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Heparin Resistance due to an Acquired Antithrombin Deficiency in a Patient With Sickle Cell Disease During a Pregnancy Complicated by Bilateral Pulmonary Emboli: A Case Report

Wells, Ashley V; Zarkhin, Eli; Weiner, Menachem M; Katz, Daniel
We report a 31-year-old woman with sickle beta thalassemia zero who presented at 21 weeks gestational age with multiple bilateral pulmonary emboli and no hemodynamic instability. Acquired antithrombin deficiency was suspected due to a refractory response to therapeutic anticoagulation with enoxaparin, unfractionated heparin, and fondaparinux, and a reduced antithrombin antigen level. At 26 4/7 weeks, she developed signs concerning for increased pulmonary clot burden. To avoid the use of alternative anticoagulants that may cross the placenta and impact the fetus, a planned cesarean delivery was performed without complication at 27 weeks gestation. Both mother and child experienced successful long-term outcomes.
PMID: 31048599
ISSN: 2575-3126
CID: 3918572

Carotenoid 9 ', 10 '-monooxygenase: Tumor Suppressor Activity in Prostate Cancer [Meeting Abstract]

Gong, Xiaoming; Zaripheh, Susan; Xiao, Fan; Zarkhin, Eli; Buch, Vivek P.; Magi-Galluzzi, Cristina; Rubin, Lewis P.
ISI:000208467807339
ISSN: 0892-6638
CID: 3181102

Receptor-dependent lycopene uptake in vivo: studies in scavenger receptor null mice [Meeting Abstract]

Zarkhin, Eli; Zaripheh, Susan; Gong, Xiaoming; Xiao, Fan; Febbraio, Maria; Rubin, Lewis P.
ISI:000208467808708
ISSN: 0892-6638
CID: 3181112

A novel role for beta-carotene 9,10-monooxygenase 2 in prostate cancer cells [Meeting Abstract]

Gong, Xiaoming; Zaripheh, Susan; Zarkhin, Eli; Gong, Wenrong; Rubin, Lewis P.
ISI:000245708500232
ISSN: 0892-6638
CID: 3181132

Identification of a transdominant negative splice variant of b-carotene 9 ',10 '-monoxygenase [Meeting Abstract]

Gong, Wenrong; Gong, Xiaoming; Zaripheh, Susan; Zarkhin, Eli; Rubin, Lewis
ISI:000245708503015
ISSN: 0892-6638
CID: 3181122