Faculty Bibliography

The effects of hypertonic glucose infusion on the anginal threshold determined by atrial pacing was studied in 14 patients with significant coronary artery disease. After glucose, angina occurred at a significantly lower heart rate and double product (systolic arterial pressure x heart rate), suggesting a decreased tolerance to ischemic stress. No stoichiometric relationship was noted between glucose uptake and lactate production, and there was no evidence that hypertonic glucose infusion resulted in enhanced anaerobic glycolysis in the ischemic myocardium. Acute elevation of plasma glucose levels may not be beneficial to patients with coronary artery disease.

The occurrence of severe aortic regurgitation in two patients with typical findings of osteogenesis imperfecta is described. Both patients manifested severe haemodynamic abnormalities and underwent successful aortic valve replacement. The operative and pathological findings are discussed