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Blacksburg, Seth; Sheu, Ren-Dih; Demircioglu, Gizem; Mirza, Awais; Carpenter, Todd; Morgenstern, Jason; Witten, Matthew; Mendez, Christopher; Katz, Aaron; Endres, Paul; Oshinsky, Gary; Lumerman, Jeffrey; Shepard, Barry; D\Esposito, Robert; Edelman, Robert; Gershbaum, Meyer David; Nejat, Robert; Haas, Jonathan
ISSN: 0022-5347
CID: 4610332

Grade 2+Bladder Toxicity in Patients Receiving SBRT for Prostate Cancer: Incidence and Dosimetric Characterization in a Large Patient Cohort [Meeting Abstract]

Blacksburg, S. R.; Sheu, R.; Demircioglu, G.; Mirza, A.; Carpenter, T. J.; Morgenstern, J.; Witten, M. R.; Mendez, C.; Katz, A. E.; Endres, P.; Oshinsky, G.; Lumerman, J.; Shepard, B.; D'Esposito, R.; Edelman, R.; Gershbaum, M. D.; Nejat, R.; Haas, J. A.
ISSN: 0360-3016
CID: 3493572

Long-term outcomes after percutaneous renal cryoablation performed with adjunctive techniques

Khan, Faraz; Ho, Andrew M; Jamal, Joseph E; Gershbaum, Meyer D; Katz, Aaron E; Hoffmann, Jason C
OBJECTIVE:To review the technical success of image-guided percutaneous cryoablation of renal masses in difficult anatomic locations using adjunctive techniques to displace critical structures away from the ablation zone, while also reporting longer-term outcomes within this patient population. METHODS:An IRB approved, retrospective analysis of 92 renal masses treated with percutaneous cryoablation revealed 15 cases utilizing adjunctive techniques. Tumor size and distance to adjacent organ before and after adjunctive technique and long-term outcomes were evaluated. RESULTS:The adjunctive techniques used were hydrodissection (n=15) and angioplasty balloon interposition (n=1). Before and after adjunctive technique, median tumor proximity to closest organ was 4mm and 26mm, respectively. All cases had appropriate ablation zones and protection of adjacent critical structures. There is no evidence of recurrence or complication on follow-up (median 51months). CONCLUSIONS:Adjunctive techniques to ablate renal masses in difficult locations provide technical success, safety, and favorable long-term outcomes.
PMID: 29324328
ISSN: 1873-4499
CID: 3002022

Reconstruction of rabbit urethra with surgisis small intestinal submucosa

Rotariu, Paul; Yohannes, Paulos; Alexianu, Mihai; Gershbaum, David; Pinkashov, David; Morgenstern, Nora; Smith, Arthur D
PURPOSE: To evaluate the efficacy of Surgisis, porcine small intestinal submucosa, in the reconstruction of iatrogenic urethral defects in rabbits. MATERIALS AND METHODS: Eight male white rabbits were enrolled in this protocol. A 2.5-cm segment of urethra was excised. One control consisted of a normal urethra. The other rabbits underwent urethroplasty with Surgisis and 6-0 Vicryl running suture. An 8F feeding tube was left in place to divert urine for 2 weeks after surgery. Retrograde urethrograms were performed to assess the patency of the urethras and to rule out fistula formation prior to sacrifice of the animals. The sacrifice protocol began with the control and a urethroplasty animal 6 weeks after surgery. The other rabbits were euthanized at 2-week intervals thereafter. RESULTS: Surgisis promoted epithelial regeneration in all cases. One animal developed a wound infection; this was associated with a small fistula at the proximal end of the anastomosis. Good cosmetic and functional results were documented. Retrograde urethrograms showed no stricture formation at the site of the anastomosis in six rabbits. The histopathologic examination showed complete regeneration of all urethral layers, almost indistinguishable from the normal urethra. CONCLUSION: Surgisis is an excellent material for urethral reconstruction in rabbits. It promotes regeneration of all the components of the host urethral layers and is biodegradable.
PMID: 12470472
ISSN: 0892-7790
CID: 2193532