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Biomarkers of Airway Disease, Barrett's and Underdiagnosed Reflux Noninvasively (BAD-BURN): a Case-Control Observational Study Protocol

Javed, Urooj; Podury, Sanjiti; Kwon, Sophia; Liu, Mengling; Kim, Daniel; Zadeh, Aida Fallah; Li, Yiwei; Khan, Abraham; Francois, Fritz; Schwartz, Theresa; Zeig-Owens, Rachel; Grunig, Gabrielle; Veerappan, Arul; Zhou, Joanna; Crowley, George; Prezant, David; Nolan, Anna
BACKGROUND:Particulate matter exposure (PM) is a cause of aerodigestive disease globally. The destruction of the World Trade Center (WTC) exposed first responders and inhabitants of New York City to WTC-PM and caused obstructive airways disease (OAD), gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE). GERD not only diminishes health-related quality of life but also gives rise to complications that extend beyond the scope of BE. GERD can incite or exacerbate allergies, sinusitis, bronchitis, and asthma. Disease features of the aerodigestive axis can overlap, often necessitating more invasive diagnostic testing and treatment modalities. This presents a need to develop novel non-invasive biomarkers of GERD, BE, airway hyperreactivity (AHR), treatment efficacy, and severity of symptoms. METHODS:No GERD or AHR, from the sub-cohort control group. We will then phenotype and examine non-invasive biomarkers of these subgroups to identify under-diagnosis and/or treatment efficacy. The findings may further contribute to the development of future biologically plausible therapies, ultimately enhance patient care and quality of life. DISCUSSION/CONCLUSIONS:Although many studies have suggested interdependence between airway and digestive diseases, the causative factors and specific mechanisms remain unclear. The detection of the disease is further complicated by the invasiveness of conventional GERD diagnosis procedures and the limited availability of disease-specific biomarkers. The management of reflux is important, as it directly increases risk of cancer and negatively impacts quality of life. Therefore, it is vital to develop novel noninvasive disease markers that can effectively phenotype, facilitate early diagnosis of premalignant disease and identify potential therapeutic targets to improve patient care. TRIAL REGISTRATION/BACKGROUND:ClinicalTrials.gov Identifier: NCT05216133; January 18, 2022.
PMCID:11118699
PMID: 38798396
CID: 5651772

SEVERITY OF COVID IS ASSOCIATED WITH AIR POLLUTION: A SINGLE-CENTER ASSESSMENT OF RISK

Kwon, Sophia; Crowley, George; Javed, Urooj; Podury, Sanjiti; Grunig, Gabriele; Nolan, Anna
ORIGINAL:0017074
ISSN: 0012-3692
CID: 5573422

AIRWAY HYPERREACTIVITY INCREASES RISK OF VASCULAR DYSFUNCTION IN WTC-EXPOSED FIREFIGHTERS

Podury, Sanjiti; Javed, Urooj; Kwon, Sophia; Crowley, George; Schwartz, Theresa; Zeig-Owens, Rachel; J. Prezant, David; Nolan, Anna
ORIGINAL:0017076
ISSN: 0012-3692
CID: 5573442

DIET AND THE MICROBIOME IN WTC PARTICULATE MATTER-EXPOSED FIREFIGHTERS WITH LUNG DISEASE: THE FIREHOUSE RANDOMIZED CLINICAL TRIAL

Lam, Rachel; Kim, James; Ramprasad, Mihika; Javed, Urooj; Podury, Sanjiti; Kwon, Sophia; Crowley, George; Schwartz, Theresa; Zeig-Owens, Rachel; J.Prezant, David; Grunig, Gabriele; Nolan, Anna
ORIGINAL:0017077
ISSN: 0012-3692
CID: 5573452

SHORT-ACTING BETA-AGONISTS AND STEROIDS ARE ASSOCIATED WITH THE DEVELOPMENT OF AERODIGESTIVE DISEASE IN PARTICULATE MATTER-EXPOSED FIREFIGHTERS

Javed, Urooj; Podury, Sanjiti; Kwon, Sophia; Crowley, George; Schwartz, Theresa; Zeig-Owens, Rachel; J. Prezant, David; Nolan, Anna
ORIGINAL:0017075
ISSN: 0012-3692
CID: 5573432

Resistin-like Molecule α and Pulmonary Vascular Remodeling: A Multi-Strain Murine Model of Antigen and Urban Ambient Particulate Matter Co-Exposure

Durmus, Nedim; Chen, Wen-Chi; Park, Sung-Hyun; Marsh, Leigh M; Kwon, Sophia; Nolan, Anna; Grunig, Gabriele
Pulmonary hypertension (PH) has a high mortality and few treatment options. Adaptive immune mediators of PH in mice challenged with antigen/particulate matter (antigen/PM) has been the focus of our prior work. We identified key roles of type-2- and type-17 responses in C57BL/6 mice. Here, we focused on type-2-response-related cytokines, specifically resistin-like molecule (RELM)α, a critical mediator of hypoxia-induced PH. Because of strain differences in the immune responses to type 2 stimuli, we compared C57BL/6J and BALB/c mice. A model of intraperitoneal antigen sensitization with subsequent, intranasal challenges with antigen/PM (ovalbumin and urban ambient PM2.5) or saline was used in C57BL/6 and BALB/c wild-type or RELMα-/- mice. Vascular remodeling was assessed with histology; right ventricular (RV) pressure, RV weights and cytokines were quantified. Upon challenge with antigen/PM, both C57BL/6 and BALB/c mice developed pulmonary vascular remodeling; these changes were much more prominent in the C57BL/6 strain. Compared to wild-type mice, RELMα-/- had significantly reduced pulmonary vascular remodeling in BALB/c, but not in C57BL/6 mice. RV weights, RV IL-33 and RV IL-33-receptor were significantly increased in BALB/c wild-type mice, but not in BALB/c-RELMα-/- or in C57BL/6-wild-type or C57BL/6-RELMα-/- mice in response to antigen/PM2.5. RV systolic pressures (RVSP) were higher in BALB/c compared to C57BL/6J mice, and RELMα-/- mice were not different from their respective wild-type controls. The RELMα-/- animals demonstrated significantly decreased expression of RELMβ and RELMγ, which makes these mice comparable to a situation where human RELMβ levels would be significantly modified, as only humans have this single RELM molecule. In BALB/c mice, RELMα was a key contributor to pulmonary vascular remodeling, increase in RV weight and RV cytokine responses induced by exposure to antigen/PM2.5, highlighting the significance of the genetic background for the biological role of RELMα.
PMCID:10418630
PMID: 37569308
ISSN: 1422-0067
CID: 5595412

RELMalpha and Pulmonary Vascular Remodeling: a Multi-Strain Murine Model of Antigen and Urban Ambient PM Co-Exposure

Durmus, Nedim; Chen, Wen Chi; Park, Sung-Hyun; Marsh, Leigh; Kwon, Sophia; Nolan, Anna; Grunig, Gabriele
ORIGINAL:0016943
ISSN: 2310-287x
CID: 5518862

Severe Acute Respiratory Syndrome and Particulate Matter Exposure: A Systematic Review

Podury, Sanjiti; Kwon, Sophia; Javed, Urooj; Farooqi, Muhammad S; Li, Yiwei; Liu, Mengling; Grunig, Gabriele; Nolan, Anna
BACKGROUND:Particulate matter (PM) exposure is responsible for seven million deaths annually and has been implicated in the pathogenesis of respiratory infections such as severe acute respiratory syndrome (SARS). Understanding modifiable risk factors of high mortality, resource burdensome C19 and exposure risks such as PM is key to mitigating their devastating effects. This systematic review focuses on the literature available, identifying the spatial and temporal variation in the role of quantified PM exposure in SARS disease outcome and planning our future experimental studies. METHODS:The systematic review utilized keywords adhered to the PRISMA guidelines. We included original human research studies in English. RESULTS:and SARS-related outcomes. A geographic and temporal variation in both PM and C19's role was observed. CONCLUSION/CONCLUSIONS:C19 is a high mortality and resource intensive disease which devastated the globe. PM exposure is also a global health crisis. Our systematic review focuses on the intersection of this impactful disease-exposure dyad and understanding the role of PM is important in the development of interventions to prevent future spread of viral infections.
PMCID:9962044
PMID: 36836898
ISSN: 2075-1729
CID: 5422392

E-cigarette Whole Body Aerosol Exposure: Acute Cardiovascular Changes and Effects on Subsequent Pneumococcus Infection [Meeting Abstract]

Grunig, G; Ye, C; Voynov, D; Raja, A; Durmus, N; Goriainova, V; Joung, H; Pehlivan, A; Abruzzo, A; Chalupa, D; Kwon, Sophia; Nolan, Anna; Weiser, JN; Elder, ACP; Zelikoff, J
ORIGINAL:0016950
ISSN: 1073-449x
CID: 5519222

Severe Acute Respiratory Syndrome and Particulate Matter Exposure: A Systematic Review [Meeting Abstract]

Podury, S; Kwon, Sophia; Farooqi, MS; Veerappan, A; Li, Y; Liu, M; Grunig, G; Nolan, Anna
ORIGINAL:0016948
ISSN: 1073-449x
CID: 5519202