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16


Intravenous pharmacokinetics and in vitro bactericidal activity of trimethoprim-sulfamethoxazole

Spicehandler J; Pollock AA; Simberkoff MS; Rahal JJ Jr
Trimethoprim-sulfamethoxazole (240 mg of trimethoprim plus 1,200 mg of sulfamethoxazole) was administered intravenously in a volume of 200 ml to 7 volunteers every 12 hr for 4 days. The mean peak levels of TMP and SMZ in plasma were 3.22 and 100 micrograms/ml, respectively, on day 1 and 5.91 and 178 micrograms/ml, respectively, on day 4, when a steady state was achieved. Tests of in vitro susceptibility indicated that these concentrations are bactericidal for a large proportion of enteric gram-negative bacilli
PMID: 6981172
ISSN: 0162-0886
CID: 38211

Netilmicin therapy of gentamicin-sensitive and resistant gram-negative infections

Pollock AA; Stein AJ; Simberkoff MS; Rahal JJ Jr
PMID: 6973928
ISSN: 0002-9629
CID: 38213

Hepatitis associated with high-dose oxacillin therapy

Pollock AA; Berger SA; Simberkoff MS; Rahal JJ Jr
A prospective survey of liver function during oxacillin sodium therapy revealed five cases of drug-related abnormalities among 41 patients. In each instance, the serum transaminase level was increased from normal to greater than 100 units. The serum alkaline phosphatase level was mildly elevated and bilirubin levels remained normal. All of the patients were asymptomatic. Hepatic dysfunction was reversible on withdrawal of oxacillin therapy and substitution of a cephalosporin or clindamycin. The observed abnormalities in liver function were associated with a daily oxacillin sodium dose of greater than or equal to 12 gm as well as with heroin addiction and staphylococcal endocarditis
PMID: 646563
ISSN: 0003-9926
CID: 38225

Isolation of Klebsiella ozaenae and Klebsiella rhinoscleromatis in a general hospital [Case Report]

Berger, S A; Pollock, A A; Richmond, A S
Klebsiella ozaenae and Klebsiella rhinoscleromatis are uncommon organisms usually associated with granulomatous or necrotizing disease of the upper airways. Seven patients are described, non of whom had characteristic clinical manifestations of infection with these species. The organisms were recovered from mixed wound infections or sputum of five patients, and from the blood of three patients. Antibiotic sensitivity patterns were unusual and included susceptibility to both ampicillin and carbenicillin.
PMID: 324264
ISSN: 0002-9173
CID: 157499

Amikacin therapy for serious gram-negative infection

Pollock AA; Berger SA; Richmond AS; Simberkoff MS; Rahal JJ Jr
Amikacin sulfate was administered to 18 patients for the treatment of 19 severe infections. Seventeen infections were caused by gentamicin-resistant Gram-negative bacilli, and 13 patients were bacteremic. Bacteriologic cure was attained in all but one instance, and effective serum, bile, and pleural fluid drug levels were demonstrated. Drug-related fever occurred in one patient, and another experienced a maculopapular rash and monilial intertrigo. In three patients, reversible renal toxicity developed, but none had clinical evidence of ototoxicity. Amikacin sulfate in a dose of 15 mg/kg/day is an effective antibiotic for the treatment of serious Gram-negative infections, particularly those due to gentamicin-resistant organisms
PMID: 576282
ISSN: 0098-7484
CID: 38241

Letter: Neisseria catarrhalis endocarditis [Case Report]

Pollock, A A; Holzman, R S
PMID: 942144
ISSN: 0003-4819
CID: 157500