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SDG 10: Placing inequalities in oral health at the core of the global agenda [Editorial]

Benzian, Habib; Raj Mathur, Manu
PMID: 38001177
ISSN: 1476-5373
CID: 5609012

Redefining the non-communicable disease framework to a 6 × 6 approach: incorporating oral diseases and sugars

Benzian, Habib; Daar, Abdallah; Naidoo, Sudeshni
The WHO Global Oral Health Status Report, published in 2022, highlighted the alarming state of oral health worldwide and called for urgent action by integrating oral health into non-communicable diseases (NCDs) and universal health coverage initiatives. 3·5 billion people have oral diseases, surpassing all other NCDs combined. The detrimental role of sugars as a risk factor for oral diseases and other NCDs has also been well documented. Despite the evidence, oral diseases and sugars are not part of the current NCD framing, which focuses on five diseases and five risk factors (ie, 5 × 5). Oral diseases and sugars remain sidelined, disproportionately affecting poor and disadvantaged populations. In this Viewpoint, we advocate for the integration of oral diseases and sugars into the current approach towards the prevention and control of NCDs. An expanded 6 × 6 framework would recognise growing evidence and would reiterate the need to strengthen action, resource allocation, and policy development for NCDs. We present the evidence and rationale for, and benefits of, an expanded NCD framework and detail recommendations to guide efforts towards improved priority, investment, and equitable health outcomes for NCDs, including oral health.
PMID: 37741288
ISSN: 2468-2667
CID: 5591262

The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019

,; Cunha, Amanda Ramos da; Compton, Kelly; Xu, Rixing; Mishra, Rashmi; Drangsholt, Mark Thomas; Antunes, Jose Leopoldo Ferreira; Kerr, Alexander R; Acheson, Alistair R; Lu, Dan; Wallace, Lindsey E; Kocarnik, Jonathan M; Fu, Weijia; Dean, Frances E; Pennini, Alyssa; Henrikson, Hannah Jacqueline; Alam, Tahiya; Ababneh, Emad; Abd-Elsalam, Sherief; Abdoun, Meriem; Abidi, Hassan; Abubaker Ali, Hiwa; Abu-Gharbieh, Eman; Adane, Tigist Demssew; Addo, Isaac Yeboah; Ahmad, Aqeel; Ahmad, Sajjad; Ahmed Rashid, Tarik; Akonde, Maxwell; Al Hamad, Hanadi; Alahdab, Fares; Alimohamadi, Yousef; Alipour, Vahid; Al-Maweri, Sadeq Ali; Alsharif, Ubai; Ansari-Moghaddam, Alireza; Anwar, Sumadi Lukman; Anyasodor, Anayochukwu Edward; Arabloo, Jalal; Aravkin, Aleksandr Y; Aruleba, Raphael Taiwo; Asaad, Malke; Ashraf, Tahira; Athari, Seyyed Shamsadin; Attia, Sameh; Azadnajafabad, Sina; Azangou-Khyavy, Mohammadreza; Badar, Muhammad; Baghcheghi, Nayereh; Banach, Maciej; Bardhan, Mainak; Barqawi, Hiba Jawdat; Bashir, Nasir Z; Bashiri, Azadeh; Benzian, Habib; Bernabe, Eduardo; Bhagat, Devidas S; Bhojaraja, Vijayalakshmi S; Bjørge, Tone; Bouaoud, Souad; Braithwaite, Dejana; Briko, Nikolay Ivanovich; Calina, Daniela; Carreras, Giulia; Chakraborty, Promit Ananyo; Chattu, Vijay Kumar; Chaurasia, Akhilanand; Chen, Meng Xuan; Cho, William C S; Chu, Dinh-Toi; Chukwu, Isaac Sunday; Chung, Eunice; Cruz-Martins, Natália; Dadras, Omid; Dai, Xiaochen; Dandona, Lalit; Dandona, Rakhi; Daneshpajouhnejad, Parnaz; Darvishi Cheshmeh Soltani, Reza; Darwesh, Aso Mohammad; Debela, Sisay Abebe; Derbew Molla, Meseret; Dessalegn, Fikadu Nugusu; Dianati-Nasab, Mostafa; Digesa, Lankamo Ena; Dixit, Shilpi Gupta; Dixit, Abhinav; Djalalinia, Shirin; El Sayed, Iman; El Tantawi, Maha; Enyew, Daniel Berhanie; Erku, Daniel Asfaw; Ezzeddini, Rana; Fagbamigbe, Adeniyi Francis; Falzone, Luca; Fetensa, Getahun; Fukumoto, Takeshi; Gaewkhiew, Piyada; Gallus, Silvano; Gebrehiwot, Mesfin; Ghashghaee, Ahmad; Gill, Paramjit Singh; Golechha, Mahaveer; Goleij, Pouya; Gomez, Ricardo Santiago; Gorini, Giuseppe; Guimaraes, Andre Luiz Sena; Gupta, Bhawna; Gupta, Sapna; Gupta, Veer Bala; Gupta, Vivek Kumar; Haj-Mirzaian, Arvin; Halboub, Esam S; Halwani, Rabih; Hanif, Asif; Hariyani, Ninuk; Harorani, Mehdi; Hasani, Hamidreza; Hassan, Abbas M; Hassanipour, Soheil; Hassen, Mohammed Bheser; Hay, Simon I; Hayat, Khezar; Herrera-Serna, Brenda Yuliana; Holla, Ramesh; Horita, Nobuyuki; Hosseinzadeh, Mehdi; Hussain, Salman; Ilesanmi, Olayinka Stephen; Ilic, Irena M; Ilic, Milena D; Isola, Gaetano; Jaiswal, Abhishek; Jani, Chinmay T; Javaheri, Tahereh; Jayarajah, Umesh; Jayaram, Shubha; Joseph, Nitin; Kadashetti, Vidya; Kandaswamy, Eswar; Karanth, Shama D; Karaye, Ibraheem M; Kauppila, Joonas H; Kaur, Harkiran; Keykhaei, Mohammad; Khader, Yousef Saleh; Khajuria, Himanshu; Khanali, Javad; Khatib, Mahalaqua Nazli; Khayat Kashani, Hamid Reza; Khazeei Tabari, Mohammad Amin; Kim, Min Seo; Kompani, Farzad; Koohestani, Hamid Reza; Kumar, G Anil; Kurmi, Om P; La Vecchia, Carlo; Lal, Dharmesh Kumar; Landires, Iván; Lasrado, Savita; Ledda, Caterina; Lee, Yo Han; Libra, Massimo; Lim, Stephen S; Listl, Stefan; Lopukhov, Platon D; Mafi, Ahmad R; Mahumud, Rashidul Alam; Malik, Ahmad Azam; Mathur, Manu Raj; Maulud, Sazan Qadir; Meena, Jitendra Kumar; Mehrabi Nasab, Entezar; Mestrovic, Tomislav; Mirfakhraie, Reza; Misganaw, Awoke; Misra, Sanjeev; Mithra, Prasanna; Mohammad, Yousef; Mohammadi, Mokhtar; Mohammadi, Esmaeil; Mokdad, Ali H; Moni, Mohammad Ali; Moraga, Paula; Morrison, Shane Douglas; Mozaffari, Hamid Reza; Mubarik, Sumaira; Murray, Christopher J L; Nair, Tapas Sadasivan; Narasimha Swamy, Sreenivas; Narayana, Aparna Ichalangod; Nassereldine, Hasan; Natto, Zuhair S; Nayak, Biswa Prakash; Negru, Serban Mircea; Nggada, Haruna Asura; Nouraei, Hasti; Nuñez-Samudio, Virginia; Oancea, Bogdan; Olagunju, Andrew T; Omar Bali, Ahmed; Padron-Monedero, Alicia; Padubidri, Jagadish Rao; Pandey, Anamika; Pardhan, Shahina; Patel, Jay; Pezzani, Raffaele; Piracha, Zahra Zahid; Rabiee, Navid; Radhakrishnan, Venkatraman; Radhakrishnan, Raghu Anekal; Rahmani, Amir Masoud; Rahmanian, Vahid; Rao, Chythra R; Rao, Sowmya J; Rath, Goura Kishor; Rawaf, David Laith; Rawaf, Salman; Rawassizadeh, Reza; Razeghinia, Mohammad Sadegh; Rezaei, Nazila; Rezaei, Negar; Rezaei, Nima; Rezapour, Aziz; Riad, Abanoub; Roberts, Thomas J; Romero-Rodríguez, Esperanza; Roshandel, Gholamreza; S, Manjula; S N, Chandan; Saddik, Basema; Saeb, Mohammad Reza; Saeed, Umar; Safaei, Mohsen; Sahebazzamani, Maryam; Sahebkar, Amirhossein; Salek Farrokhi, Amir; Samy, Abdallah M; Santric-Milicevic, Milena M; Sathian, Brijesh; Satpathy, Maheswar; Šekerija, Mario; Senthilkumaran, Subramanian; Seylani, Allen; Shafaat, Omid; Shahsavari, Hamid R; Shamsoddin, Erfan; Sharew, Mequannent Melaku; Sharifi-Rad, Javad; Shetty, Jeevan K; Shivakumar, K M; Shobeiri, Parnian; Shorofi, Seyed Afshin; Shrestha, Sunil; Siddappa Malleshappa, Sudeep K; Singh, Paramdeep; Singh, Jasvinder A; Singh, Garima; Sinha, Dhirendra Narain; Solomon, Yonatan; Suleman, Muhammad; Suliankatchi Abdulkader, Rizwan; Taheri Abkenar, Yasaman; Talaat, Iman M; Tan, Ker-Kan; Tbakhi, Abdelghani; Thiyagarajan, Arulmani; Tiyuri, Amir; Tovani-Palone, Marcos Roberto; Unnikrishnan, Bhaskaran; Vo, Bay; Volovat, Simona Ruxandra; Wang, Cong; Westerman, Ronny; Wickramasinghe, Nuwan Darshana; Xiao, Hong; Yu, Chuanhua; Yuce, Deniz; Yunusa, Ismaeel; Zadnik, Vesna; Zare, Iman; Zhang, Zhi-Jiang; Zoladl, Mohammad; Force, Lisa M; Hugo, Fernando N
IMPORTANCE/UNASSIGNED:Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. OBJECTIVE/UNASSIGNED:To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. EVIDENCE REVIEW/UNASSIGNED:The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. FINDINGS/UNASSIGNED:In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. CONCLUSIONS AND RELEVANCE/UNASSIGNED:In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.
PMCID:10485745
PMID: 37676656
ISSN: 2374-2445
CID: 5611702

Global health threats are also oral health threats [Editorial]

Benzian, Habib; Beltrán-Aguilar, Eugenio; Niederman, Richard
PMCID:9951392
PMID: 36841689
ISSN: 1943-4723
CID: 5495502

Effectiveness of school-based strategies to prevent tooth decay in Filipino children: A cluster-randomized trial

Ruff, Ryan Richard; Monse, Bella; Duijster, Denise; Itchon, Gina Santos; Naliponguit, Ella; Benzian, Habib
OBJECTIVES/OBJECTIVE:Evidence for affordable and pragmatic programmes to address the burden of untreated tooth decay in children in low- and middle-income settings is limited. This study aimed to (1) assess the effect of a government-run, school-based daily group toothbrushing programme compared to standard school-based oral health education on the incidence of dental caries and odontogenic infections in Filipino children over a period of 3 years; and (2) assess the additional preventive effect of on-demand oral urgent treatment (OUT) and weekly fluoride gel application. METHODS:A cluster-randomized trial was conducted in Camiguin, Philippines. Schools in three regions were randomly assigned to one of three intervention groups: The Essential Health Care Programme (EHCP), which includes daily toothbrushing with fluoride toothpaste; EHCP plus twice-yearly access to on-demand urgent oral treatment (EHCP + OUT) and EHCP plus weekly application of high-concentrated fluoride gel (EHCP + Fluoride). Schools in a nearby province with a similar child population were selected as external concurrent control group. Clinical oral examinations were performed by calibrated dentists from a random sample of 682 seven-year-old students who were examined at baseline and over the following 3 years. Outcome variables were the number of decayed primary teeth, the number of decayed, missing and filled permanent teeth (DMFT) and surfaces (DMFS), and the number of permanent teeth with pulpal involvement, ulcerations, fistula or abscess (PUFA). Data were analysed using multilevel mixed-effects negative binomial regression. RESULTS:Three years after implementation, increments in dental caries and odontogenic infections in permanent teeth did not significantly differ between the EHCP and control group, yet the incidence of DMFT was lower by 22% in children receiving EHCP. Compared to controls, children receiving EHCP + Fluoride had a significantly lower increment of DMFT, DMFS and PUFA by 40%, 40% and 47%, respectively. Children receiving EHCP + OUT had lower incidence rates of DMFT and DMFS than control children by 23% and 28%, respectively. A lower incidence rate was also found for PUFA, but the effect was not statistically significant. CONCLUSIONS:Findings suggest that the weekly application of fluoride gel and urgent oral treatment, in addition to daily school-based toothbrushing with fluoride toothpaste, are realistic and effective strategies to lower the burden of dental caries in Filipino children. Implementation challenges may explain why no substantial caries-preventive benefits were demonstrated for school-based toothbrushing only. Intervention compliance should be considered in future programme implementation and evaluation research.
PMID: 35112386
ISSN: 1600-0528
CID: 5157162

Universal health coverage cannot be universal without oral health

Winkelmann, Juliane; Listl, Stefan; van Ginneken, Ewout; Vassallo, Paula; Benzian, Habib
PMCID:9810536
PMID: 36516876
ISSN: 2468-2667
CID: 5409222

Oral health in a bold golden frame [Editorial]

Benzian, Habib
PMID: 36707551
ISSN: 1476-5373
CID: 5426642

Redefining the non-communicable disease framework to a 6 x 6 approach: incorporating oral diseases and sugars [Editorial]

Benzian, Habib; Daar, Abdallah; Naidoo, Sudeshni
ISI:001102296800001
ISSN: 2468-2667
CID: 5591212

WHO calls to end the global crisis of oral health

Benzian, Habib; Watt, Richard; Makino, Yuka; Stauf, Nicole; Varenne, Benoit
PMID: 36410360
ISSN: 1474-547x
CID: 5374472

Essential oral health care and universal health coverage go hand in hand [Editorial]

Benzian, Habib; Beltrán-Aguilar, Eugenio; Niederman, Richard
PMID: 36137819
ISSN: 1943-4723
CID: 5439382