Faculty Bibliography

Background/UNASSIGNED:The Haitian orphanage sector receives more than 70 million United States Dollars (USD) in foreign aid annually and continues grow; there are over 500 orphanages in Port-Au-Prince alone. An estimated 80% of the 30,000 children living in Haitian orphanages have at least one living parent. Objectives/UNASSIGNED:This research seeks to identify factors contributing to maternal-child separation in Port-Au-Prince to understand motivations and attitudes surrounding maternal-child separation. We hypothesized that poverty, health status, and current state of the family unit are influential in the mother's decision to separate from her child. Methods/UNASSIGNED:From June to August 2017, a chain referral sampling study was conducted in Port-Au-Prince and the surrounding metropolitan area. Seventy interviews were conducted with (1) Mothers - separated (n = 8) and non-separated (n = 48) - and (2) Community leaders exposed to maternal-child separation (n = 18). The semi-structured interview consisted of questions about (1) exposure to maternal-child separation, (2) circumstances surrounding maternal-child separation, and (3) factors contributing to maternal-child separation. Additionally, all mothers completed a survey including demographic information and multiple validated surveys: Maternal Postpartum Quality of Life, Patient Health Questionnaire (PHQ-9), and PTSD Checklist (PCL) to address quality of life, depression, and PTSD, respectively. Findings/UNASSIGNED:This study found separation to be associated with poor economic means compounded with other factors, most notably access to education, ability to care for disabled children, insufficient support, and poor maternal mental health. Additional themes identified include negative stigma towards maternal-child separation and sparse education surrounding family planning. Quantitative findings revealed separated mothers experienced significantly higher rates of PTSD compared to non-separated, small but statistically worse quality of life, and no difference in rates of major depression. Conclusion/UNASSIGNED:This research finds economic means to be insufficient in predicting maternal-child separation, with access to education being the most salient contributing factor mentioned after economics. Findings from this study will inform development of programming focusing on education, family planning, and social support in Port-Au-Prince.

OBJECTIVE: Nonadherence to antidepressant treatment may contribute to poor outcome and to suicidal adverse events in adolescent depression. We examine the relationship between adherence and both clinical response and suicidal events in participants in the Treatment of Resistant Depression in Adolescents (TORDIA) study. METHOD: The relationship between adherence to medication and clinical outcome was assessed in 190 treatment-resistant depressed adolescents who were randomized to one of four cells: switch to another selective serotonin reuptake inhibitor (SSRI), switch to venlafaxine, or either of these two medication switches plus cognitive behavioral therapy. Plasma levels of antidepressant drug and metabolites were determined after 6 and 12 weeks of treatment. A twofold or greater variation in the dose-adjusted concentration of drug plus metabolites (level/dose ratio [LDR]) was defined as nonadherence. Nonadherence was also determined by clinician pill counts (CPC) of the proportion of prescribed pills that were unused and was defined as having greater than 30% of the prescribed pills remaining. RESULTS: LDR and CPC showed low concordance. LDR was unrelated to clinical response. CPC adherence was related to a higher response rate overall (adherent, 63.0% versus nonadherent, 47.2%, p = .03). Approximately half (50.8%) of the sample surveyed showed evidence of nonadherence by CPC. Neither measure of adherence was related to the occurrence of suicidal events or to the pace of decline in suicidal ideation. CONCLUSIONS: Clinician pill counts may be a relevant measure of adherence that is related to outcome under formal clinical trial conditions in depressed adolescents. Nonadherence appears to be a common and significant source of treatment nonresponse. Clinical Trial Registration Information-Treatment of SSRI-Resistant Depression in Adolescents (TORDIA); http://www.clinicaltrials.gov; NCT00018902.