gail P; Gronberg, Henrik; Aly, Markus; Nordström, Tobias; Pharoah, Paul; Pashayan, Nora; Schleutker, Johanna; Tammela, Teuvo L J; Sipeky, Csilla; Auvinen, Anssi; Albanes, Demetrius; Weinstein, Stephanie; Wolk, Alicja; HÃ¥kansson, Niclas; West, Catharine M L; Dunning, Alison M; Burnet, Neil; Mucci, Lorelei A; Giovannucci, Edward; Andriole, Gerald L; Cussenot, Olivier; Cancel-Tassin, Géraldine; Koutros, Stella; Beane Freeman, Laura E; Sorensen, Karina Dalsgaard; Orntoft, Torben Falck; Borre, Michael; Maehle, Lovise; Grindedal, Eli Marie; Neal, David E; Donovan, Jenny L; Hamdy, Freddie C; Martin, Richard M; Travis, Ruth C; Key, Tim J; Hamilton, Robert J; Fleshner, Neil E; Finelli, Antonio; Ingles, Sue Ann; Stern, Mariana C; Rosenstein, Barry S; Kerns, Sarah L; Ostrer, Harry; Lu, Yong-Jie; Zhang, Hong-Wei; Feng, Ninghan; Mao, Xueying; Guo, Xin; Wang, Guomin; Sun, Zan; Giles, Graham G; Southey, Melissa C; MacInnis, Robert J; FitzGerald, Liesel M; Kibel, Adam S; Drake, Bettina F; Vega, Ana; Gómez-Caamaño, Antonio; Szulkin, Robert; Eklund, Martin; Kogevinas, Manolis; Llorca, Javier; Castaño-Vinyals, Gemma; Penney, Kathryn L; Stampfer, Meir; Park, Jong Y; Sellers, Thomas A; Lin, Hui-Yi; Stanford, Janet L; Cybulski, Cezary; Wokolorczyk, Dominika; Lubinski, Jan; Ostrander, Elaine A; Geybels, Milan S; Nordestgaard, Børge G; Nielsen, Sune F; Weischer, Maren; Bisbjerg, Rasmus; Røder, Martin Andreas; Iversen, Peter; Brenner, Hermann; Cuk, Katarina; Holleczek, Bernd; Maier, Christiane; Luedeke, Manuel; Schnoeller, Thomas; Kim, Jeri; Logothetis, Christopher J; John, Esther M; Teixeira, Manuel R; Paulo, Paula; Cardoso, Marta; Neuhausen, Susan L; Steele, Linda; Ding, Yuan Chun; De Ruyck, Kim; De Meerleer, Gert; Ost, Piet; Razack, Azad; Lim, Jasmine; Teo, Soo-Hwang; Lin, Daniel W; Newcomb, Lisa F; Lessel, Davor; Gamulin, Marija; Kulis, Tomislav; Kaneva, Radka; Usmani, Nawaid; Singhal, Sandeep; Slavov, Chavdar; Mitev, Vanio; Parliament, Matthew; Claessens, Frank; Joniau, Steven; Van den Broeck, Thomas; Larkin, Samantha; Townsend, Paul A; Aukim-Hastie, Claire; Gago-Dominguez, Manuela; Castelao, Jose Esteban; Martinez, Maria Elena; Roobol, Monique J; Jenster, Guido; van Schaik, Ron H N; Menegaux, Florence; Truong, Thérèse; Koudou, Yves Akoli; Xu, Jianfeng; Khaw, Kay-Tee; Cannon-Albright, Lisa; Pandha, Hardev; Michael, Agnieszka; Thibodeau, Stephen N; McDonnell, Shannon K; Schaid, Daniel J; Lindstrom, Sara; Turman, Constance; Ma, Jing; Hunter, David J; Riboli, Elio; Siddiq, Afshan; Canzian, Federico; Kolonel, Laurence N; Le Marchand, Loic; Hoover, Robert N; Machiela, Mitchell J; Cui, Zuxi; Kraft, Peter; Amos, Christopher I; Conti, David V; Easton, Douglas F; Wiklund, Fredrik; Chanock, Stephen J; Henderson, Brian E; Kote-Jarai, Zsofia; Haiman, Christopher A; Eeles, Rosalind A
In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.
PMID: 30622367
ISSN: 1546-1718
CID: 3681572