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Exercise intolerance associated with impaired oxygen extraction in patients with long COVID

Norweg, Anna; Yao, Lanqiu; Barbuto, Scott; Nordvig, Anna S; Tarpey, Thaddeus; Collins, Eileen; Whiteson, Jonathan; Sweeney, Greg; Haas, Francois; Leddy, John
OBJECTIVE:Chronic mental and physical fatigue and post-exertional malaise are the more debilitating symptoms of long COVID-19. The study objective was to explore factors contributing to exercise intolerance in long COVID-19 to guide development of new therapies. Exercise capacity data of patients referred for a cardiopulmonary exercise test (CPET) and included in a COVID-19 Survivorship Registry at one urban health center were retrospectively analyzed. RESULTS:pulse peak % predicted (of 79 ± 12.9) was reduced, supporting impaired energy metabolism as a mechanism of exercise intolerance in long COVID, n = 59. We further identified blunted rise in heart rate peak during maximal CPET. Our preliminary analyses support therapies that optimize bioenergetics and improve oxygen utilization for treating long COVID-19.
PMID: 37076024
ISSN: 1878-1519
CID: 5464512

Mind-Body Intervention for Dysfunctional Breathing in Chronic Obstructive Pulmonary Disease: Feasibility Study and Lessons Learned

Norweg, Anna Migliore; Wu, Yinxiang; Troxel, Andrea; Whiteson, Jonathan H; Collins, Eileen; Haas, Francois; Skamai, Anne; Goldring, Roberta; Jean-Louis, Girardin; Reibman, Joan; Ehrlich-Jones, Linda; Simon, Naomi
PMID: 36800224
ISSN: 2768-3613
CID: 5435382

Acceptability of capnography-assisted respiratory therapy: a new mind-body intervention for COPD

Norweg, Anna Migliore; Skamai, Anne; Kwon, Simona C; Whiteson, Jonathan; MacDonald, Kyle; Haas, Francois; Collins, Eileen G; Goldring, Roberta M; Reibman, Joan; Wu, Yinxiang; Sweeney, Greg; Pierre, Alicia; Troxel, Andrea B; Ehrlich-Jones, Linda; Simon, Naomi M
Dyspnoea self-management is often suboptimal for patients with COPD. Many patients with COPD experience chronic dyspnoea as distressing and disabling, especially during physical activities. Breathing therapy is a behavioural intervention that targets reducing the distress and impact of dyspnoea on exertion in daily living. Using a qualitative design, we conducted interviews with 14 patients after they participated in a novel mind-body breathing therapy intervention adjunct, capnography-assisted respiratory therapy (CART), combined with outpatient pulmonary rehabilitation. Comprehensive CART consisted of patient-centred biofeedback, tailored breathing exercises, a home exercise programme and motivational interviewing counselling. We assessed participants' perceptions and reported experiences to gauge the acceptability of CART and refine CART based on feedback. Constant comparative analysis was used to identify commonalities and themes. We identified three main themes relating to the acceptability and reported benefits of CART: (1) self-regulating breathing; (2) impact on health; and (3) patient satisfaction. Our findings were used to refine and optimise CART (i.e. its intensity, timing and format) for COPD. By addressing dysfunctional breathing behaviours and dysregulated interoception, CART offers a promising new paradigm for relieving dyspnoea and related anxiety in patients with COPD.
PMID: 34938800
ISSN: 2312-0541
CID: 5109002


Sheng, S; Feinberg, J; Bostrom, J; Tang, Y; Sweeney, G; Pierre, A; Katz, E; Whiteson, J; Haas, F; Dodson, J; Halpern, D
Background Cardiac rehabilitation (CR) is increasingly being prescribed for adult congenital heart disease (ACHD) patients after cardiac procedures or for reduced exercise tolerance. We aim to describe the functional capacity improvements of ACHD patients in CR. Methods This retrospective study included ACHD patients at NYU Rusk Cardiac Rehabilitation from 2013-2019. We collected data on patient characteristics, number of sessions attended, and exercise testing results. Paired sample t-tests were used to assess for changes between pre- and post-CR exercise time and metabolic equivalents (METs). Results In total, 76 ACHD patients (mean age 38.2 years, 56.6% female, 89.5% moderate or complex conditions by anatomic classification) participated in CR. Referral indication was reduced exercise tolerance for 43.4% and was post-cardiac procedure (transcatheter or surgical) for the remainder. Among 37 patients (48.7%) who finished all 36 CR sessions, complete exercise testing data was available for 29 of them. Exercise time increased by 83.8 seconds (95% CI, 43.9 - 123.8; baseline mean 520.7), METs increased by 1.2 (95% CI, 0.6 - 1.8; baseline mean 8.1), and both parameters increased for 72.4% of these patients. These statistically significant improvements were observed across referral indications. Conclusion On average, CR benefits ACHD patients who complete the program, regardless of referral indication. Efforts to increase CR referral and retention would allow more patients to benefit. [Formula presented]
ISSN: 0735-1097
CID: 4884642

Effects of Biophilic Nature Imagery on Indexes of Satisfaction in Medically Complex Physical Rehabilitation Patients: An Exploratory Study

Wichrowski, Matthew J; Corchoran, John R; Haas, Francois; Sweeney, Greg; Mcgee, Arlene
OBJECTIVE/UNASSIGNED:Exposure to nature has been shown to influence various dimensions of human experience in the healthcare environment. This mixed method study explores the effects of the presence of biophilic, nature-based imagery on patient perceptions of their hospital room and aspects of their experience in rehabilitation. BACKGROUND/UNASSIGNED:In settings where patients have high degrees of medical acuity and infection control is a major concern, exposure to the benefits of real nature may be precluded. This is also true in many older healthcare facilities which were not designed with salutatory nature exposure in mind. In these settings, the presence of nature imagery may provide benefits which positively impact patient experience. METHOD/UNASSIGNED:Seventy-six physical rehabilitation patients on a medically complex/cardiopulmonary rehabilitation unit filled out questionnaires assessing their perceptions of their room and various indexes of patient satisfaction. Data were collected from 47 patients in enhanced room containing nature imagery and 29 patients in standard rooms which served as controls. RESULTS/UNASSIGNED:= .0071). Ratings of quality of room, quality of stay, quality of sleep, and overall care trended in the direction of the hypothesis but were not significant. Data from qualitative questionnaires supported the results of the EAS. CONCLUSION/UNASSIGNED:We conclude that the presence of biophilic nature imagery in the hospital rooms had a significant effect on patients' room ratings and positively influenced indexes of patient satisfaction.
PMID: 33840230
ISSN: 2167-5112
CID: 4845592

Hippocampal blood flow in normal aging measured with arterial spin labeling at 3T

Rusinek, Henry; Brys, Miroslaw; Glodzik, Lidia; Switalski, Remigiusz; Tsui, Wai-Hon; Haas, Francois; McGorty, Kellyanne; Chen, Qun; de Leon, Mony J
Due to methodological difficulties related to the small size, variable distribution of hippocampal arteries, and the location of the hippocampus in the proximity of middle cranial fossa, little is known about hippocampal blood flow (HBF). We have tested the utility of a pulsed arterial spin labeling sequence based on multi-shot true fast imaging in steady precession to measure HBF in 34 normal volunteers (17 women, 17 men, 26-92 years old). Flow sensitivity to a mild hypercapnic challenge was also examined. Coregistered 3D MPRAGE sequence was used to eliminate from hippocampal and cortical regions of interest all voxel with <75% of gray matter. Large blood vessels were also excluded. HBF in normal volunteers averaged 61.2 +/- 9.0 mL/(100 g min). There was no statistically significant age or gender effect. Under a mild hypercapnia challenge (end tidal CO(2) pressure increase of 6.8 +/- 1.9 mmHg over the baseline), HBF response was 14.1 +/- 10.8 mL/(100 g min), whereas cortical gray matter flow increased by 18.0 +/- 12.2 mL/(100 g min). Flow response among women was significantly larger than in the men. The average absolute difference between two successive HBF measures was 3.6 mL/(100 g min) or 5.4%. The 3T true fast imaging in steady precession arterial spin labeling method offers a HBF measurement strategy that combines good spatial resolution, sensitivity, and minimal image distortions. Magn Reson Med, 2010. (c) 2010 Wiley-Liss, Inc
PMID: 20939094
ISSN: 1522-2594
CID: 116206

Commentaries on Viewpoint: Perception of effort during exercise is independent of afferent feedback from skeletal muscles, heart, and lungs [Comment]

Haas, F
ISSN: 8750-7587
CID: 99302

Regarding "German science and black racism-roots of the Nazi Holocaust" - Response to comments by Ervin G. Erdos [Comment]

Haas, F
ISSN: 0892-6638
CID: 86961

German science and black racism--roots of the Nazi Holocaust

Haas, Francois
The Nazi's cornerstone precept of 'racial hygiene' gave birth to their policy of 'racial cleansing' that led to the murders of millions. It was developed by German physicians and scientists in the late 19th century and is rooted in the period's Social Darwinism that placed blacks at the bottom of the racial ladder. This program was first manifested in the near-extermination of the African Herero people during the German colonial period. After WWI, the fear among the German populace that occupying African troops and their Afro-German children would lead to 'bastardization' of the German people formed a unifying racial principle that the Nazis exploited. They extended this mind-set to a variety of 'unworthy' groups, leading to the physician-administered racial Nuremberg laws, the Sterilization laws, the secret sterilization of Afro-Germans, and the German euthanasia program. This culminated in the extermination camps
PMID: 18239065
ISSN: 1530-6860
CID: 96577

Chronotropic incompetence, beta-blockers, and functional capacity in advanced congestive heart failure: time to pace?

Jorde, Ulrich P; Vittorio, Timothy J; Kasper, Michael E; Arezzi, Emma; Colombo, Paolo C; Goldsmith, Rochelle L; Ahuja, Kartikya; Tseng, Chi-Hong; Haas, Francois; Hirsh, David S
BACKGROUND: Chronotropic incompetence (CI) is often seen in subjects with chronic congestive heart failure (CHF). The prevalence of CI, its mechanisms and association with beta-blocker use as well as exercise capacity have not been clearly defined. METHODS AND RESULTS: Cardiopulmonary exercise tolerance testing data for 278 consecutive patients with systolic CHF was analyzed. CI, defined as the inability to reach 80% of maximally predicted heart rate was present in 128 of 278 subjects (46%). The prevalence of CI was highest in those with most impaired exercise capacity (72, 48, and 24% for subjects with a VO(2) of <14.0, 14.0-20.0, and >20.0 ml/kg/min respectively; p=0.001). While subjects with CI had lower peak exercise heart rate (114 vs. 152 bpm), and lower peak VO(2) (15.4 vs. 19.9 ml/kg/min), they were equally likely to be on chronic beta-blocker therapy (74% vs. 71%; p=0.51). Heart rate and norepinephrine (NE) levels were measured during exercise in a separate cohort of 24 subjects with CHF. There was no difference in beta-blocker dose between subjects with and without CI, however, exercise induced NE release and Chronotropic Responsiveness Index, a measure of post-synaptic beta-receptor sensitivity to NE, were lower in subjects with CI (1687+/-911 vs. 2593+/-1451 pg/ml p=0.08; CRI 12.7+/-5.7 vs. 22.1+/-4.7, p=0.002). CONCLUSIONS: CI occurs in >70% of subjects with advanced systolic CHF irrespective of beta-blocker use and is associated with a trend toward impaired NE release, post-synaptic beta-receptor desensitization and reduced exercise capacity
PMID: 18096432
ISSN: 1388-9842
CID: 96578