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15


Relation of Quantitative Eye Movements with Cognitive Dysfunction in Patients with Concussion [Meeting Abstract]

Gold, Doria; Martone, John; Lee, Yuen Shan Christine; Childs, Amanda; Matsuzawa, Yuka; Fraser, Felicia; Ricker, Joseph; Dai, Wei-Wei; Rizzo, John-Ross; Hudson, Todd; Selesnick, Ivan; Galetta, Steven; Balcer, Laura; Rucker, Janet
ISI:000453090805233
ISSN: 0028-3878
CID: 3561672

Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells

Hillyer, Philippa; Raviv, Nataly; Gold, Doria M; Dougherty, Danielle; Liu, Jie; Johnson, Teresa R; Graham, Barney S; Rabin, Ronald L
Human type I interferons (IFNs) include IFN-β and 12 subtypes of IFN-α. During viral infection, infiltrating memory CD4(+) T cells are exposed to IFNs, but their impact on memory T-cell function is poorly understood. To address this, we pretreated PBMCs with different IFNs for 16 h before stimulation with Staphylococcus aureus enterotoxin B and measured cytokine expression by flow cytometry. IFN-α8 and -α10 most potently enhanced expression of IFN-γ, IL-2, and IL-4. Potency among the subtypes differed most at doses between 10 and 100 U/mL. While enhancement of IL-2 and IL-4 correlated with the time of preincubation with type I IFN, IFN-γ production was enhanced best when IFN-α was added immediately preceding or simultaneously with T-cell stimulation. Comparison of T-cell responses to multiple doses of Staphylococcus aureus enterotoxin B and to peptide libraries from RSV or CMV demonstrated that IFN-α best enhanced cytokine expression when CD4(+) T cells were suboptimally stimulated. We conclude that type I IFNs enhance Th1 and Th2 function with dose dependency and subtype specificity, and best when T-cell stimulation is suboptimal. While type I IFNs may beneficially enhance CD4(+) T-cell memory responses to vaccines or viral pathogens, they may also enhance the function of resident Th2 cells and exacerbate allergic inflammation.
PMID: 24030809
ISSN: 1521-4141
CID: 3214362

Differences in magnitude and timing of human monocyte derived dendritic cell innate immune responses to two strains of respiratory syncytial virus [Meeting Abstract]

Hillyer, Philippa; Chen, Aaron; Schramm, Lynnsie M.; Mane, Viraj P.; Navarro, Maria; Gold, Doria M.; Raviv, Nataly; Rabin, Ronald L.
ISI:000282418400313
ISSN: 1043-4666
CID: 3214392

Differential effects of human interferon-alpha subtypes on CD4 Tcell function [Meeting Abstract]

Gold, Doria M.; Hillyer, Philippa; Raviv, Nataly; Heuer, Melissa A.; Chi, B.; Rabin, Ronald L.
ISI:000282418400252
ISSN: 1043-4666
CID: 3214382

Differential effects of Human Interferon-alpha subtypes on CD4 T cell function [Meeting Abstract]

Gold, Doria; Hillyer, Philippa; Raviv, Nataly; Heuer, Melissa; Chi, Bo; Rabin, Ronald
ISI:000209758303238
ISSN: 0022-1767
CID: 3214372