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Using a Web-Based Module to Educate Internal Medicine, Neurology Housestaff and Medical Students Regarding the Appropriate Use of Stress Ulcer Prophylaxis: A Randomized Controlled Trial [Meeting Abstract]

Marsicano, Elizabeth V; Joseph, Neal; Clark, John D; Brody, Shara S; Lenchus, Joshua; Isaacson, Richard; Deshpande, Amar R; Sussman, Daniel A
ISSN: 0016-5085
CID: 1716352

The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin

Francois, Fritz; Roper, Jatin; Joseph, Neal; Pei, Zhiheng; Chhada, Aditi; Shak, Joshua R; de Perez, Asalia Z Olivares; Perez-Perez, Guillermo I; Blaser, Martin J
ABSTRACT: BACKGROUND: Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight. METHODS: Veterans referred for upper GI endoscopy were evaluated at baseline and >/=8 weeks after endoscopy, and H. pylori status and body weight were ascertained. During the first visit in all subjects, and during subsequent visits in the initially H. pylori-positive subjects and controls, blood was collected after an overnight fast and 1 h after a standard high protein meal, and levels of eight hormones determined. RESULTS: Of 92 enrolled subjects, 38 were H. pylori-negative, 44 H. pylori-positive, and 10 were indeterminate. Among 23 H. pylori-positive subjects who completed evaluation after treatment, 21 were eradicated, and 2 failed eradication. After a median of seven months following eradication, six hormones related to energy homeostasis showed no significant differences, but post-prandial acylated ghrelin levels were nearly six-fold higher than pre-eradication (p = 0.005), and median integrated leptin levels also increased (20%) significantly (p < 0.001). BMI significantly increased (5 +/- 2%; p = 0.008) over 18 months in the initially H. pylori-positive individuals, but was not significantly changed in those who were H. pylori-negative or indeterminant at baseline. CONCLUSIONS: Circulating meal-associated leptin and ghrelin levels and BMI changed significantly after H. pylori eradication, providing direct evidence that H. pylori colonization is involved in ghrelin and leptin regulation, with consequent effects on body morphometry
PMID: 21489301
ISSN: 1471-230x
CID: 132313

The Use of Appropriate Medical Therapy in an Underserved Population with Inflammatory Bowel Disease (IBD) [Meeting Abstract]

Joseph, Neal; Sussman, Daniel; Clark, John; Deshpande, Amar
ISSN: 0002-9270
CID: 1716342

Plasma Levels of Insulinotropic and Digestive Hormones Predict the Risk of Colonic Adenomas [Meeting Abstract]

Wolff, Martin J; Joseph, Neal; Huie, Maryann L; Quijano, Sergio; Muakkassa, Nora; Martiniuk, Frank; Perez-Perez, Guillermo I; Francois, Fritz
ISSN: 0016-5085
CID: 1716332

The Effect of Acculturation On Colorectal Polyp Prevalence Among Hispanics [Meeting Abstract]

Joseph, Neal; Muakkassa, Nora; Quijano, Sergio; Wolf, Martin J; Francois, Fritz
ISSN: 0016-5107
CID: 1716322