Try a new search

Format these results:

Searched for:

person:shuklh01

Total Results:

8


Bilirubin in cerebrospinal fluid: an indicator of blood-brain barrier disruption in asphyxiated rats

Shukla H; Atakent YS; Ferrara A; Pincus M; Greco A
To evaluate the relationship of serum cerebrospinal fluid (CSF) and brain total bilirubin levels in asphyxia, an experiment was designed with 5 to 6-week-old Sprague-Dawley rats. The rats were randomized into control and experimental groups. All rats received intravenously 30 mg/kg of bilirubin. Four hours later the experimental group was asphyxiated. Forty-eight hours after asphyxiation, the bilirubin concentrations in blood, CSF, and brain were measured in both study groups. Mean CSF and brain bilirubin levels were significantly higher in the experimental compared to the control group; however, mean serum bilirubin levels were not different. Moreover, in the experimental group a significant correlation existed between CSF and brain bilirubin concentrations. In conclusion, an asphyxiatic insult resulted in disruption of both the blood-brain and the blood-CSF barriers
PMID: 3193261
ISSN: 0743-8346
CID: 11250

Postnatal overestimation of gestational age in preterm infants

Shukla, H; Atakent, Y S; Ferrara, A; Topsis, J; Antoine, C
In a study involving 25 preterm infants, obstetric clinical age (standard gestational age) was determined by history, physical examination, and ultrasonographic evaluation. Postnatally, these infants were then evaluated using the Dubowitz Scoring System (DSS) for gestational age assessment. The DSS, as administered by us, significantly overestimated gestational age compared with the standard gestational age (mean +/- 1 SD: 34.2 +/- 2.9 vs 32.5 +/- 3.9 weeks, respectively) in preterm infants. To illustrate, the gestational ages of 13 newborns (52%) in the total study group were each overestimated by more than two weeks. This percentage increased to 75% among the 16 infants whose gestational ages were less than 34 weeks (by standard gestational age). When the standard gestational age was underestimated by the DSS, this difference never exceeded two weeks. These findings suggest that the present system of postnatal assessment of gestational age in preterm infants needs further investigation.
PMID: 3307384
ISSN: 0002-922x
CID: 323732

VALIDITY OF A RAPID ESTIMATION OF INSERTIONAL LENGTH OF NEONATAL OROTRACHEAL (OT) INTUBATION [Meeting Abstract]

Shukla, H; Sundaram, U; Ferrara, A; Atakent, Y; Lione, J; Rapaport, S
ISI:A1987G700501219
ISSN: 0031-3998
CID: 31398

Rapid estimation of insertional length of umbilical catheters in newborns

Shukla, H; Ferrara, A
To determine the neonatal body measurement that best predicts insertional umbilical catheter lengths, we studied two commonly used parameters--shoulder-to-umbilicus length and total body length--and two new parameters--suprasternal notch-pubic symphysis length and birth weight (BW)--on 43 umbilical artery (UA) and ten umbilical vein (UV) catheterizations. The new parameters showed better correlations than the currently used ones. The BW variable, with the highest coefficient of correlation among all four parameters, was applied prospectively in 25 UA and 16 UV catheter insertions. All catheter tips thus placed were found to be in acceptable positions. Although any one of the four parameters can be used clinically, we prefer the BW parameter for its reliability, reproducibility, and ability to be estimated in emergency settings. The modified regression (estimating) equations utilizing BW are as follows: UA catheter length = 3 X BW + 9; UV catheter length = 1/2 X UA line calculation + 1, in which lengths are measured in centimeters and BW is measured in kilograms.
PMID: 3728405
ISSN: 0002-922x
CID: 3692882

BILIRUBIN IN CEREBROSPINAL-FLUID - AN INDICATOR OF BLOOD-BRAIN-BARRIER (BBB) DISRUPTION [Meeting Abstract]

Shukla, H; Ferrara, A; Pincus, M; Greco, A
ISI:A1986A712000267
ISSN: 0031-3998
CID: 31067

OVERESTIMATION OF GESTATION AGE (GA) IN PRETERM INFANTS [Meeting Abstract]

Shukla, H; Ferrara, A; Atakent, Y; Topsis, J; Antoine, C
ISI:A1986A712001247
ISSN: 0031-3998
CID: 31071

SEX SPECIFIC DIFFERENCES IN RESPIRATORY TOLERANCE IN RAT SUCKLINGS (RS) UNDERGOING ASPHYCTIC EPISODES [Meeting Abstract]

Atakent, Y; Ferrara, A; Shukla, H; Ankola, P; Topsis, J; Klupsteen, M
ISI:A1985AEU1800233
ISSN: 0031-3998
CID: 30760

The effects of steroids on respiratory tolerance and somatic growth in gender-specific asphyxiated newborn rats

Atakent, Y S; Ferrara, A; Shukla, H
Gender-specific newborn rats were randomized into two treatment groups: experimental (received steroid) and control (administered normal saline). Steroid treatment was initiated on 2nd day of life. Hydrocortisone sodium succinate at 10 mg/kg was administered intraperitoneally every 12 hours for four doses. On 3rd day of life, after the last dosage, all rats were asphyxiated once in a standardized manner. Steroids had no effect in improving respiratory tolerance. The experimental group in both genders, but more predominantly in females, gained less body weight compared to control littermates. However, no differences in somatic growth was detected between genders. This finding in newborn rats is in contrast to older rats where males are reported to be less resistant to the growth retarding effects of steroids.
PMID: 3835109
ISSN: 0017-4793
CID: 323742