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Validation of an Index for Functionally Important Respiratory Symptoms among Adults in the Nationally Representative Population Assessment of Tobacco and Health Study, 2014-2016

Halenar, Michael J; Sargent, James D; Edwards, Kathryn C; Woloshin, Steven; Schwartz, Lisa; Emond, Jennifer; Tanski, Susanne; Pierce, John P; Taylor, Kristie A; Lauten, Kristin; Goniewicz, Maciej L; Niaura, Raymond; Anic, Gabriella; Chen, Yanling; Callahan-Lyon, Priscilla; Gardner, Lisa D; Thekkudan, Theresa; Borek, Nicolette; Kimmel, Heather L; Cummings, K Michael; Hyland, Andrew; Brunette, Mary F
The purpose of this study is to validate the seven-item wheezing module from the International Study of Asthma and Allergies in Children (ISAAC) in the nationally representative Population Assessment of Tobacco and Health Study. Adult participants with complete Wave 2-3 data were selected, including those with asthma but excluding those with COPD and other respiratory diseases (n = 16,295). We created a nine-point respiratory symptom index from the ISAAC questions, assessed the reliability of the index, and examined associations with self-reported asthma diagnosis. Threshold values were assessed for association with functional outcomes. The weighted prevalence for one or more respiratory symptom was 18.0% (SE = 0.5) for adults without asthma, 70.1% (SE = 1.3) for those with lifetime asthma, 75.7% (SE = 3.7) for adults with past-year asthma not on medications, and 92.6% (SE = 1.6) for those on medications. Cronbach's alpha for the respiratory symptom index was 0.86. Index scores of ≥2 or ≥3 yielded functionally important respiratory symptom prevalence of 7-10%, adequate sensitivity and specificity for identifying asthma, and consistent independent associations with all functional outcomes and tobacco use variables. Respiratory symptom index scores of ≥2 or ≥3 are indicative of functionally important respiratory symptoms and could be used to assess the relationship between tobacco use and respiratory health.
PMCID:8467923
PMID: 34574610
ISSN: 1660-4601
CID: 5070202

One foot forward, two steps back [Meeting Abstract]

Schwartz, L C; Desai-Oghra, S; Moussa, M
Learning Objectives: Radiologist interpretations contribute to anchoring bias. Differentiating problems with similar presentations requires thorough exams and detailed patient histories. Correct management often requires a patient-centered approach. Case Information: A 48 year old woman developed a limp from pain in the ball of the right foot while training for her fifth half marathon. A radiologist diagnosed Freiberg's Disease Stage 2, a rare avascular necrosis of the metatarsal head, based on an x-ray ordered by her podiatrist. X-ray findings include flattening of the metatarsal head, which is a normal variant in 10% of people. The podiatrist prescribed a fracture boot. The patient consulted an orthopedist who changed management to a metatarsal pad for her insole after reviewing the x-ray without an alternative diagnosis. Doubting her diagnosis, the patient consulted a physiatrist who confirmed Freiberg's Disease. After 6 weeks of pain, her orthopedist ordered an MRI that ruled out Freiberg's and showed a partial plantar plate tear with significant localized bursitis. She was taught to tape her toe, but pain persisted with the metatarsal pad. A new podiatrist noticed that the metatarsal pad was creating gait problems and he altered her running shoe insole instead. After two weeks, she was running again.
Discussion(s): Metatarsalgia has many causes, yet three doctors anchored their diagnosis on an incorrect radiology report. Listening to the nuances of the patient's story and performing an extensive exam may have expedited the correct diagnosis. Many doctors use metatarsal pads, but this management may cause harm in some patients. (Figure Presented)
EMBASE:630960903
ISSN: 2194-802x
CID: 4326272

Subclavian steal syndrome due to dialysis fistula corrected with subclavian artery stenting

Agarwal, Shashank; Schwartz, Lisa; Kwon, Patrick; Selas, George; Farkas, Jeffrey; Arcot, Karthikeyan; Tiwari, Ambooj
PMCID:6276325
PMID: 30564504
ISSN: 2163-0402
CID: 3556582

Subclavian Steal Syndrome secondary to Dialysis AVF treated with Balloon Mounted Stent [Meeting Abstract]

Agarwal, Shashank; Kwon, Patrick; Selas, George; Farkas, Jeffrey; Arcot, Karthikeyan; Schwartz, Lisa; Tiwari, Ambooj
ISI:000453090804458
ISSN: 0028-3878
CID: 3561412