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Education Research: Teaching and assessing communication and professionalism in neurology residency with simulation

Kurzweil, Arielle M; Lewis, Ariane; Pleninger, Perrin; Rostanski, Sara K; Nelson, Aaron; Zhang, Cen; Zabar, Sondra; Ishida, Koto; Balcer, Laura J; Galetta, Steven L
PMID: 31959708
ISSN: 1526-632x
CID: 4272802

Identifying and Addressing Impaired Co-Residents in the Era of Physician Burnout [Meeting Abstract]

Stainman, Rebecca; Lewis, Ariane; Nelson, Aaron; Pleninger, Perrin; Kurzweil, Arielle
ISSN: 0028-3878
CID: 4029402

Zika Virus-Associated Guillain-Barré Syndrome in a Returning US Traveler

Beattie, Jason; Parajuli, Sunita; Sanger, Matthew; Lee, Gregory; Pleninger, Perrin; Crowley, George; Kwon, Sophia; Murthy, Vivek; Manko, Jeffrey A; Caplan, Arthur; Dufort, Elizabeth; Pastula, Daniel M; Nolan, Anna
Zika virus (ZIKV) infection has been associated with Guillain-Barré Syndrome (GBS). Roughly 60% of people in countries such as the U.S. live in areas at risk for seasonal spread of ZIKV. ZIKV belongs to a class of diseases that is not typically seen in hospital settings across the U.S. and Europe. We describe the case presentation, management, and treatment of ZIKV infection complicated by GBS. A 64-year-old woman with recent travel to the Dominican Republic presented with rash followed by an acute, ascending polyneuropathy consistent with GBS. She was confirmed to have an acute ZIKV infection by detection of ZIKV nucleic acid by reverse transcription-polymerase chain reaction. She met Brighton Collaboration criteria level 1 evidence for GBS. She received two courses of intravenous immunoglobulin and slowly improved, though still had weakness at discharge. More research is needed to identify the pathophysiology behind ZIKV-associated GBS and its optimal treatment. Prevention is fundamental to limiting infection and spread of ZIKV.
PMID: 30923438
ISSN: 1056-9103
CID: 3777472

Assessing and Enhancing Neurology Resident Education on Interpersonal Communication and Professionalism [Meeting Abstract]

Kurzweil, Arielle; Lewis, Ariane; Pleninger, Perrin; Rostanski, Sara; Nelson, Aaron; Ishida, Koto; Balcer, Laura; Galetta, Steven
ISSN: 0028-3878
CID: 3561972

A case of cervical radiculopathy due to tuberculosis cervical lymphadenitis

Pellinen, Jacob; Lloyd-Smith, Alexandra; Su, Samantha; Pleninger, Perrin
PMID: 29620071
ISSN: 2163-0402
CID: 3025792

Zika Virus-Associated Guillain-Barre Syndrome In A Returning United States Traveler [Meeting Abstract]

Beattie, J; Parajuli, S; Sanger, M; Lee, G; Pleninger, P; Crowley, G; Kwon, S; Murthy, V; Manko, J; Caplan, A; Dufort, E; Staples, JE; Pastula, D; Nolan, A
ISSN: 1535-4970
CID: 2590942


Tiongson, Vanessa; Kim, Nina; Pleninger, Perrin
ISSN: 1097-4598
CID: 2793732

Neurology Resident Comfort with Ethics and Professionalism [Meeting Abstract]

Trevick, Stephen; Gowda, Ram; Geller, Aaron; Pleninger, Perrin; Lewis, Ariane
ISSN: 1526-632x
CID: 2793742

Botulinum toxin A is effective in treating trismus associated with postradiation myokymia and muscle spasm [Letter]

Lou, J S; Pleninger, P; Kurlan, R
PMID: 8552127
ISSN: 0885-3185
CID: 1664502

Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks

Koy, J F; Pleninger, P; Wall, L; Pramanik, A; Martinez, M; Moore, C W
The recombinogenicity of damaged chromosomes in diploid Saccharomyces cerevisiae cells treated with bleomycin and structurally related phleomycin was measured, along with aneuploidy and mutation events. Phleomycin was substantially (up to 26-fold) more effective than bleomycin in producing genetic changes at all concentrations, even when colony-forming abilities of cells growing in the presence of bleomycin or phleomycin were similar. These results suggest that the DNA lesions produced by the two structurally related analogs could differ in their nature or frequency, or could be processed differently by the cells. Bioassays were developed and used to compare the cytotoxicities of freshly dissolved bleomycin and phleomycin with the cytotoxicities of lysates prepared from bleomycin- and phleomycin-treated cells. Unexpectedly, lysates prepared from bleomycin-treated cells were 1.5-3.5 times more cytotoxic than freshly dissolved bleomycin after 45-min treatments (3-33 x 10(-6) M). In contrast, lysates prepared from phleomycin-treated cells were 3-38 times less cytotoxic than freshly dissolved phleomycin (0.5-6.4 x 10(-6) M). Cytotoxicities of all lysates were higher after 36-h treatments than after 45-min treatments. At 3.3 x 10(-6) M, this increase was eightfold for bleomycin and 15-fold for phleomycin. Nevertheless, lysates from phleomycin-treated cells were considerably more cytotoxic than lysates from bleomycin-treated cells or freshly prepared bleomycin, consistent with the higher effectiveness of phleomycin than bleomycin in producing chromosomal breaks, genetic changes, and cell killing.
PMID: 7528892
ISSN: 0027-5107
CID: 1664512