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Methadone Toxicity in a Pediatric Patient: A Case Report [Case Report]

Lumba, Palveen; Medows, Marsha; Lumba, Hitesh; Bray, Leonita
Pediatric morbidity and mortality associated with methadone poisoning have been rising over the years. In this report, we discuss a case of a four-year-old boy who presented with respiratory distress and a depressed level of consciousness. A urine drug testing was performed given the miosis along with the depressed level of consciousness; the test was found to be positive for methadone, and no other cause of drowsiness was identified. This report highlights the importance of urine drug testing in pediatric patients presenting with a depressed level of consciousness.
PMCID:8178017
PMID: 34113498
ISSN: 2168-8184
CID: 4900272

Pancreatitis and Acute Liver Failure From Coricidin® HBP Intoxication [Case Report]

Medows, Marsha; Acosta, Catalina; Vega, Vivian
The use of over-the-counter medications as recreational drugs of abuse in adolescents is increasing. We present the case of a patient who presented with abdominal pain after the ingestion of Coricidin®, an over-the-counter cold medication that contains acetaminophen, chlorpheniramine maleate, and dextromethorphan hydrobromide. The case was complicated by acute liver failure and concomitant pancreatitis that, in a few reported cases, has been associated with high doses of acetaminophen.
PMCID:7532876
PMID: 33033679
ISSN: 2168-8184
CID: 4627222

Critical Event Debriefing in a Community Hospital

Ugwu, Chidiebere V; Medows, Marsha; Don-Pedro, Data; Chan, Joseph
Introduction Medical error is currently the third major cause of death in the United States after cardiac disease and cancer. A significant number of root cause analyses performed revealed that medical errors are mostly attributed to human errors and communication gaps. Debriefing has been identified as a major tool used in identifying medical errors, improving communication, reviewing team performance, and providing emotional support following a critical event. Despite being aware of the importance of debriefing, most healthcare providers fail to make use of this tool on a regular basis, and very few studies have been conducted in regard to the practice of debriefing. This study ascertains the frequency, current practice, and limitations of debriefing following critical events in a community hospital. Design/Methods This was a cross-sectional observational study conducted among attending physicians, physician assistants, residents, and nurses who work in high acuity areas located in the study location. Data on current debriefing practices were obtained and analyzed using descriptive statistics. Results A total of 130 respondents participated in this study. Following a critical event in their department, 65 (50%) respondents reported little (<25% of the time) or no practice of debriefing and only 20 (15.4%) respondents reported frequent practice (>75% of the time). Debriefing was done more than once a week as reported by 35 (26.9%) of the respondents and was led by attending physicians 77 (59.2%). The debrief session sometimes occurred immediately following a critical event (46.9%). Although 118 (90%) of the respondents feel that there is a need to receive some training on debriefing, only 51 (39%) of the respondents have received some form of formal training on the practice of debriefing. Among the healthcare providers who had some form of debriefing in their practice, the few debrief sessions held were to discuss medical management, identify problems with systems/processes, and provide emotional support. Increased workload was identified by 92 (70.8%) respondents as the major limitations to the practice of debriefing. Most respondents support that debriefing should be done immediately after a critical event such as death of a patient (123 [94.6%]), trauma resuscitation (108 [83.1%]), cardiopulmonary arrest (122 [93.8%]), and multiple casualty/disasters (95 [73.1%]). Conclusions In order to reduce medical errors, hospitals and its management team must create an environment that will encourage all patient care workers to have a debriefing session following every critical event. This can be achieved by organizing formal training, creating a template/format for debriefing, and encouraging all hospital units to make this an integral part of their work process.
PMCID:7320638
PMID: 32607306
ISSN: 2168-8184
CID: 4504232

Isolated Chromosome 6q27 Terminal Deletion Syndrome [Case Report]

Bhatta, Sabita; Medows, Marsha; Acharya, Yogesh
Any change in either the short (p) or long (q) arm of chromosome six can result in a variety of disorders.  A two-year-old female child came to us with a history of sudden onset generalized tonic-clonic seizure. She had a syndromic face with frontal bossing and palpable thinning of the right lower lip and an apparent facial asymmetry while crying due to the hypoplasia of the right depressor angularis oris. Her joints were hypermobile and hypotonic. Chromosomal karyotyping exhibited a normal female karyotype, but pathogenic microarray genetic evaluation showed a loss of approximately 783 kb of the 6q27 terminus. She was diagnosed with chromosome 6q27 terminal deletion and managed with anti-seizure medications.  Chromosome 6q27 terminal deletion can present with an array of structural and developmental anomalies. It is, therefore, necessary to understand the typical phenotypic and distinctive clinical features of congenital chromosome 6q27 terminal deletion syndrome for early diagnosis and intervention.
PMCID:7292719
PMID: 32542158
ISSN: 2168-8184
CID: 4484662

Can urinary nitrites or other urinalysis findings be a predictor of bacterial resistance of uncomplicated urinary tract infections?

Medows, Marsha; Nijres, Bassel Mohammad; Elbakoush, Faesal; Alali, Abdulrazak; Patel, Rifali; Mohammad, Sami
Background and objectives/UNASSIGNED:To evaluate whether initial urinalysis (UA) and urinary nitrite results can be used as a proxy for choosing empiric antibiotic therapy. Materials and methods/UNASSIGNED:A retrospective study was conducted in an urban inner city community hospital in New York City (NYU Woodhull Medical Center). We reviewed the charts of patients seen in the Emergency Department and Pediatric Clinic who had a diagnosis of urinary tract infection (UTI) during a 3 year time period (January 2010-December 2012). Statistical analysis was performed using SPSS 20.0 statistical software. Results/UNASSIGNED:, which was detected in 283 (74.9%) isolates. Other bacteria included Klebsiella spp 30 (7.9%), Proteus 21 (5.6%), Enterococcus 14 (3.7%), and others 30 (7.9%). The resistance rate was higher in the nitrite positive group for the following antibiotics: TMP/SMX and ampicillin with or without sulbactam. No significant correlation was found with the remaining studied antibiotics. No significant correlation was found between leukoesterase and the resistance patterns in all of the studied antibiotics, except cefazolin. Conclusion/UNASSIGNED:Urinary nitrite results are not helpful in choosing an initial antibiotic to treat a UTI. Leukocytosis in the blood or urine or the presence of a fever cannot be used to predict bacterial resistance. The use of nitrofurantoin or cephalexin for the treatment of cystitis was optimum, and in the presence of negative leukoesterase, nitrofurantoin was preferable to cephalexin.
PMCID:6372408
PMID: 30805462
ISSN: 2352-6467
CID: 3721782

Delayed subaponeurotic (subgaleal) fluid collection

Medows, Marsha; Mohammad Nijres, Bassel
A 14-week-old boy who is known to have a single right kidney presented to our emergency department with history of fever for 1 day. A sepsis work up was performed (complete blood count, blood culture, urine culture and lumbar puncture) in the emergency room. On the second day of admission he developed swelling in the parieto-occipital area. Head CT showed crescent-shaped extra cranial area of homogeneous low attenuation. He remained asymptomatic with a stable haemoglobin and haematocrit. Swelling subsequently resolved within 5 weeks.
PMCID:4025387
PMID: 24792020
ISSN: 1757-790x
CID: 967722

Fatal Bipolaris spicifera infection in an immunosuppressed child

Teran, Carlos G; Downes, Kevin; Medows, Marsha
PMCID:3918623
PMID: 24493105
ISSN: 1757-790x
CID: 935442

Lancing of a boil leading to severe invasive methicillin-sensitive Staphylococcus aureus infection in an adolescent

Medows, Marsha; Sharma, Amit
A 10-year-old boy presented to the emergency department with chief symptoms of fever and right leg pain for 3 days. Also of note, he reported that he had a boil on his neck 2 weeks prior to admission. This lesion was lanced by his mother with a hot needle. An X-ray, CT scan and MRI of the right knee showed no evidence of osteomyelitis. He was placed on intravenous vancomycin for empiric treatment. Blood culture grew methicillin-susceptible Staphylococcus aureus (MSSA), susceptible to vancomycin and clindamycin. He continued to spike fever with the development of erythema, and swelling of the distal thigh. Repeat MRI of the right knee showed osteomyelitis and subperiosteal abscess in the distal femur shaft with surrounding intramuscular abscesses and pyomyositis. He was taken to the operating room where 50 mL of fluid was drained from the periosteal abscess and a bone biopsy was obtained. Bone marrow culture also grew MSSA, susceptible to clindamycin.
PMCID:3863041
PMID: 24336580
ISSN: 1757-790x
CID: 935432

Herpes zoster ophthalmicus in a healthy child [Case Report]

Teran, Carlos G; Medows, Marsha
PMCID:3669834
PMID: 23697452
ISSN: 1757-790x
CID: 935422

Calf pain: Atypical presentation of acute lymphoblastic leukemia mimicking deep venous thrombosis

Teran, Carlos G; Barillas, Julia; Sunitha, Sura; Medows, Marsha; Varghese, Raymol
PMID: 22631587
ISSN: 1442-200x
CID: 167800