Try a new search

Format these results:

Searched for:

person:delfij02

Total Results:

2


Gender-related differences in the predictive power of exercise stress variables on outcome of myocardial perfusion imaging [Meeting Abstract]

Druz, RS; Delfin, J; Ngai, K
ISI:000232956405133
ISSN: 0009-7322
CID: 2581842

Antithrombotic effect of tissue factor inhibition by inactivated factor VIIa: an ex vivo human study

Lev, Eli I; Marmur, Jonathan D; Zdravkovic, Milan; Osende, Julio I; Robbins, Jonathan; Delfin, Jenny A; Richard, Merwin; Erhardtsen, Elisabeth; Thomsen, Mikael S; Lincoff, A Michael; Badimon, Juan J
FFR-rFVIIa is an inactivated recombinant factor VIIa (rFVIIa) that inhibits the binding of factor VIIa to tissue factor (TF). It has been shown to prevent TF-induced thrombosis in animals. The present study is a substudy of the Active Site Inhibited Seven (ASIS) trial and examines the antithrombotic effect of 3 doses of FFR-rFVIIa in 24 patients undergoing percutaneous coronary intervention (PCI). Group 1 (n=9) received 400 microg/kg FFR-rFVIIa and 40 to 50 U/kg heparin, group 2 (n=7) received 200 microg/kg FFR-rFVIIa and 100 U/kg heparin, and group 3 (n=8) received 50 microg/kg FFR-rFVIIa and 100 U/kg heparin. Blood thrombogenicity was assessed as total thrombus area and fibrin deposition on the perfusion chamber at shear rate conditions typical of mild-moderate coronary stenosis. Baseline blood thrombogenicity was evaluated a day before PCI, after heparin administration. A second perfusion chamber study was performed just before PCI, 15 minutes after the administration of heparin and FFR-rFVIIa. Thrombus formation at a high shear rate was markedly reduced in groups 1 and 2 after drug administration, by 79% to 84% and 76% to 87%, respectively (P<0.004 [group 1], P<0.04 [group 2]). In group 3, moderate thrombus reduction of 46% to 48% was achieved (P<0.04). Fibrin deposition in all 3 groups was nearly eliminated after drug administration. Our data demonstrate that FFR-rFVIIa has a potent antithrombotic effect at different shear rates and severe arterial injury conditions.
PMID: 12067917
ISSN: 1079-5642
CID: 159076