Evolocumab in Older Individuals: Expanding the Age Horizon [Editorial]
Dhar, Kalyani; Berger, Jeffrey; Newman, Jonathan; Schwartzbard, Arthur; Pernia, Astrid Carolina Jara; Weintraub, Howard S
PMID: 39909682
ISSN: 1558-3597
CID: 5784112
Inference of Germline Mutational Status and Evaluation of Loss of Heterozygosity in High-Depth, Tumor-Only Sequencing Data
Khiabanian, Hossein; Hirshfield, Kim M; Goldfinger, Mendel; Bird, Simon; Stein, Mark; Aisner, Joseph; Toppmeyer, Deborah; Wong, Serena; Chan, Nancy; Dhar, Kalyani; Gheeya, Jinesh; Vig, Hetal; Hadigol, Mohammad; Pavlick, Dean; Ansari, Sepand; Ali, Siraj; Xia, Bing; Rodriguez-Rodriguez, Lorna; Ganesan, Shridar
PURPOSE/OBJECTIVE:, can have significant clinical implications for patient care. METHODS:mutations in 1,636 specimens sequenced at Rutgers Cancer Institute of New Jersey. RESULTS:mutations. CONCLUSION/CONCLUSIONS:LOHGIC can assess LOH status for both germline and somatic mutations. It also can be applied to any gene with candidate, inherited mutations. This approach demonstrates the clinical utility of targeted sequencing in both identifying patients with potential germline alterations in tumor suppressor genes as well as estimating LOH occurrence in cancer cells, which may confer therapeutic relevance.
PMCID:6148761
PMID: 30246169
ISSN: 2473-4284
CID: 5709612