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Arias-Stella Reaction With Signet Ring-Like Cell Histomorphology

Hernandez, Andrea; Chiaffarano, Jeanine; Mittal, Khushbakhat; Marcus, Alan
Cells with their nucleus pushed to the periphery in a crescent-like fashion by intracytoplasmic vacuole(s) are referred to as signet ring cells when the vacuole(s) contain mucin and signet ring-like cells when they are empty or contain a material other than mucin. Signet ring cells are commonly associated with adenocarcinomas. These cells are uncommon in the endometrium and have been found to be associated with both malignant and benign processes. We report the first case of signet ring-like cells within endometrial glands with Arias-Stella reaction.
PMID: 29172819
ISSN: 1940-2465
CID: 3055392

Ciliated Vulvar Cyst: Case Report of Metaplastic Origin [Meeting Abstract]

Hernandez, Andrea; Chiaffarano, Jeanine; Marcus, Alan
ISI:000422938200253
ISSN: 0002-9173
CID: 3219792

Pelvic Tuberculosis Diagnosed during Operative Laparoscopy for Suspected Ovarian Cancer

Martingano, Daniel; Cagle-Colon, Kayla; Chiaffarano, Jeanine; Marcus, Alan; Contreras, Diana
Background/UNASSIGNED:While the combination of a pelvic mass, very high serum level of CA-125, chest adenopathy, and ascites is concerning for advanced-stage ovarian cancer, the etiology of such a presentation can be due to disseminated pelvic tuberculosis. Case/UNASSIGNED:The patient was diagnosed with disseminated pelvic tuberculosis and multidrug therapy was initiated. Conclusion/UNASSIGNED:Pelvic tuberculosis can mimic advanced-stage ovarian cancer; thus obtaining a tissue sample may be beneficial to more appropriately direct treatment and planning for neoadjuvant therapies given the ineffectiveness of extensive surgical procedures in treating pelvic tuberculosis commonly employed in the treatment of advanced-stage ovarian cancer.
PMCID:5925173
PMID: 29850317
ISSN: 2090-6684
CID: 3136342

Distribution and potential significance of intravillous and intrafibrinous particulate microcalcification

Zeng, Jennifer; Marcus, Alan; Buhtoiarova, Tatiana; Mittal, Khushbakhat
Radiologic studies indicate that placental calcifications seen at 28-32 weeks' gestation are associated with adverse fetal outcome. One type of placental calcification is typically located at the basement membrane of chorionic villi. It has a fine particulate appearance and can only be seen microscopically. We have designated these calcifications as Intravillous and Intrafibrinous Particulate MicroCalcification (IPMC). In this study we examined the distribution and potential significance of IPMC. Placentas from 14 groups of fetal and maternal outcomes are examined histologically for IPMC. These groups were preterm birth, post term birth, intrauterine fetal demise, fetuses with non-reassuring heart rates, intrauterine growth restriction, fetal anomalies, mothers with gestational hypertension, gestational diabetes, placental abruption, pre-eclampsia and placentas of normal spontaneous vaginal births and placentas with chorioamnionitis, chronic villitis and infarcts. We observed fine dust-like particulates deposited in continuous and discrete patches. The particulates were predominantly located in the basement membranes of fibrotic chorionic villi and in perivillous fibrin. Compared to placentas without adverse outcomes, a higher incidence of IPMC was seen in intrauterine fetal demise cases and in cases with infarcts which suggests that hypoxia played a role in the etiology of IPMC.
PMID: 28161068
ISSN: 1532-3102
CID: 2435962

Comparison of Mutational Profiles in Cytology and Corresponding Surgical Specimens from Patients with Lung Adenocarcinoma [Meeting Abstract]

Zia, Hamid; Marcus, Alan; Geraghty, Brian E.; Hoda, Rana S.; Narula, Navneet; Rennert, Hanna; Fernandes, Helen
ISI:000370302503417
ISSN: 0893-3952
CID: 3150742

Comparison of Mutational Profiles in Cytology and Corresponding Surgical Specimens from Patients with Lung Adenocarcinoma [Meeting Abstract]

Zia, Hamid; Marcus, Alan; Geraghty, Brian E.; Hoda, Rana S.; Narula, Navneet; Rennert, Hanna; Fernandes, Helen
ISI:000369270703096
ISSN: 0023-6837
CID: 3151782

Distribution and Potential Significance of Placental Intravillous Particulate Microcalcifications [Meeting Abstract]

Zeng, Jennifer; Marcus, Alan; Buhtoiarova, Tatiana; Mittal, Khushbakhat
ISI:000369270701637
ISSN: 1530-0307
CID: 1955362

Distribution and Potential Significance of Placental Intravillous Particulate Microcalcifications [Meeting Abstract]

Zeng, Jennifer; Marcus, Alan; Buhtoiarova, Tatiana; Mittal, Khushbakhat
ISI:000370302502264
ISSN: 1530-0285
CID: 2019742

Is p16 Staining of CIN II on Cervical Biopsy Predictive of HSIL on Subsequent Cone Biopsy? [Meeting Abstract]

Wang, Zhenglong; Marcus, Alan; Mittal, Khush
ISI:000348948002274
ISSN: 1530-0307
CID: 1486992

Fluorescence microscopy is superior to polarized microscopy for detecting amyloid deposits in Congo red-stained trephine bone marrow biopsy specimens

Marcus, Alan; Sadimin, Evita; Richardson, Maurice; Goodell, Lauri; Fyfe, Billie
The classic gold standard for detecting amyloid deposits is Congo red-stained bright field and polarized microscopy (CRPM). A prior study showed that Congo red fluorescence (CRF) microscopy had increased sensitivity compared with traditional CRPM when analyzing fat pad specimens. The purpose of the current study was to determine the sensitivity of CRF for evaluating Congo red-stained bone marrow biopsy specimens, and to compare these results with those of CRPM. We compared the CRPM and the CRF analyses of 33 trephine bone marrow biopsy specimens with clinical or morphologic suspicion of amyloid deposits. These results were verified against immunohistochemical staining with anti-amyloid P antibody. CRF achieved 100% sensitivity, and CRPM achieved 75% sensitivity. Both groups showed 100% specificity compared with amyloid P immunohistochemical staining. The results show that CRF is a sensitive method to analyze trephine bone marrow biopsy specimens for amyloid deposits.
PMID: 23010714
ISSN: 0002-9173
CID: 1082542