Try a new search

Format these results:

Searched for:

person:zhangx25

in-biosketch:true

Total Results:

38


Histotripsy of Subcutaneous Fat in a Live Porcine Model

Swietlik, John F; Knott, Emily A; Longo, Katherine C; Zlevor, Annie M; Zhang, Xiaofei; Laeseke, Paul F; Reeder, Scott B; Xu, Zhen; Lee, Fred T; Ziemlewicz, Timothy J
PURPOSE/OBJECTIVE:This study was designed to evaluate the feasibility and safety of histotripsy subcutaneous (SQ) fat treatment in an in-vivo porcine model, and evaluate evolution of the treated volume on MRI and pathology. METHODS/MATERIALS/METHODS:10 histotripsy SQ fat treatments were completed in 5 swine, divided into four groups based on pre-determined survival: day 0 (n = 4), day 7 (n = 2), day 28 (n = 2), and day 56 (n = 2). A 4.0 × 4.0x2.0 cm ovoid treatment was created in the fat pad of the posterior thorax. MRI of survived animals were obtained on day 7 (n = 6), day 28 (n = 4), and day 56 (n = 2), and reviewed for size and imaging characteristics. Technical success was defined as the creation of a treatment zone in the targeted SQ fat. Skin firmness and indentation were qualitatively scored. RESULTS:(± 1.2) by day 56 (92% overall decrease). Mean firmness and indentation scores showed no change from baseline at all time points, with no overlying skin injury. CONCLUSION/CONCLUSIONS:Histotripsy safely and effectively treated SQ fat of an in-vivo porcine model, with volume reduction over time.
PMID: 36097074
ISSN: 1432-086x
CID: 5346662

Constrictive and Hypertrophic Strictures in Ileal Crohn's Disease

Liu, Qingqing; Zhang, Xiaofei; Ko, Huaibin Mabel; Stocker, Daniel; Ellman, Jordan; Chen, Joyce; Hao, Yansheng; Bhardwaj, Swati; Liang, Yuanxin; Cho, Judy; Colombel, Jean Frederic; Taouli, Bachir; Harpaz, Noam
BACKGROUND & AIMS:Strictures in Crohn's disease (CD) are classically attributed to fibromuscular hypertrophy of the intestinal wall. We have identified and characterized CD-related ileal strictures that result instead from mural constriction (ie, reduced external circumference). METHODS:Twenty-four strictures and internal controls from 17 adults with obstructive CD were analyzed by cross-sectional morphometry. RESULTS:The stricture-to-control circumference ratios (CRs) ranged from 0.53 to 1.7. Six strictures with CR ≥1.0, designated hypertrophic, had concentrically thickened walls, mean 3-fold increases in cross-sectional area and stainable fibromucular tissue, and high transmural inflammation scores. In contrast, 18 strictures with CR <1.0, designated constrictive, had thin, pliant walls, cross-sectional areas and stainable fibromuscular tissue comparable with control values, and low transmural inflammation scores. Eight mildly constrictive strictures also showed mild fibromuscular mural expansion that fell short of statistical significance. Twelve of 18 constrictive strictures (67%) occurred multiply (2-4 strictures per specimen) in contrast with hypertrophic strictures, all of which occurred singly (P = .01). Constriction correlated quantitatively with circumferential serosal fat wrapping (P = .003) and was associated with myenteric lymphocytic plexitis (P = .02). Disease duration was shortest among subjects with constrictive strictures and correlated with increasing circumference (CR ≤0.8, 6.3 ± 6.2 years; CR >0.8, 8.7 ± 6.4 years; and CR ≥1.00, 13.7 ± 5.0 years, respectively; P = .03). CONCLUSIONS:Constrictive ileal strictures in CD differ pathologically and clinically from hypertrophic strictures, featuring little or no fibromuscular mural expansion, frequent multiplicity, and earlier onset. Mesenteric fat wrapping and myenteric plexitis may contribute to their pathogenesis. Pathologic manifestations of constriction and hypertrophy can coexist, suggesting that stricture heterogeneity may be shaped in part by the dynamics of constrictive and hypertrophic processes.
PMID: 34400338
ISSN: 1542-7714
CID: 5346592

Severe Cholestatic Hepatitis Secondary to SARS-CoV-2 [Case Report]

Lindholm, Christopher R; Zhang, Xiaofei; Spengler, Erin K; Daniel, Kimberly E
Liver injury is a common manifestation of coronavirus disease 2019 (COVID-19), with most injuries manifesting as transient mild hepatocellular injury. Cholestatic injury occurs less commonly and is typically mild. Severe cholestatic injury is rare, with only 4 cases reported in the literature. We present a 70-year-old woman with no known liver disease who presented with severe COVID-19 and developed severe cholestatic hepatitis. A liver biopsy was performed demonstrating bile duct injury, uncommonly reported in patients with COVID-19. This complication needs greater awareness because it has been known to cause progressive liver disease requiring transplantation.
PMCID:8963841
PMID: 35359752
ISSN: 2326-3253
CID: 5346572

A comparative study of the genotype profiles of high-risk human papillomavirus infection in male and female HIV-positive patients and their correlation with anal cytology and biopsy

Zhang, Xiaofei; Lu, Dan; Szporn, Arnold H; Zakowski, Maureen F; Si, Qiusheng
INTRODUCTION:Although anal cancer is more common in women, most of the studies on the role of high-risk human papillomavirus (hrHPV) infection in anal squamous lesions have focused on high-risk male patients. Therefore, we compared the genotype profile and clinicopathologic correlation of hrHPV infection in human immunodeficiency virus-positive (HIV+) men and women. MATERIALS AND METHODS:We retrospectively analyzed 2254 HIV+ patients (1931 men and 323 women) who had undergone anal Papanicolaou tests at our institution; 1189 of them also had follow-up biopsy data available. HPV genotyping was performed using the Roche Cobas system and correlated with the cytologic and histologic diagnosis. RESULTS:Compared with the HIV+ men, the HIV+ women had a significantly lower rate of hrHPV infection (67.5% versus 78.5%; P < 0.0001) but a significantly higher rate of high-grade squamous intraepithelial lesions (HSILs) on anal Papanicolaou tests (4.6% versus 2.5%; P < 0.05). Other high-risk HPV (ohrHPV), as a group, is much more common than HPV16 or HPV18 in both genders. HIV+ women had significantly lower HPV16 and ohrHPV infection rates than did HIV+ men. However, the HPV18 infection rates were similar between HIV+ women and HIV+ men. For both genders, the rates of HSILs or high-grade anal intraepithelial neoplasia (AIN2-3) were significantly increased when coinfection of ohrHPV with either HPV16 or HPV18 was present. CONCLUSIONS:Although both HIV+ men and HIV+ women have an increased risk of hrHPV infection, HIV+ women have different hrHPV genotype profiles and higher rates of high-grade lesions. Coinfection with different genotypes of hrHPV can significantly increase the risk of HSILs or AIN2-3 in both genders and could requires vigilant clinical and laboratory follow-up.
PMID: 34625384
ISSN: 2213-2945
CID: 5346582

Benign and Malignant Incidental Findings During Routine Pathology Evaluation of Explanted Livers: Review of 266 Cases in a Single Center [Meeting Abstract]

Li, Ning; Sharma, Kusum; Liu, Yongjun; Zhang, Xiaofei
ISI:000770360203025
ISSN: 0023-6837
CID: 5346872

Frozen Section Evaluation of Donor Liver Biopsies: Agreement between Sub-specialized Liver Pathologists and General Surgical Pathologists [Meeting Abstract]

Sharma, Kusum; Li, Ning; Hu, Rong; Xu, Jin; Zhang, Xiaofei; Liu, Yongjun
ISI:000770360203270
ISSN: 0023-6837
CID: 5346882

Benign and Malignant Incidental Findings During Routine Pathology Evaluation of Explanted Livers: Review of 266 Cases in a Single Center [Meeting Abstract]

Li, Ning; Sharma, Kusum; Liu, Yongjun; Zhang, Xiaofei
ISI:000770361803025
ISSN: 0893-3952
CID: 5346892

Frozen Section Evaluation of Donor Liver Biopsies: Agreement between Sub-specialized Liver Pathologists and General Surgical Pathologists [Meeting Abstract]

Sharma, Kusum; Li, Ning; Hu, Rong; Xu, Jin; Zhang, Xiaofei; Liu, Yongjun
ISI:000770361803270
ISSN: 0893-3952
CID: 5346902

Neoadjuvant Chemotherapy Significantly Alters the Tumor Immune Microenvironment and Stroma Composition in Pancreatic Ductal Adenocarcinoma [Meeting Abstract]

Li, Ning; Yu, Qiqi; Liu, Yongjun; Zhang, Xiaofei
ISI:000770360203110
ISSN: 0023-6837
CID: 5346912

Neoadjuvant Chemotherapy Significantly Alters the Tumor Immune Microenvironment and Stroma Composition in Pancreatic Ductal Adenocarcinoma [Meeting Abstract]

Li, Ning; Yu, Qiqi; Liu, Yongjun; Zhang, Xiaofei
ISI:000770361803110
ISSN: 0893-3952
CID: 5346922