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Nature neuroscience. 2021:24(8):1176-1186.DOI: 10.1038/s41593-021-00867-9

Baseline brain function in the preadolescents of the ABCD Study

Chaarani, B; Hahn, S; Allgaier, N; Adise, S; Owens, M M; Juliano, A C; Yuan, D K; Loso, H; Ivanciu, A; Albaugh, M D; Dumas, J; Mackey, S; Laurent, J; Ivanova, M; Hagler, D J; Cornejo, M D; Hatton, S; Agrawal, A; Aguinaldo, L; Ahonen, L; Aklin, W; Anokhin, A P; Arroyo, J; Avenevoli, S; Babcock, D; Bagot, K; Baker, F C; Banich, M T; Barch, D M; Bartsch, H; Baskin-Sommers, A; Bjork, J M; Blachman-Demner, D; Bloch, M; Bogdan, R; Bookheimer, S Y; Breslin, F; Brown, S; Calabro, F J; Calhoun, V; Casey, B J; Chang, L; Clark, D B; Cloak, C; Constable, R T; Constable, K; Corley, R; Cottler, L B; Coxe, S; Dagher, R K; Dale, A M; Dapretto, M; Delcarmen-Wiggins, R; Dick, A S; Do, E K; Dosenbach, N U F; Dowling, G J; Edwards, S; Ernst, T M; Fair, D A; Fan, C C; Feczko, E; Feldstein-Ewing, S W; Florsheim, P; Foxe, J J; Freedman, E G; Friedman, N P; Friedman-Hill, S; Fuemmeler, B F; Galvan, A; Gee, D G; Giedd, J; Glantz, M; Glaser, P; Godino, J; Gonzalez, M; Gonzalez, R; Grant, S; Gray, K M; Haist, F; Harms, M P; Hawes, S; Heath, A C; Heeringa, S; Heitzeg, M M; Hermosillo, R; Herting, M M; Hettema, J M; Hewitt, J K; Heyser, C; Hoffman, E; Howlett, K; Huber, R S; Huestis, M A; Hyde, L W; Iacono, W G; Infante, M A; Irfanoglu, O; Isaiah, A; Iyengar, S; Jacobus, J; James, R; Jean-Francois, B; Jernigan, T; Karcher, N R; Kaufman, A; Kelley, B; Kit, B; Ksinan, A; Kuperman, J; Laird, A R; Larson, C; LeBlanc, K; Lessov-Schlagger, C; Lever, N; Lewis, D A; Lisdahl, K; Little, A R; Lopez, M; Luciana, M; Luna, B; Madden, P A; Maes, H H; Makowski, C; Marshall, A T; Mason, M J; Matochik, J; McCandliss, B D; McGlade, E; Montoya, I; Morgan, G; Morris, A; Mulford, C; Murray, P; Nagel, B J; Neale, M C; Neigh, G; Nencka, A; Noronha, A; Nixon, S J; Palmer, C E; Pariyadath, V; Paulus, M P; Pelham, W E; Pfefferbaum, D; Pierpaoli, C; Prescot, A; Prouty, D; Puttler, L I; Rajapaske, N; Rapuano, K M; Reeves, G; Renshaw, P F; Riedel, M C; Rojas, P; de la Rosa, M; Rosenberg, M D; Ross, M J; Sanchez, M; Schirda, C; Schloesser, D; Schulenberg, J; Sher, K J; Sheth, C; Shilling, P D; Simmons, W K; Sowell, E R; Speer, N; Spittel, M; Squeglia, L M; Sripada, C; Steinberg, J; Striley, C; Sutherland, M T; Tanabe, J; Tapert, S F; Thompson, W; Tomko, R L; Uban, K A; Vrieze, S; Wade, N E; Watts, R; Weiss, S; Wiens, B A; Williams, O D; Wilbur, A; Wing, D; Wolff-Hughes, D; Yang, R; Yurgelun-Todd, D A; Zucker, R A; Potter, A; Garavan, H P
The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.
PMID: 34099922
ISSN: 1546-1726
CID: 4950912
International psychogeriatrics. 2006:18(4):631-41.DOI: 10.1017/S1041610206003437

Evaluation of a psychiatric day hospital program for elderly patients with mood disorders

Mackenzie, Corey S; Rosenberg, Marsha; Major, Melissa
BACKGROUND: Very little is known about the utility of psychiatric day hospitals for elderly adults with mood disorders. The objectives of this study were to evaluate a long-standing day-hospital program and to explore whether demographic and non-demographic patient characteristics were associated with treatment outcomes. METHOD: We used t-tests to compare retrospective admission and discharge data for 708 patients over a 16-year period, and multiple regression to examine predictors of improvement. RESULTS: Depressed patients showed statistically and clinically significant improvements on the Geriatric Depression Scale and the Hamilton Depression Rating Scale. The number and severity of depressive symptoms at admission were strongly related to treatment outcomes. After controlling for initial levels of depression, demographic characteristics did not predict improvement, and axis I and II diagnoses modestly and inconsistently predicted improvement. CONCLUSIONS: A biopsychosocially-focused day-hospital treatment program was associated with improvements in depression in a large sample of elderly adults with mood disorders. Except for depression severity at admission, patient characteristics had very little impact on treatment outcomes, suggesting that day hospital programs are beneficial for a wide range of depressed elderly adults.
PMID: 16684397
ISSN: 1041-6102
CID: 160190