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Transformation of porokeratosis ptychotropica into invasive squamous cell carcinoma [Case Report]

Mazori, Daniel R; Shvartsbeyn, Marianna; Meehan, Shane A; Tarsis, Sara L
PMID: 28197991
ISSN: 1365-4632
CID: 2449172

Diaper dermatitis

Chapter by: Tarsis SL; Orlow SJ
in: Current dermatologic diagnosis & treatment by Freedberg IM; Sanchez MR [Eds]
Philadelphia : Lippincott Williams & Wilkins, 2001
pp. 48-49
ISBN: 0781735319
CID: 3694

Kawasaki disease

Chapter by: Tarsis SL; Chang MW
in: Current dermatologic diagnosis & treatment by Freedberg IM; Sanchez MR [Eds]
Philadelphia : Lippincott Williams & Wilkins, 2001
pp. 92-93
ISBN: 0781735319
CID: 3712

Neonatal dermatology: transient lesions

Chapter by: Tarsis SL; Weinberg S
in: Current dermatologic diagnosis & treatment by Freedberg IM; Sanchez MR [Eds]
Philadelphia : Lippincott Williams & Wilkins, 2001
pp. 122-123
ISBN: 0781735319
CID: 3725

Pediatric exanthems

Chapter by: Tarsis Sl; Chang MW
in: Current dermatologic diagnosis & treatment by Freedberg IM; Sanchez MR [Eds]
Philadelphia : Lippincott Williams & Wilkins, 2001
pp. 146-147
ISBN: 0781735319
CID: 3736

Human T-lymphocyte transformation with human T-cell lymphotropic virus type 2

Tarsis SL; Yu MT; Parks ES; Persaud D; Munoz JL; Parks WP
Human T-cell lymphotrophic virus type 2 (HTLV-2), a common infection of intravenous drug users and subpopulations of Native Americans, is uncommon in the general population. In contrast with the closely related HTLV-1, which is associated with both leukemia and neurologic disorders, HTLV-2 lacks a strong etiologic association with disease. HTLV-2 does shares many properties with HTLV-1, including in vitro lymphocyte transformation capability. To better assess the ability of HTLV-2 to transform lymphocytes, a limiting dilution assay was used to generate clonal, transformed lymphocyte lines. As with HTLV-1, the transformation efficiency of HTLV-2 producer cells was proportionately related to the number of lethally irradiated input cells and was comparable to HTLV-1-mediated transformation efficiency. HTLV-2-infected cells were reproducibly isolated and had markedly increased growth potential compared to uninfected cells; HTLV-2 transformants required the continued presence of exogenous interleukin 2 for growth for several months and were maintained for over 2 years in culture. All HTLV-2-transformed populations were CD2 and/or CD3 positive and B1 negative and were either CD4+ or CD8+ populations or a mixture of CD4+ and CD8+ lymphocytes. Clonality of the HTLV-2 transformants was confirmed by Southern blot analysis of T-cell receptor beta chain rearrangement. Southern blot analysis revealed a range of integrated full-length genomes from one to multiple. In situ hybridization analysis of HTLV-2 integration revealed no obvious chromosomal integration pattern
PMCID:109446
PMID: 9420297
ISSN: 0022-538x
CID: 57349

Time course and cytokine dependence of human T-cell lymphotropic virus type 1 T-lymphocyte transformation as revealed by a microtiter infectivity assay

Persaud D; Munoz JL; Tarsis SL; Parks ES; Parks WP
Human T-cell lymphotropic virus type 1 (HTLV-1) enhances the growth of T lymphocytes, allowing the generation of T-lymphocyte cell lines. This report describes a limiting-dilution assay system which uses low input numbers of HTLV-1-producing cells for generation of T-lymphocyte cultures. The HTLV-1 transformants generated with this assay system produced high levels of HTLV-1 p24 antigen and required exogenous cytokines for maintenance. Clonal populations of CD4- or CD8-positive HTLV-1 transformants were generated with transformation efficiency rates as high as 78%. An exogenous cytokine is necessary for HTLV-1 T-lymphocyte transformation, and cytokine dependence is the most likely outcome of infection and transformation. HTLV-1 T-lymphocyte transformation can occur in the presence of cytokines other than interleukin-2 (IL-2), such as IL-4 or IL-7. IL-4- or IL-7-dependent HTLV-1 transformants underwent T-lymphocyte mitogenesis in response to their homologous cytokines but proliferated best in the presence of IL-2. Since the receptors for IL-2, IL-4, and IL-7 share the IL-2 gamma chain, this component may be the common element in the signaling pathway for HTLV-1-associated transformation
PMCID:189528
PMID: 7666530
ISSN: 0022-538x
CID: 56785

HTLV-1 LIMITING DILUTION T-LYMPHOCYTE TRANSFORMATION [Meeting Abstract]

PARKS, W; PERSAUD, D; TARSIS, S; MUNOZ, J; PARKS, E
ISI:A1994PF06600344
ISSN: 0889-2229
CID: 52371

CHARACTERIZATIONS OF HUMAN T-LYMPHOCYTES TRANSFORMED IN-VITRO BY HUMAN T-CELL LEUKEMIA-VIRUS [Meeting Abstract]

TARSIS, S; PARKS, W; PARKS, E; PERSAUD, D; MUNOZ, J
ISI:A1994NK47000099
ISSN: 0889-2229
CID: 52452

Analysis of the macular pigment by HPLC: retinal distribution and age study

Bone, R A; Landrum, J T; Fernandez, L; Tarsis, S L
High performance liquid chromatography (HPCL) has been employed to study the distribution throughout the human retina of zeaxanthin and lutein, the two major components of the macular pigment. Differences between individuals have also been studied with a view to uncovering possible age-related effects. Both pigments were detected in prenatal eyes (approximately 20 weeks gestation) but did not form a visible yellow spot. Generally they were not easily discernible until about 6 months after birth. For 87 donors between the ages of 3 and 95, no dependence on age was observed in the quantity of either pigment. For approximately 90% of these, zeaxanthin was dominant. For the remaining 10%, as well as for the seven youngest donors, all below the age of 2, and in prenatal eyes, lutein was the major pigment. In individual retinas, the lutein:zeaxanthin ratio increased from an average of approximately 1:2.4 in the central 0-0.25 mm to over 2:1 in the periphery (8.7-12.2 mm). The variation in this ratio with eccentricity was linearly correlated with the corresponding rod:cone ratio. A selective mechanism of uptake, which results in cones and rods preferentially acquiring zeaxanthin and lutein, respectively, could explain this correlation.
PMID: 3372161
ISSN: 0146-0404
CID: 157513