Try a new search

Format these results:

Searched for:

person:mahajs03

in-biosketch:true

Total Results:

35


Imaging in malignant adrenal cancers

Chapter by: Mahajan, Sonia; Pandit-Taskar, Neeta
in: Nuclear Medicine and Molecular Imaging: Volume 1-4 by
[S.l.] : Elsevier, 2022
pp. 295-310
ISBN: 9780128229606
CID: 5460172

18F-Fluciclovine Uptake in Thymoma Demonstrated on PET/MRI

Tsikitas, Lucas; Karls, Shawn; Kranz, Anca-Oana; Friedman, Kent P; Mahajan, Sonia
A 68-year-old man with a history of prostate cancer post-primary treatment presented with rising prostate-specific antigen levels and was referred for F-fluciclovine PET/MRI to localize recurrent disease. PET/MRI revealed a solitary focus of uptake in a soft tissue nodule in the anterior mediastinum, which was resected and found to be a type B2 thymoma. F-fluciclovine uptake is mediated by amino acid transporters, primarily alanine-serine-cysteine transporter 2 and L-type amino acid transporter 1, previously demonstrated to be expressed on thymic carcinomas. This case highlights the possibility of overexpression of amino acid transporters in thymomas as well, rarely described before.
PMID: 32956127
ISSN: 1536-0229
CID: 4605472

Preserving Radiology Resident Education During the COVID-19 Pandemic: The Simulated Daily Readout

Recht, Michael P; Fefferman, Nancy R; Bittman, Mark E; Dane, Bari; Fritz, Jan; Hoffmann, Jason C; Hood, Joseph; Mercado, Cecilia L; Mahajan, Sonia; Sheth, Monica M
RATIONALE AND OBJECTIVES/OBJECTIVE:The educational value of the daily resident readout, a vital component of resident training, has been markedly diminished due to a significant decrease in imaging volume and case mix diversity. The goal of this study was to create a "simulated" daily readout (SDR) to restore the educational value of the daily readout. MATERIALS AND METHODS/METHODS:To create the SDR the following tasks were performed; selection of cases for a daily worklist for each resident rotation, comprising a combination of normal and abnormal cases; determination of the correct number of cases and the appropriate mix of imaging modalities for each worklist; development of an "educational" environment consisting of separate "instances" of both our Picture Archive Communication System and reporting systems; and the anonymization of all of the cases on the worklists. Surveys of both residents and faculty involved in the SDR were performed to assess its effectiveness. RESULTS:Thirty-two residents participated in the SDR. The daily worklists for the first 20 days of the SDR included 3682 cases. An average of 480 cases per day was dictated by the residents. Surveys of the residents and the faculty involved in the SDR demonstrated that both agreed that the SDR effectively mimics a resident's daily work on rotations and preserves resident education during the Coronavirus Disease 2019 crisis. CONCLUSION/CONCLUSIONS:The development of the SDR provided an effective method of preserving the educational value of the daily readout experience of radiology residents, despite severe decreases in imaging exam volume and case mix diversity during the Coronavirus Disease 2019 pandemic.
PMID: 32553278
ISSN: 1878-4046
CID: 4484992

PET/CT for thyroid disorders

Chapter by: Mahajan, Sonia; Grewal, R
in: Surgical and medical management of diseases of the thyroid and parathyroid by Shaha, Ashok R; Nathan, Cherie-Ann O; Fernandes, Jyotika K; De Souza, Chris; Joshi, Shashank R (Eds)
San Diego, CA : Plural Publishing, [2020]
pp. ?-?
ISBN: 1597568546
CID: 3978342

Clinical value of 18F-FDG-PET/CT in staging cutaneous squamous cell carcinoma

Mahajan, Sonia; Barker, Christopher A; Singh, Bhuvanesh; Pandit-Taskar, Neeta
BACKGROUND:Cutaneous squamous cell carcinoma (cSCC) is the second most common skin malignancy. Computed tomography (CT) and/or MRI are commonly used for staging, however, the role of fluorine-18-fluorodeoxyglucose (F-FDG)-PET is not clearly established. In this study, we evaluated F-FDG-PET/CT imaging for initial staging of cSCC. PATIENTS AND METHODS/METHODS:F-FDG-PET/CT scans performed in patients with newly diagnosed cSCC were reviewed retrospectively. Images were visually assessed for lesions and F-FDG uptake [standardized uptake value (SUV)] in primary and secondary sites was measured. Suspected lesions on F-FDG-PET/CT were correlated with histopathology when available, follow-up imaging or clinical data in others. RESULTS:Twenty-three cSCC patients who underwent F-FDG-PET/CT at diagnosis were evaluated. Primary sites were in head/neck (n=21), chest (n=1), and foot (n=1). All patients had F-FDG-positive scans with a total of 51 F-FDG-positive lesions. All primary lesions (n=24) were F-FDG-positive (SUV: 2.3-22.8; mean 10.2), and additional 27 F-FDG-positive lesions, including 21 nodes, four cutaneous, one osseous and one lung lesion, were noted in 13 patients. Mean size of F-FDG-positive nodes was 0.9 cm (range: 0.4-2.5 cm), predominantly clinically impalpable. Pathology was available for 40/51 lesions; 31 sites positive for malignancy. SUV (mean±SD) was 9.2±6.2 for malignant and 2.7±1.2 for benign lesions. Sensitivity, positive predictive value, and accuracy of F-FDG-PET/CT scan were 100, 77.5, and 77.5%, respectively. F-FDG detected seven additional lesions in three patients, compared to CT/MRI. Overall, staging F-FDG-PET/CT detected nine prior unknown lesions in five patients that were proven metastatic disease by histopathology or follow-up; F-FDG-PET/CT modified management in 5/23 (21.7%) patients. CONCLUSION/CONCLUSIONS:F-FDG-PET/CT has high sensitivity in the detection of cSCC lesions, including small cutaneous and nodal disease, and has a potential role in initial staging and management.
PMID: 31095044
ISSN: 1473-5628
CID: 3971962

Enchondroma of Tibia as Potential False-positive Finding on 68Ga-DOTATOC PET/CT Scan [Case Report]

Mahajan, Sonia; Bodei, Lisa; Huicochea Castellanos, Sandra; Grewal, Ravinder K
A 70-year-old man with a history of carcinoid tumor of small bowel was referred for Ga-DOTATOC study to evaluate the extent of disease. PET/CT scan revealed known metastatic disease in the liver, with other sites of involvement including pancreas, peritoneum, and bones. In addition, moderately intense uptake was noted in proximal right tibia and further correlation on CT showed metaphyseal lesion with "rings and arcs" calcification suggestive of enchondroma. This case highlights the possibility of overexpression of somatostatin receptors in enchondromas, which has been little explored in literature.
PMCID:6289836
PMID: 30371598
ISSN: 1536-0229
CID: 3826482

Integrating Early Rapid Post-Peptide Receptor Radionuclide Therapy Quality Assurance Scan into the Outpatient Setting

Mahajan, Sonia; O'Donoghue, Joseph; Weber, Wolfgang; Bodei, Lisa
Objective/UNASSIGNED:To understand value of early rapid, quality-assurance (QA), post-therapy whole-body scan (Tx-WBS) in patients receiving peptide receptor radionuclide therapy (PRRT) in outpatient setting. Methods/UNASSIGNED:Sixteen patients with metastatic neuroendocrine tumors received PRRT and underwent Tx-WBS after each cycle. Early imaging (3 hour post-injection) was favored. Planar-images obtained on dual-headed gamma camera (speed 30 cm/min) were visually assessed and qualitatively compared with pre-therapy diagnostic scans. Retention% and lesion/spleen (L/S) ratios were calculated. Results/UNASSIGNED:Fifty three Tx-WBS were analyzed. No cutaneous contamination, extravasation or unexpected tracer distribution was observed. 46/53 (87%) Tx-WBS in 14/16 (88%) patients demonstrated uptake in metastatic lesions. No significant correlation was seen between L/S ratios and response on follow-up imaging. Qualitative assessment of follow-up images during four-cycles of PRRT provided preliminary estimate of disease course in 11/16 patients; with unexpected findings in 2. Conclusion/UNASSIGNED:In daily practice, especially in outpatient setting, an early QA post-PRRT scan proved effective for validating successful treatment and allowing preliminary disease monitoring, at no additional cost.
PMCID:6497447
PMID: 31057988
ISSN: 2155-9619
CID: 3971952

Post-treatment 18F-FDG PET/CT surveillance for detection of recurrence in stage III Merkel Cell Carcinoma. [Meeting Abstract]

Mahajan, Sonia; Barker, Christopher; Pandit-Taskar, Neeta
ISI:000473116800502
ISSN: 0161-5505
CID: 3978302

Mazabraud's Syndrome Mimicking Metastases on FDG PET/CT in a Patient With Colon Cancer [Case Report]

Mahajan, Sonia; Goel, Reema; Riedl, Christopher; Ulaner, Gary A
Mazabraud's, a syndrome consisting of fibrous dysplasia and soft tissue myxomas, is a rare disorder with less than 100 cases reported in the literature. Appearance of lesions in Mazabraud's syndrome on FDG PET/CT scan in an oncological scenario can be misinterpreted as malignancy. We present the case of a 69-year-old woman, diagnosed with metastatic colon carcinoma and suspected osseous as well as soft tissue metastases, who was later found to have concomitant Mazabraud's syndrome. This case describes the diagnostic dilemma associated with this unusual entity and importance of differentiating benign and malignant etiologies on FDG PET/CT scan.
PMID: 29863575
ISSN: 1536-0229
CID: 3826472

Ectopic Undescended Parathyroid Adenoma-SPECT/CT Avoids False-Negative Interpretation on 99mTc-MIBI Dual-Phase Scintigraphy [Case Report]

Mahajan, Sonia; Schoder, Heiko
Undescended parathyroid adenomas are rare, and they are easily missed during neck exploration surgery in patients with hyperparathyroidism. Few reports have described ectopic parathyroid adenomas along the carotid arteries at or near the carotid bifurcation. These may be missed on planar Tc-MIBI dual-phase scintigraphy because of overlapping submandibular gland activity. Our case demonstrates the potential advantage of SPECT/CT in parathyroid scintigraphy to overcome this limitation.
PMID: 29293139
ISSN: 1536-0229
CID: 3826462