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Erratum to: The gut microbiota in conventional and serrated precursors of colorectal cancer [Correction]

Peters, Brandilyn A; Dominianni, Christine; Shapiro, Jean A; Church, Timothy R; Wu, Jing; Miller, George; Yuen, Elizabeth; Freiman, Hal; Lustbader, Ian; Salik, James; Friedlander, Charles; Hayes, Richard B; Ahn, Jiyoung
PMCID:5338091
PMID: 28264712
ISSN: 2049-2618
CID: 2476172

The gut microbiota in conventional and serrated precursors of colorectal cancer

Peters, Brandilyn A; Dominianni, Christine; Shapiro, Jean A; Church, Timothy R; Wu, Jing; Miller, George; Yuen, Elizabeth; Freiman, Hal; Lustbader, Ian; Salik, James; Friedlander, Charles; Hayes, Richard B; Ahn, Jiyoung
BACKGROUND: Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. We and others have previously shown a relationship between the human gut microbiota and colorectal cancer; however, its relationship to the different early precursors of colorectal cancer is understudied. We tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types. RESULTS: Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples. Participants were categorized as CA cases (n = 144), serrated polyp cases (n = 73), or polyp-free controls (n = 323). CA cases were further classified as proximal (n = 87) or distal (n = 55) and as non-advanced (n = 121) or advanced (n = 22). Serrated polyp cases were further classified as hyperplastic polyp (HP; n = 40) or sessile serrated adenoma (SSA; n = 33). We compared gut microbiota diversity, overall composition, and normalized taxon abundance among these groups. CA cases had lower species richness in stool than controls (p = 0.03); in particular, this association was strongest for advanced CA cases (p = 0.004). In relation to overall microbiota composition, only distal or advanced CA cases differed significantly from controls (p = 0.02 and p = 0.002). In taxon-based analysis, stool of CA cases was depleted in a network of Clostridia operational taxonomic units from families Ruminococcaceae, Clostridiaceae, and Lachnospiraceae, and enriched in the classes Bacilli and Gammaproteobacteria, order Enterobacteriales, and genera Actinomyces and Streptococcus (all q < 0.10). SSA and HP cases did not differ in diversity or composition from controls, though sample size for these groups was small. Few taxa were differentially abundant between HP cases or SSA cases and controls; among them, class Erysipelotrichi was depleted in SSA cases. CONCLUSIONS: Our results indicate that gut microbes may play a role in the early stages of colorectal carcinogenesis through the development of CAs. Findings may have implications for developing colorectal cancer prevention therapies targeting early microbial drivers of colorectal carcinogenesis.
PMCID:5203720
PMID: 28038683
ISSN: 2049-2618
CID: 2388442

Retinoid hepatitis [see comments] [Comment]

Sanchez MR; Ross B; Rotterdam H; Salik J; Brodie R; Freedberg IM
A 65-year-old woman treated with etretinate for pityriasis rubra pilaris developed chronic active hepatitis. The elevated transaminases were noted 2 months after initiation of therapy and peaked 2 months after discontinuation of etretinate. The spectrum of liver toxicity induced by etretinate is reviewed. We suggest that reported cases of retinoid-induced liver disease can be divided into four distinct categories: nonspecific reactive hepatitis, acute hepatitis, chronic active hepatitis, and severe fibrosis or cirrhosis
PMID: 8491880
ISSN: 0190-9622
CID: 13168

SEVERE HYPONATREMIA AFTER COLONOSCOPY PREPARATION IN A PATIENT WITH THE ACQUIRED IMMUNE-DEFICIENCY SYNDROME

SALIK, JM; KURTIN, P
ISI:A1985ADE4700004
ISSN: 0002-9270
CID: 41246

STRESS-TESTING WITH THALLIUM 201 IMAGING TO DETECT LATENT CORONARY-DISEASE IN HEMODIALYSIS-PATIENTS [Meeting Abstract]

Katz, LA; Fisher, VJ; Salik, JM; Agatson, A; Rubler, S
ISI:A1979HY94000494
ISSN: 0085-2538
CID: 29994

STRESS-TESTING WITH TL-201 IMAGING TO DETECT LATENT CORONARY- DISEASE IN HEMODIALYSIS-PATIENTS [Meeting Abstract]

Katz, LA; Fisher, VJ; Salik, JM; Agatson, A; Rubler, S
ISI:A1979GR63101646
ISSN: 0009-9279
CID: 30015