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39


Dealing with diagnostic bias and uncertainty: What is the burden of proof in toxicology?

Su, Mark K; Brunette, Heather; Frayberg, Marina; Mohan, Sanjay
PMID: 42488957
ISSN: 1556-9519
CID: 6070549

What's new in critical illness and injury science? Pediatric poison prevention - No more "accidents" [Editorial]

Mohan, Sanjay; Perlman, Elise
PMCID:12962442
PMID: 41798048
ISSN: 2229-5151
CID: 6015182

Chloramine/Chlorine Injury Treated with Noninvasive Positive Pressure Ventilation: A Report of Two Cases [Case Report]

Fisher, Richard; Kuschner, Cyrus E; Goldstein, Michael A; Jhaveri, Soha; Mohan, Sanjay; Sud, Payal
INTRODUCTION/BACKGROUND:Chlorine and chloramine gases are pulmonary irritants that can cause pulmonary edema and acute respiratory distress syndrome (ARDS). We present two cases that show effective treatment with noninvasive positive pressure ventilation (NIPPV). CASE REPORTS/METHODS:Case 1. A 9-year-old male developed chloramine pneumonitis and ARDS with hypoxia to 78% on room air after urinating in a bucket of sodium hypochlorite. He was placed on NIPPV with improvement in symptoms and discharged on day four. CASE 2/METHODS:A 58-year-old male developed chlorine gas pneumonitis with hypoxia to 85% on room air. Point-of-care ultrasound of this patient demonstrated greater than three B-lines in bilateral lower lung fields, which resolved after initiating NIPPV. He ultimately left against medical advice. CONCLUSION/CONCLUSIONS:Noninvasive positive pressure ventilation can be an effective treatment modality for severe lung injury secondary to chlorine or chloramine exposure.
PMCID:12594248
PMID: 41191892
ISSN: 2474-252x
CID: 5959812

Demographic and Clinical Characteristics of Pediculosis-associated Severe Anemia in the Emergency Department

Plowe, William; Colling, Reed; Mohan, Sanjay; Gulati, Rajneesh; Biary, Rana; Yanni, Evan; Koziatek, Christian
Introduction: Infestation with Pediculus species, or common lice, is frequently diagnosed in the emergency department (ED). Because lice ingest human blood, prolonged and heavy infestation can plausibly lead to iron deficiency anemia. Severe anemia attributable to lice infestation has infrequently been reported to date. Our objective in this study was to retrospectively review cases of lice-related anemia at a single public hospital to identify risk factors and associated demographic and clinical features of this disease process. Methods: We screened the medical records for patients presenting to the ED of an urban public hospital between 2016–2024 for the diagnoses of lice infestation and severe anemia (hemoglobin < 7 grams per deciliter (g/dL). Cases were reviewed for clinical and demographic characteristics. Results: A total of 932 patients were diagnosed with pediculosis infestation in the ED during the study period; 332 (35.6%) of those patients had a complete blood count obtained by the treating team. Thirty-seven cases of severe anemia were identified (3.9% of total pediculosis cases, 11.1% of those for whom a complete blood count was obtained); 84% were microcytic, indicating iron deficiency anemia. Twenty-five patients (68%) were undomiciled, and nine patients (24%) were shelter domiciled. Twenty-three patients (62%) had comorbid psychiatric diagnoses, and 21 (51%) had substance use disorders. The median hemoglobin was 4.4 g/dL (range 2.4-6.9 g/dL). Thirty patients (81%) were admitted to a medical floor and seven patients (19%) to an intensive care unit, each with a comorbid primary condition. Conclusion: In this cohort, anemia secondary to lice infestation was seen in patients with unstable housing, substance use disorders, and psychiatric disease. Most patients were hemodynamically stable, consistent with the proposed mechanism of chronic blood loss. The prevalence of this condition may be higher than previously noted among this vulnerable population. Emergency physicians should be aware of this rare but potentially serious disease process.
ORIGINAL:0017789
ISSN: 1936-900x
CID: 5954032

Demographic and Clinical Characteristics of Pediculosis-associated Severe Anemia in the Emergency Department

Plowe, William; Colling, Reed; Mohan, Sanjay; Gulati, Rajneesh; Biary, Rana; Yanni, Evan; Koziatek, Christian A
INTRODUCTION/BACKGROUND:Infestation with Pediculus species, or common lice, is frequently diagnosed in the emergency department (ED). Because lice ingest human blood, prolonged and heavy infestation can plausibly lead to iron deficiency anemia. Severe anemia attributable to lice infestation has infrequently been reported to date. Our objective in this study was to retrospectively review cases of lice-related anemia at a single public hospital to identify risk factors and associated demographic and clinical features of this disease process. METHODS:We screened the medical records for patients presenting to the ED of an urban public hospital between 2016-2024 for the diagnoses of lice infestation and severe anemia (hemoglobin < 7 grams per deciliter (g/dL). Cases were reviewed for clinical and demographic characteristics. RESULTS:A total of 932 patients were diagnosed with pediculosis infestation in the ED during the study period; 332 (35.6%) of those patients had a complete blood count obtained by the treating team. Thirty-seven cases of severe anemia were identified (3.9% of total pediculosis cases, 11.1% of those for whom a complete blood count was obtained); 84% were microcytic, indicating iron deficiency anemia. Twenty-five patients (68%) were undomiciled, and nine patients (24%) were shelter domiciled. Twenty-three patients (62%) had comorbid psychiatric diagnoses, and 21 (51%) had substance use disorders. The median hemoglobin was 4.4 g/dL (range 2.4-6.9 g/dL). Thirty patients (81%) were admitted to a medical floor and seven patients (19%) to an intensive care unit, each with a comorbid primary condition. CONCLUSION/CONCLUSIONS:In this cohort, anemia secondary to lice infestation was seen in patients with unstable housing, substance use disorders, and psychiatric disease. Most patients were hemodynamically stable, consistent with the proposed mechanism of chronic blood loss. The prevalence of this condition may be higher than previously noted among this vulnerable population. Emergency physicians should be aware of this rare but potentially serious disease process.
PMCID:12698163
PMID: 41380074
ISSN: 1936-9018
CID: 5977802

Chloramine/Chlorine Injury Treated with Noninvasive Positive Pressure Ventilation: A Report of Two Cases

Fisher, Richard; Kuschner, Cyrus; Goldstein, Michael; Jhaveri, Soha; Mohan, Sanjay; Sud, Payal
ORIGINAL:0017788
ISSN: 2474-252x
CID: 5953102

Biostatistics and Epidemiology for the Toxicologist: Miscellaneous Bias - Confirmation, Non-Response, Survivorship, and Selection

Ortego, Alexandra; Mohan, Sanjay; Su, Mark K
PMID: 40531389
ISSN: 1937-6995
CID: 5870582

Biostatistics and Epidemiology for the Toxicologist: Types of Information Bias (Part II)

Mohan, Sanjay; Perlman, Elise; Su, Mark K
PMID: 40064843
ISSN: 1937-6995
CID: 5808272

Persistent Odynophagia 27 Days After Emergent Intubation

White, Richard; Mander, Kaitlyn; Koziatek, Christian A; Mohan, Sanjay
CASE PRESENTATION/METHODS:We describe a case of persistent odynophagia due to a retained foreign body 27 days after emergent intubation. DISCUSSION/CONCLUSIONS:Dentures constitute a potential esophageal foreign body and warrant special consideration during airway management. Odynophagia, dysphagia, and changes in phonation should prompt consideration of retained esophageal foreign bodies, especially in the post-intubation setting.
PMID: 39903625
ISSN: 2474-252x
CID: 5783872

Biostatistics and Epidemiology for the Toxicologist: Information Bias-Differential and Non-Differential Misclassification (Part I)

Perlman, Elise; Mohan, Sanjay; Su, Mark K
PMID: 39612149
ISSN: 1937-6995
CID: 5761112